A New Species of the Blind Cave Loach Genus Protocobitis (Cypriniformes: Cobitidae), Protocobitis longicostatus sp. nov., from Guangxi, China.

Protocobitis species are typical cave-dwelling fish, exhibiting distinctive morphological adaptations such as colorless body, lack of eyes, and reduced scales and ribs in response to their extreme cave habitats. Distinct from the recorded species, P. anteroventris, P. polylepis, and P. typhlops, a new species, Protocobitis longicostatus sp. nov., is described from Guangxi Zhuang Autonomous Region, China. Protocobitis longicostatus sp. nov. can easily be distinguished from all known congeners by the following characteristics: whole body covered by scales except head, 12 branched caudal fin rays, and long ribs. These species face threats from habitat degradation, hydrological changes, and environmental pollution. Thus, the conservation of cavefish in China has become an urgent issue.

Pooled analysis of the oncological outcomes in robotic gastrectomy versus laparoscopic gastrectomy for gastric cancer.

AIM: Robotic gastrectomy (RG) is more and more widely used in the treatment of gastric cancer. However, the long-term oncological outcomes of RG have not been well evaluated. The aim of this study was to evaluate the long-term oncological outcomes of RG and laparoscopic gastrectomy (LG) in the treatment of gastric cancer. MATERIALS AND METHODS: PubMed, China National Knowledge Infrastructure, Cochrane Library and EMBASE electronic databases were searched until August 2019. Eligible studies were analysed for comparison of oncological outcomes between RG and LG in patients with gastric cancer. RESULTS: Eleven retrospective comparative studies, which included 1347 (32.52%) patients in the RG group and 2795 (67.48%) patients in the LG group, were selected for the analysis. Meta-analysis of the 11 included studies showed that there was no statistically significant difference in the OS between the RG and LG groups (hazard ratios [HRs] = 0.97, 95% confidence intervals [CIs] = 0.80-1.19, P = 0.80). Six studies evaluated disease-free survival (DFS), and pooled analysis showed that there was no statistically significant difference in DFS between RG group and LG group (HR = 0.94, 95% CIs = 0.72-1.23, P = 0.65). According to the odds ratio (OR) analysis, there was no significant difference in 3-year OS, 5-year OS, 3-year DFS and 5-year DFS between the RG and LG groups. Nine articles reported the recurrence rate, and the meta-analysis showed that there was no statistically significant difference between the RG and LG groups (OR = 0.88, 95% CIs = 0.69-1.12, P = 0.31). CONCLUSIONS: This meta-analysis indicated that the long-term oncological outcomes in the RG group were similar to that in the LG group.

[The protective effects of SB203580 against mortality and radiation induced intestinal injury of mice].

This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups: control, total body irradiation exposure (IR, 7.2 Gy) only, and IR (7.2 Gy) + SB203580 (15 mg x kg(-1)). 30 days survival rate was observed in the experiment. In intestinal injury experiment, the expression levels of caspase-3, Ki67, p53 and p-p38 were assayed in the mice intestine crypts. The results showed that the 30 days survival rate was 100% (control), 0 (IR) and 40% (IR+ SB203580), separately. Compared to the IR groups, the positive cells of caspase-3, p53 and p-p38 in crypt cells decreased 33.00%, 21.78% and 34.63%, respectively. The rate of positive cells of Ki67 increased 37.96%. Significant difference was found between all of them (P < 0.01). SB203580 potently protected against radiation-induced lethal and intestinal injury in mice, and it may be a potential radio protector.

Ebola Therapeutic Study and Future Directions.

The constant Ebola epidemic outbreaks in Africa arisen in waves of panic worldwide. There is a high mortality rate (30-70%) among the Ebola-infected people in virus- stricken areas. Despite these horrors, the medical capabilities against this deadly viral disease were provided by limited therapeutic agents/options. As a result, several patented agents, biotherapies or prophylactic/therapeutic vaccines need to be reviving into the global markets-including patents of small molecular chemicals, short sequences or oligomers of DNA/RNA, linkages of chemicals with bio-molecules, herbal medicine and so on. In addition, the possible mechanisms of action of these therapeutic options are underway. To promote Ebola biomedical study, the multiple characters of Ebola infections-its origin, pathologic progress, genomic changes, therapeutic context and economic considerations are outlined in this review. Finally, a great difference can be expected after these types of efforts.

RETRACTED: Human Suicide, Modern Diagnosis Assistance and Magic Bullet Discovery

The article entitled "Human Suicide, Modern Diagnosis Assistance and Magic Bullet Discovery", by Da-Yong Lu, Peng- Peng Zhu, Hong-Ying Wu, Nagendra Sastry Yarla, Bin Xu, Jian Ding, Ajit Varki and Ting-Ren Lu, has been retracted on the request of the co-authors, Dr. Ajit Varki, Dr. Nagendra Sastry Yarla and Dr. Jian Ding available at: Cent Nerv Syst Agents Med Chem 2019; 19(1): 15-23. http://www.eurekaselect.com/169003/article.The Corresponding Author Dr. Da-Yong Lu has included the names of the co-authors, Dr. Ajit Varki, Dr. Nagendra Sastry Yarla and Dr. Jian Ding without their consent and the manuscript has been published in the journal, Central Nervous System Agents in Medicinal Chemistry (CNSAMC). Kindly see Bentham Science Policy on Article retraction at the link given below:(https://benthamscience.com/journals/central-nervous-system-agents-in-medicinal-chemistry/author-guidelines/)Submission of a manuscript to the respective journals implies that all authors have read and agreed to the content of the Copyright Letter or the Terms and Conditions. As such, this article represents a severe abuse of the scientific publishing system. Bentham Science Publishers takes a very strong view on this matter and apologizes to the readers of the journal for any inconvenience this may cause.

[Synthesis of CaLaAl3O7:Eu3+ by gel-combustion method and its luminescence properties].

Using the gel-combustion method the precursors of GaLa(1-x)Al3O7 : xEu3+ (0.05 < or = x < or = 0.8) were prepared. When annealing temperature was below 700 degrees C, the materials were in amorphous state, while as annealing temperature was above 800 degrees C, the high purity CaLa(1-x)Al3O7 : xEu3+ crystalline materials were obtained. The luminescence properties of GaLa(1-x)Al3O7 : xEu3+ both in amorphous and crystalline phases were investigated, and the results of excitation spectrum show a similar charge transition band of Eu3+--O2- between 230 nm and 320 nm and a series of f--f transition of Eu3+ ion. However, the strongest band of amorphous material was at 465 nm corresponding to (7)F0--(5)D2 transition, and those of the crystalline materials were at 394 nm corresponding to (7)F0--(5)L6 transition of Eu3+ ion. In amorphous state materials the emission intensity of excitation wavelength 465 nm was stronger than that of 394 nm, and composition of (5)D0--(7)F0 transition at 578 rim, (5)D0--(7)F1 transition at 587 rim and (5)D0--(7)F2 transition at 615 rim. In crystalline material, the emission intensity of excitation wavelength of 394 run was stronger than that of 465 rim, the (5)D0--(7)F0 transition disappeared, and the (5)D0--(7)F1 transition split into 587 rim and 596 rim. With the increase in temperature, the strongest band at 615 rim increased, and what is more, the (5)D0--(7)F1 transition increased remarkably. In CaLa(1-x)Al3O7 : xEu3+, when x=0.2 for the co-doping Eu3+ ion and the mol proportion of citric acid and metal ion (C/M) was 1.2, the luminescence intensity was the highest.

HAART in HIV/AIDS Treatments: Future Trends.

AIDS (acquired immune deficient syndrome) is a deadly human viral infectious disease caused by HIV (human immune-deficient virus) infection. Almost every AIDS patient losses his/her life before mid 1990s. AIDS was once the 1st disease killer in US (1993). After one decade hard work, antiviral drug cocktails-high active anti-retroviral therapy (HAART) have been invented for almost all HIV infection treatments. Due to the invention of HAART, 80-90% HIV/AIDS patients still effectively response to HAART for deadly AIDS episode controls and life saving. Yet, this type of HIV therapeutics is incurable. HIV/AIDS patients need to take HAART medications regularly and even life-long. To counteract this therapeutic drawback, more revolutionary efforts (different angles of therapeutic modes/attempts) are urgently needed. In this article, the major progresses and drawbacks of HIV/AIDS chemotherapy (HAART) to HIV/AIDS patients have been discussed. Future trends (updating pathogenesis study, next generations of drug developments, new drug target discovery, different scientific disciplinary and so on) are highlighted.

Human Suicide Risk and Treatment Study.

INTRODUCTION: Suicide is still a major event of human mortality worldwide. Yet human suicide prediction, prevention and therapeutic systems at this moment are generally ineffective in the clinic. No diagnostic system is reliable for significantly suicidal prevention and mortality reduction. As a result, human suicide etiopathologic investigation (especially at genetic/molecular levels in the clinical settings) is quite necessary. In order to boost human suicide researches, emerging human suicide diagnostic/treatment study will be transformed from clinical symptom observations into new generations of candidate drug targets and therapeutics. To achieve this goal, associations between suicidal etiopathologic identification, genetic/bioinformatics-based diagnostics and putative drug targets must be exploited than ever before. After all, the interaction and relationships between environmental/ genetic/molecular clues and overall patient's risk prediction (environmental influences and different therapeutic targets/types) should be found out. CONCLUSION: In the future, effective clinical suicide prediction, prevention and therapeutic systems can be established via scientific expeditions and causality discovery.

HIV/AIDS Curable Study: New Forms of Therapeutic Trinity.

BACKGROUND AND AIMS: AIDS (acquired immune deficient syndrome), a deadly human infectious disease is caused by HIV (human immunodeficiency viruses) infection. Patient's mortality was eventually reduced to one-fourth by combined chemotherapy (usually 3 chemical drugs simultaneously) than earlier HIV/AIDS treatments (single drug or vaccine) in the clinic. RESULTS: Combined treatments against HIV/AIDS are still incurable for all patients despite a high rate of patient's survival. Basic viral pathological study and advancing drug development systems for curable medications are indispensable nowadays and in the future. CONCLUSION: Up to date, therapeutic trinity (combined therapy) against HIV/AIDS is generally among chemical drugs. In this article, several forms of other therapeutic attempts for effectively curing efforts against HIV/AIDS are proposed-including the development of next generation therapeutic HIV vaccines and schedules, new categories of bio-therapy, different pathways of immune-modulation, herbal medicines in general (allopathic, Ayurveda and traditional Chinese medicines), high quality of physical exercises, and especially therapeutic combinations guided by latest medical discovery and principles (new forms of therapeutic trinity against HIV-induced pathogenesis and human mortality).

[Effects of different ligands on the fluorescence intensity of Tb(III)].

The excitation and emission spectra of seven Tb3+ complexes were measured and investigated, especially by comparing their fluorescence intensities. The effect of different ligands on the fluorescence intensity of Tb3+ was analyzed in terms of ligand structure, energy transfer and energies matching. The result indicates that ligands do not influence the positions of characteristic emission peaks of Tb3+, but the emission intensity. The research shows that the better the conjugative effect and rigidity of the ligand, the stronger the fluorescence intensity of the complex. In addition, binary acid strengthens the fluorescence intensity more efficiently than monoatomic acid. Eventually, the IR and Raman spectra of seven complexes of Tb were discussed.

Cancer Bioinformatics for Updating Anticancer Drug Developments and Personalized Therapeutics.

BACKGROUND: Last two to three decades, this world witnesses a rapid progress of biomarkers and bioinformatics technologies. Cancer bioinformatics is one of such important omics branches for experimental/clinical studies and applications. METHODS: Same as other biological techniques or systems, bioinformatics techniques will be widely used. But they are presently not omni-potent. Despite great popularity and improvements, cancer bioinformatics has its own limitations and shortcomings at this stage of technical advancements. RESULTS: This article will offer a panorama of bioinformatics in cancer researches and clinical therapeutic applications-possible advantages and limitations relating to cancer therapeutics. A lot of beneficial capabilities and outcomes have been described. As a result, a successful new era for cancer bioinformatics is waiting for us if we can adhere on scientific studies of cancer bioinformatics in malignant- origin mining, medical verifications and clinical diagnostic applications. CONCLUSION: Cancer bioinformatics gave a great significance in disease diagnosis and therapeutic predictions. Many creative ideas and future perspectives are highlighted.

Anticancer Drug Combinations, How Far We can Go Through?

Many clinical cancer therapies are less effective by using one anticancer drug only due to refractory properties of cancer pathogenesis and drug resistance property in advanced cancer patients. A general consensus among clinicians is that anticancer drug cocktail might better control cancer progresses and metastasis than single drug therapeutics in clinical trials. Despite great popularity, the anticancer drug combination dogma has not been established. The complexity of drug combination dogma discovery is more than we can expect now. This article speculates possible routes we can undertake in this matter. The background knowledge of drug combination therapy presently practiced and possible future landscapes and drawbacks of cancer drug combinative therapies are highlighted.

Drug Combination in Clinical Cancer Treatments.

AIM: The modality of anticancer drug combinations needs to be renovated from empirical into technical-supportive systems. METHODS: To challenge past therapeutic routines, the new landscape may be established. Among the different areas of anticancer drug combination study, research in the fields of medical study is the most important one-including disciplinary of therapeutics in different cancer stages, modern genetic/ molecular diagnostics, cancer bioinformatics, traditional Chinese medicine, mathematical data analysis, therapeutic toxicity monitor, personalized cancer medicine and so on. DISCUSSION: This article addresses these types of cancer therapeutic management systems for clinical anticancer drug combination utilities. CONCLUSION: Future cancer drug combinational studies and clinical optimums must be implemented.

[Structure and luminescence properties of Eu3+ complexes with benzoic acid and 1,10-phenanthroline incorporated in SiO2, SiO2-B2O3 and SiO2-B2O3-Na2O matrices].

Eu3+ Complexes with benzoic acid and 1,10-phenanthroline incorporated in SiO2, SiO2-B2O3 and SiO2-B2O3-Na2O matrices were prepared via the sol-gel method. Eu-doped SiO2, SiO2-B2O3 and SiO2-B2O3-Na2O luminescence materials were synthesized. The luminescence of Eu3+ was studied with excitation spectra and emission spectra. Different forms of dopants could influence the luminescence properties. The structure of Eu-doped glass was studied by comparing IR, TEM and XRD. The results showed that after the materials were annealed at 1 000 degrees C the structure was very stable because ingredient was already removed totally. The emission spectrum showed that the typical optical spectrum of Eu3+ is 5D0 --> 7Fj (j = 1, 2) at 588 nm and 614 nm. Comparing EuCl3 with Eu3+ complexes with benzoic acid and 1,10-phenanthroline as dopant, the latter has strong luminescence property though it has small mass fraction. The luminescence intensity of Eu(3+)-doped SiO2-B2O3 glass material was weaker than that of Eu(3+)-doped SiO2 glass material, and the former's spectrum showed that there were Si-O-B bonds. The luminescence intensity of Eu3+ was quenched by this kind of structure. The luminescence intensity of Eu(3+)-doped SiO2-B2O3-Na2O glass material was greatly increased, and the infrared spectrum illustrated that there was not vibration absorption of Si-O-B bonds. Probably Na replaced B, and Si-O-Na bonds formed. This kind of structure could enhance luminescence intensity of Eu3+ to some extend.

HIV Vaccination, is Breakthrough Underway?

After long defeats-almost no marked breakthrough in HIV vaccination campaign has been observed during the past two decades, and we still have not lost our faiths for the development of highly effective and low risk HIV vaccines. Many effective vaccines have been discovered and will certainly enter into the markets within the next 5 to 10 years. In order to promote HIV vaccine developments and clinical HIV therapeutic improvements, this perspective addresses the good and bad sides of currently available HIV vaccines, discusses many subjects of medical significance and finally provides up-to-date information in the field of HIV studies, in particular regarding vaccine developments and HIV pathogenesis.

HIV Vaccine for Prevention and Cure, A Mission Possible.

HIV/AIDS was once a highly deadly infective disease that killed the global people of a million annually two decades ago. While we are enjoying the HIV therapeutic advances (mostly important from HAART invention), one obvious drawback is still unresolved-unable to clearance all HIV from infected human bodies. As a result, a series of different therapeutic attempts have been proposed based on present knowledge of different features of HIV-induced pathogenesis and human mortalities. Facing this shortcoming, innovative designs and update of HIV vaccines and other types of HIV therapeutic inventions can be a final solution for completely HIV clearance and infection managements in human beings. Owing to these scientific and medical significances, several experimental and clinical attempts have to be made. Among these attempts, part of them (updating HIV vaccine developments and clinical routines) are quite promising and noteworthy. In this article, we offer the general information of this attempt and discuss it separately, especially on the respects of HIV vaccine strategic innovations.

[Synthesis, characterization and fluorescence properties of binary and ternary rare earth complexes with N-phenylanthranilic acid and 1, 10-phenanthroline].

Some novel binary and ternary complexes of rare earth (Tb) with N-phenylanthranilic acid and 1,10-phenanthroline were synthesized and their compositions were characterized by elemental analysis. The compositions of the complexes have been confirmed to be TbL3. 4H2O and TbL3 phen.2H20 (L: N-phenylanthranilic acid, phen: 1;10-phenanthroline). The spectroscopic properties of the complexes were discussed. The result shows that the luminescence intensities of binary and ternary complexes were decreased by N-phenylanthranilic acid and 1,10-phenanthroline. It is indicated that the intensity of Tb depends on the structure of ligands. The structure, energy transfer and energy matching were studied, and it is concluded that the structure of complex affects the luminescence properties of the complexes.

[Synthesis and luminescence properties of europium (III ) complexes with camphoric acid and 1,10-phenanthroline].

The complexes of europium(II) with camphoric acid and 1,10-phenanthroline have been synthesized and characterized by elemental analysis, (1)H NMR, IR and FT-Raman. The compositions of the complexes have been confirmed to be Eu2 (CA)3.(2)H2O and Eu2 (CA)3 (phen)2 (CA: camphoric acid, phen: 1, 10-phenanthroline). In addition, the camphoric acid and 1, 10-phenanthrolinemixed coordination compounds of Eu3+ -La3+ have been synthesized. Three-dimensional fluorescence spectra showed that the optimum excitation wavelength was 310 nm, and the strongest emission wavelength was 612 nm. When 310 nm light was used as an excitation wavelength, the seven bands due to (5)D0 - (7) F0 (579 nm), (5)D0 - (7)F1 (594 nm), (5)D0 - (7)F2 (612 and 620 nm), (5)D0 - (7)F3 (650 nm) and (5)D0 - (7)F4 (689 and 697 nm) were observed between 550-700 nm, in which (5)D0 - (7)F2 transitions contain two lines (612 and 620 nm), and (5)D0 - (7)F4 transitions also contain two lines (689 and 697 nm). The excitation spectra showed that excitation band was from 240 to 340 nm, and the maximum was at about 310 nm. The fluorescence studies on all of samples showed that the fluorescence intensities of europium ions were sensitized by lanthanum ions, but the peak position of their emission band did not shift obviously.

[Study on the transition of green, yellow fluorescence of ternary complexes of Tb-benzoic acid-1,10-phenanthroline].

In this paper, ternary solid complexes of Tb-benzioc acid-1,10-phenanthroline have been synthesized. Compared with binary complexes of Tb-benzioc acid, their properties were investigated. The results showed that the second ligand-phenanthroline enhanced the fluorescence intensities of Tb3+, and shortened its fluorescence lifetime, and it was found that the aggregative state influenced the luminescence properties of ternary complexes. When particulates dispersed to a certain degree, the probability of 5D4-->7F5 transition of Tb3+ was great, so, green fluorescence was observed for the complexes. With the aggregation of particles, the probability of 5D4-->7F5 transition of Tb3+ decreased, while the probability of D4-->7F3 transition increased. Therefore, ternary complexes of Tb-benzoic acid-1,10-phenanthroline exhibited yellow fluorescence. In addition, spectroscopic properties of the complexes were investigated.

[Preparation and spectroscopic properties of terbium polypropenic acid film].

The bonding-type rare earth polymers-polypropenic-acid terbium film was prepared through the bonding way. Three-dimension fluorescence spectra showed that the optimum excitation wavelength was 306 nm, the strongest emission wavelength was 544 nm. The terbium polypropenic-acid film showed the characteristic Tb3+ emission when excited at 306 nm due to 5D4-7FJ transition (J = 6, 5, 4 and 3). The emission maximum at 544 nm was ascribed to 5D4-7F5 transition of Tb3+ and presented strong green emission. The luminescent properties of Tb3+ were not affected by polymerism of propenic-acid and the transparency of polypropenic-acid in visible light region was not affected by the dopping Tb3+. The fluorescence properties and spectroscopic properties of the terbium polypropenic-acid were investigated by excitation spectrum, emission spectrum, IR, far-IR, and Raman spectrum.