Detalhe da pesquisa
1.
Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC.
Respir Res
; 23(1): 272, 2022 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36183104
2.
Establishment of a novel, cell-based autotaxin assay.
Anal Biochem
; 630: 114322, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34343482
3.
Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction.
Circ Res
; 120(1): 120-132, 2017 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27799254
4.
Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Development
; 141(18): 3594-604, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25183874
5.
Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase.
Proc Natl Acad Sci U S A
; 111(24): 8803-8, 2014 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24889611
6.
Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.
Biol Reprod
; 94(5): 110, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27009040
7.
Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production.
Biochem J
; 454(3): 515-23, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23841650
8.
Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes.
Dev Biol
; 366(2): 308-16, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22546688
9.
Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter cell lines.
Mol Pharm
; 10(10): 3697-705, 2013 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23987244
10.
Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY-747 designed for the treatment of resistant hypertension.
Br J Pharmacol
; 180(19): 2500-2513, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37170767
11.
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist.
J Med Chem
; 66(7): 4659-4670, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36932954
12.
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
J Med Chem
; 66(11): 7280-7303, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37040336
13.
Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm.
J Biol Chem
; 286(19): 17311-25, 2011 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454470
14.
BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor.
J Med Chem
; 65(24): 16420-16431, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475653
15.
Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation.
Nat Cardiovasc Res
; 1(12): 1174-1186, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37484062
16.
A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.
PLoS Comput Biol
; 6(1): e1000648, 2010 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20098496
17.
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042).
J Med Chem
; 64(9): 5323-5344, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872507
18.
Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells.
Am J Physiol Renal Physiol
; 297(3): F693-703, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19570884
19.
Development of a novel, sensitive cell-based corin assay.
Biochem Pharmacol
; 160: 62-70, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553787
20.
Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines.
Mol Pharmacol
; 73(4): 1235-43, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18174292