Pesquisa | BVS IEC

1.

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.

Grosch, Melanie; Brunner, Katrin; Ilyaskin, Alexandr V; Schober, Michael; Staudner, Tobias; Schmied, Denise; Stumpp, Tina; Schmidt, Kerstin N; Madej, M Gregor; Pessoa, Thaissa D; Othmen, Helga; Kubitza, Marion; Osten, Larissa; de Vries, Uwe; Mair, Magdalena M; Somlo, Stefan; Moser, Markus; Kunzelmann, Karl; Ziegler, Christine; Haerteis, Silke; Korbmacher, Christoph; Witzgall, Ralph.

J Cell Sci ; 134(16)2021 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-34345895

2.

A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness.

Issler, Naomi; Afonso, Sara; Weissman, Irith; Jordan, Katrin; Cebrian-Serrano, Alberto; Meindl, Katrin; Dahlke, Eileen; Tziridis, Konstantin; Yan, Guanhua; Robles-López, José M; Tabernero, Lydia; Patel, Vaksha; Kesselheim, Anne; Klootwijk, Enriko D; Stanescu, Horia C; Dumitriu, Simona; Iancu, Daniela; Tekman, Mehmet; Mozere, Monika; Jaureguiberry, Graciana; Outtandy, Priya; Russell, Claire; Forst, Anna-Lena; Sterner, Christina; Heinl, Elena-Sofia; Othmen, Helga; Tegtmeier, Ines; Reichold, Markus; Schiessl, Ina Maria; Limm, Katharina; Oefner, Peter; Witzgall, Ralph; Fu, Lifei; Theilig, Franziska; Schilling, Achim; Shuster Biton, Efrat; Kalfon, Limor; Fedida, Ayalla; Arnon-Sheleg, Elite; Ben Izhak, Ofer; Magen, Daniella; Anikster, Yair; Schulze, Holger; Ziegler, Christine; Lowe, Martin; Davies, Benjamin; Böckenhauer, Detlef; Kleta, Robert; Falik Zaccai, Tzipora C; Warth, Richard.

J Am Soc Nephrol ; 33(4): 732-745, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35149593

3.

Golgi bypass of ciliary proteins.

Witzgall, Ralph.

Semin Cell Dev Biol ; 83: 51-58, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-29559335

4.

Dual-axis STEM tomography at 200 kV: Setup, performance, limitations.

Rachel, Reinhard; Walther, Paul; Maaßen, Christine; Daberkow, Ingo; Matsuoka, Masahiro; Witzgall, Ralph.

J Struct Biol ; 211(3): 107551, 2020 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-32589927

5.

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.

Ciolek, Justyna; Reinfrank, Helen; Quinton, Loïc; Viengchareun, Say; Stura, Enrico A; Vera, Laura; Sigismeau, Sabrina; Mouillac, Bernard; Orcel, Hélène; Peigneur, Steve; Tytgat, Jan; Droctové, Laura; Beau, Fabrice; Nevoux, Jerome; Lombès, Marc; Mourier, Gilles; De Pauw, Edwin; Servent, Denis; Mendre, Christiane; Witzgall, Ralph; Gilles, Nicolas.

Proc Natl Acad Sci U S A ; 114(27): 7154-7159, 2017 07 03.

Artigo em Inglês | MEDLINE | ID: mdl-28630289

6.

Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure.

Reichold, Markus; Klootwijk, Enriko D; Reinders, Joerg; Otto, Edgar A; Milani, Mario; Broeker, Carsten; Laing, Chris; Wiesner, Julia; Devi, Sulochana; Zhou, Weibin; Schmitt, Roland; Tegtmeier, Ines; Sterner, Christina; Doellerer, Hannes; Renner, Kathrin; Oefner, Peter J; Dettmer, Katja; Simbuerger, Johann M; Witzgall, Ralph; Stanescu, Horia C; Dumitriu, Simona; Iancu, Daniela; Patel, Vaksha; Mozere, Monika; Tekman, Mehmet; Jaureguiberry, Graciana; Issler, Naomi; Kesselheim, Anne; Walsh, Stephen B; Gale, Daniel P; Howie, Alexander J; Martins, Joana R; Hall, Andrew M; Kasgharian, Michael; O'Brien, Kevin; Ferreira, Carlos R; Atwal, Paldeep S; Jain, Mahim; Hammers, Alexander; Charles-Edwards, Geoffrey; Choe, Chi-Un; Isbrandt, Dirk; Cebrian-Serrano, Alberto; Davies, Ben; Sandford, Richard N; Pugh, Christopher; Konecki, David S; Povey, Sue; Bockenhauer, Detlef; Lichter-Konecki, Uta.

J Am Soc Nephrol ; 29(7): 1849-1858, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29654216

7.

Electron microscopy of Drosophila garland cell nephrocytes: Optimal preparation, immunostaining and STEM tomography.

Hochapfel, Florian; Denk, Lucia; Maaßen, Christine; Zaytseva, Yulia; Rachel, Reinhard; Witzgall, Ralph; Krahn, Michael P.

J Cell Biochem ; 119(10): 8011-8021, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-29380411

8.

Casein kinase 1Îµ and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

Billot, Katy; Coquil, Charlène; Villiers, Benoit; Josselin-Foll, Béatrice; Desban, Nathalie; Delehouzé, Claire; Oumata, Nassima; Le Meur, Yannick; Boletta, Alessandra; Weimbs, Thomas; Grosch, Melanie; Witzgall, Ralph; Saunier, Sophie; Fischer, Evelyne; Pontoglio, Marco; Fautrel, Alain; Mrug, Michal; Wallace, Darren; Tran, Pamela V; Trudel, Marie; Bukanov, Nikolay; Ibraghimov-Beskrovnaya, Oxana; Meijer, Laurent.

Am J Physiol Renal Physiol ; 315(1): F57-F73, 2018 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-29537311

9.

Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes.

Hochapfel, Florian; Denk, Lucia; Mendl, Gudrun; Schulze, Ulf; Maaßen, Christine; Zaytseva, Yulia; Pavenstädt, Hermann; Weide, Thomas; Rachel, Reinhard; Witzgall, Ralph; Krahn, Michael P.

Cell Mol Life Sci ; 74(24): 4573-4586, 2017 12.

Artigo em Inglês | MEDLINE | ID: mdl-28717874

10.

Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function.

Staffel, Janina; Valletta, Daniela; Federlein, Anna; Ehm, Katharina; Volkmann, Regine; Füchsl, Andrea M; Witzgall, Ralph; Kuhn, Michaela; Schweda, Frank.

J Am Soc Nephrol ; 28(1): 260-277, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-27153922

11.

Nail-patella syndrome.

Witzgall, Ralph.

Pflugers Arch ; 469(7-8): 927-936, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28681095

12.

Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome.

Klootwijk, Enriko D; Reichold, Markus; Helip-Wooley, Amanda; Tolaymat, Asad; Broeker, Carsten; Robinette, Steven L; Reinders, Joerg; Peindl, Dominika; Renner, Kathrin; Eberhart, Karin; Assmann, Nadine; Oefner, Peter J; Dettmer, Katja; Sterner, Christina; Schroeder, Josef; Zorger, Niels; Witzgall, Ralph; Reinhold, Stephan W; Stanescu, Horia C; Bockenhauer, Detlef; Jaureguiberry, Graciana; Courtneidge, Holly; Hall, Andrew M; Wijeyesekera, Anisha D; Holmes, Elaine; Nicholson, Jeremy K; O'Brien, Kevin; Bernardini, Isa; Krasnewich, Donna M; Arcos-Burgos, Mauricio; Izumi, Yuichiro; Nonoguchi, Hiroshi; Jia, Yuzhi; Reddy, Janardan K; Ilyas, Mohammad; Unwin, Robert J; Gahl, William A; Warth, Richard; Kleta, Robert.

N Engl J Med ; 370(2): 129-38, 2014 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-24401050

13.

Intravital Imaging Reveals Angiotensin II-Induced Transcytosis of Albumin by Podocytes.

Schießl, Ina Maria; Hammer, Anna; Kattler, Veronika; Gess, Bernhard; Theilig, Franziska; Witzgall, Ralph; Castrop, Hayo.

J Am Soc Nephrol ; 27(3): 731-44, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26116357

14.

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance.

Dong, Lihua; Pietsch, Stefan; Tan, Zenglai; Perner, Birgit; Sierig, Ralph; Kruspe, Dagmar; Groth, Marco; Witzgall, Ralph; Gröne, Hermann-Josef; Platzer, Matthias; Englert, Christoph.

J Am Soc Nephrol ; 26(9): 2118-28, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-25556170

15.

Advanced electron microscopic techniques provide a deeper insight into the peculiar features of podocytes.

Burghardt, Tillmann; Hochapfel, Florian; Salecker, Benjamin; Meese, Christine; Gröne, Hermann-Josef; Rachel, Reinhard; Wanner, Gerhard; Krahn, Michael P; Witzgall, Ralph.

Am J Physiol Renal Physiol ; 309(12): F1082-9, 2015 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-26400546

16.

The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function.

Faria, Diana; Rock, Jason R; Romao, Ana M; Schweda, Frank; Bandulik, Sascha; Witzgall, Ralph; Schlatter, Eberhard; Heitzmann, Dirk; Pavenstädt, Hermann; Herrmann, Edwin; Kunzelmann, Karl; Schreiber, Rainer.

Kidney Int ; 85(6): 1369-81, 2014 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24476694

17.

LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys.

Burghardt, Tillmann; Kastner, Jürgen; Suleiman, Hani; Rivera-Milla, Eric; Stepanova, Natalya; Lottaz, Claudio; Kubitza, Marion; Böger, Carsten A; Schmidt, Sarah; Gorski, Mathias; de Vries, Uwe; Schmidt, Helga; Hertting, Irmgard; Kopp, Jeffrey; Rascle, Anne; Moser, Markus; Heid, Iris M; Warth, Richard; Spang, Rainer; Wegener, Joachim; Mierke, Claudia T; Englert, Christoph; Witzgall, Ralph.

J Am Soc Nephrol ; 24(11): 1830-48, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23990680

18.

Phosphorylation of C-terminal polycystin-2 influences the interaction with PIGEA14: a QCM study based on solid supported membranes.

Morick, Daniela; Schatz, Michaela; Hubrich, Raphael; Hoffmeister, Helen; Krefft, Anya; Witzgall, Ralph; Steinem, Claudia.

Biochem Biophys Res Commun ; 437(4): 532-7, 2013 Aug 09.

Artigo em Inglês | MEDLINE | ID: mdl-23838289

19.

KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.

Reichold, Markus; Zdebik, Anselm A; Lieberer, Evelyn; Rapedius, Markus; Schmidt, Katharina; Bandulik, Sascha; Sterner, Christina; Tegtmeier, Ines; Penton, David; Baukrowitz, Thomas; Hulton, Sally-Anne; Witzgall, Ralph; Ben-Zeev, Bruria; Howie, Alexander J; Kleta, Robert; Bockenhauer, Detlef; Warth, Richard.

Proc Natl Acad Sci U S A ; 107(32): 14490-5, 2010 Aug 10.

Artigo em Inglês | MEDLINE | ID: mdl-20651251

20.

Impact of interferon-Î³ on the target cell tropism of nanoparticles.

Zimmer, Oliver; Walter, Melanie; Remmert, Marius; Maier, Olga; Witzgall, Ralph; Goepferich, Achim.

J Control Release ; 362: 325-341, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37598888

BVS IEC

Instituto Evandro Chagas

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