Pesquisa | BVS IEC

1.

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.

Fu, Jianing; Wu, Hao.

Annu Rev Immunol ; 41: 301-316, 2023 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-36750315

2.

NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.

David, Liron; Borges, Jazlyn P; Hollingsworth, L Robert; Volchuk, Allen; Jansen, Isabelle; Garlick, Evelyn; Steinberg, Benjamin E; Wu, Hao.

Cell ; 187(9): 2224-2235.e16, 2024 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-38614101

3.

Ex utero monkey embryogenesis from blastocyst to early organogenesis.

Gong, Yandong; Bai, Bing; Sun, Nianqin; Ci, Baiquan; Shao, Honglian; Zhang, Ting; Yao, Hui; Zhang, Youyue; Niu, Yuyu; Liu, Lizhong; Zhao, Hu; Wu, Hao; Zhang, Lei; Wang, Tianxiang; Li, Shangang; Wei, Yulei; Yu, Yang; Ribeiro Orsi, Ana Elisa; Liu, Bing; Ji, Weizhi; Wu, Jun; Chen, Yongchang; Tan, Tao.

Cell ; 186(10): 2092-2110.e23, 2023 05 11.

Artigo em Inglês | MEDLINE | ID: mdl-37172563

4.

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome.

Malachowski, Thomas; Chandradoss, Keerthivasan Raanin; Boya, Ravi; Zhou, Linda; Cook, Ashley L; Su, Chuanbin; Pham, Kenneth; Haws, Spencer A; Kim, Ji Hun; Ryu, Han-Seul; Ge, Chunmin; Luppino, Jennifer M; Nguyen, Son C; Titus, Katelyn R; Gong, Wanfeng; Wallace, Owen; Joyce, Eric F; Wu, Hao; Rojas, Luis Alejandro; Phillips-Cremins, Jennifer E.

Cell ; 186(26): 5840-5858.e36, 2023 12 21.

Artigo em Inglês | MEDLINE | ID: mdl-38134876

5.

Structural biology of innate immunity.

Yin, Qian; Fu, Tian-Min; Li, Jixi; Wu, Hao.

Annu Rev Immunol ; 33: 393-416, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25622194

6.

Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors.

Xiong, Xiaozhe; Tian, Songhai; Yang, Pan; Lebreton, Francois; Bao, Huan; Sheng, Kuanwei; Yin, Linxiang; Chen, Pengsheng; Zhang, Jie; Qi, Wanshu; Ruan, Jianbin; Wu, Hao; Chen, Hong; Breault, David T; Wu, Hao; Earl, Ashlee M; Gilmore, Michael S; Abraham, Jonathan; Dong, Min.

Cell ; 185(7): 1157-1171.e22, 2022 03 31.

Artigo em Inglês | MEDLINE | ID: mdl-35259335

7.

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.

Andreeva, Liudmila; David, Liron; Rawson, Shaun; Shen, Chen; Pasricha, Teerithveen; Pelegrin, Pablo; Wu, Hao.

Cell ; 184(26): 6299-6312.e22, 2021 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-34861190

8.

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.

Shen, Chen; Li, Runzhi; Negro, Roberto; Cheng, Jiewei; Vora, Setu M; Fu, Tian-Min; Wang, Anmin; He, Kaixin; Andreeva, Liudmila; Gao, Pu; Tian, Zhigang; Flavell, Richard A; Zhu, Shu; Wu, Hao.

Cell ; 184(23): 5759-5774.e20, 2021 11 11.

Artigo em Inglês | MEDLINE | ID: mdl-34678144

9.

All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1.

Fan, Linlin Z; Kheifets, Simon; Böhm, Urs L; Wu, Hao; Piatkevich, Kiryl D; Xie, Michael E; Parot, Vicente; Ha, Yooree; Evans, Kathryn E; Boyden, Edward S; Takesian, Anne E; Cohen, Adam E.

Cell ; 180(3): 521-535.e18, 2020 02 06.

Artigo em Inglês | MEDLINE | ID: mdl-31978320

10.

Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.

Pan, Liqiang; Fu, Tian-Min; Zhao, Wenbin; Zhao, Linlin; Chen, Wen; Qiu, Chixiao; Liu, Wenhui; Liu, Zhijun; Piai, Alessandro; Fu, Qingshan; Chen, Shuqing; Wu, Hao; Chou, James J.

Cell ; 176(6): 1477-1489.e14, 2019 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-30827683

11.

The Making of a Flight Feather: Bio-architectural Principles and Adaptation.

Chang, Wei-Ling; Wu, Hao; Chiu, Yu-Kun; Wang, Shuo; Jiang, Ting-Xin; Luo, Zhong-Lai; Lin, Yen-Cheng; Li, Ang; Hsu, Jui-Ting; Huang, Heng-Li; Gu, How-Jen; Lin, Tse-Yu; Yang, Shun-Min; Lee, Tsung-Tse; Lai, Yung-Chi; Lei, Mingxing; Shie, Ming-You; Yao, Cheng-Te; Chen, Yi-Wen; Tsai, J C; Shieh, Shyh-Jou; Hwu, Yeu-Kuang; Cheng, Hsu-Chen; Tang, Pin-Chi; Hung, Shih-Chieh; Chen, Chih-Feng; Habib, Michael; Widelitz, Randall B; Wu, Ping; Juan, Wen-Tau; Chuong, Cheng-Ming.

Cell ; 179(6): 1409-1423.e17, 2019 11 27.

Artigo em Inglês | MEDLINE | ID: mdl-31778655

12.

Structural transitions enable interleukin-18 maturation and signaling.

Dong, Ying; Bonin, Jeffrey P; Devant, Pascal; Liang, Zhuoyi; Sever, Alexander I M; Mintseris, Julian; Aramini, James M; Du, Gang; Gygi, Stephen P; Kagan, Jonathan C; Kay, Lewis E; Wu, Hao.

Immunity ; 2024 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-38733997

13.

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.

Mompeán, Miguel; Li, Wenbo; Li, Jixi; Laage, Ségolène; Siemer, Ansgar B; Bozkurt, Gunes; Wu, Hao; McDermott, Ann E.

Cell ; 173(5): 1244-1253.e10, 2018 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-29681455

14.

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.

Liu, X Shawn; Wu, Hao; Krzisch, Marine; Wu, Xuebing; Graef, John; Muffat, Julien; Hnisz, Denes; Li, Charles H; Yuan, Bingbing; Xu, Chuanyun; Li, Yun; Vershkov, Dan; Cacace, Angela; Young, Richard A; Jaenisch, Rudolf.

Cell ; 172(5): 979-992.e6, 2018 02 22.

Artigo em Inglês | MEDLINE | ID: mdl-29456084

15.

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1.

Koh, Ara; Molinaro, Antonio; Ståhlman, Marcus; Khan, Muhammad Tanweer; Schmidt, Caroline; Mannerås-Holm, Louise; Wu, Hao; Carreras, Alba; Jeong, Heeyoon; Olofsson, Louise E; Bergh, Per-Olof; Gerdes, Victor; Hartstra, Annick; de Brauw, Maurits; Perkins, Rosie; Nieuwdorp, Max; Bergström, Göran; Bäckhed, Fredrik.

Cell ; 175(4): 947-961.e17, 2018 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-30401435

16.

BATF3 programs CD8⁺ T cell memory.

Ataide, Marco A; Komander, Karl; Knöpper, Konrad; Peters, Annika E; Wu, Hao; Eickhoff, Sarah; Gogishvili, Tea; Weber, Justus; Grafen, Anika; Kallies, Axel; Garbi, Natalio; Einsele, Hermann; Hudecek, Michael; Gasteiger, Georg; Hölzel, Michael; Vaeth, Martin; Kastenmüller, Wolfgang.

Nat Immunol ; 21(11): 1397-1407, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32989328

17.

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.

Hu, Jun Jacob; Liu, Xing; Xia, Shiyu; Zhang, Zhibin; Zhang, Ying; Zhao, Jingxia; Ruan, Jianbin; Luo, Xuemei; Lou, Xiwen; Bai, Yang; Wang, Junhong; Hollingsworth, L Robert; Magupalli, Venkat Giri; Zhao, Li; Luo, Hongbo R; Kim, Justin; Lieberman, Judy; Wu, Hao.

Nat Immunol ; 21(7): 736-745, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32367036

18.

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.

Miao, Rui; Jiang, Cong; Chang, Winston Y; Zhang, Haiwei; An, Jinsu; Ho, Felicia; Chen, Pengcheng; Zhang, Han; Junqueira, Caroline; Amgalan, Dulguun; Liang, Felix G; Zhang, Junbing; Evavold, Charles L; Hafner-Bratkovic, Iva; Zhang, Zhibin; Fontana, Pietro; Xia, Shiyu; Waldeck-Weiermair, Markus; Pan, Youdong; Michel, Thomas; Bar-Peled, Liron; Wu, Hao; Kagan, Jonathan C; Kitsis, Richard N; Zhang, Peng; Liu, Xing; Lieberman, Judy.

Immunity ; 56(11): 2523-2541.e8, 2023 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-37924812

19.

SERPINB1-mediated checkpoint of inflammatory caspase activation.

Choi, Youn Jung; Kim, Stephanie; Choi, Younho; Nielsen, Travis B; Yan, Jun; Lu, Alvin; Ruan, Jianbin; Lee, Hye-Ra; Wu, Hao; Spellberg, Brad; Jung, Jae U.

Nat Immunol ; 20(3): 276-287, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30692621

20.

Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation.