1.
Chem Commun (Camb)
; 59(29): 4328-4331, 2023 Apr 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36942986
RESUMO
We report the synthesis of hydroxyl-radical (ËOH) responsive fluorescent probes that utilise the 3,5-dihydroxybenzyl (DHB) functionality. 4-Methylumbeliferone-DHB (Umb-DHB) and resorufin-DHB (Res-DHB) in the presence of ËOH radicals resulted in significant increases in their respective fluorescent emission intensities at 460 nm and 585 nm. The incubation of Res-DHB in HeLa cells followed by therapeutic ultrasound (1 MHz) resulted in a significant increase in fluorescence emission intensity thus permitting the ability to monitor ultrasound-induced ËOH production in live cells.