Three Zn(ii)-based MOFs for luminescence sensing of Fe3+ and Cr2O72- ions.

Three zinc metal-organic frameworks (MOFs), {ZnL(chd)}n (1), {[Zn(L)0.5(oba)]·DMF·H2O}n (2) and {[Zn(L)0.5(sdb)]·H2O}n (3) [L = E,E-2,5-dihexyloxy-1,4-bis-(2-pyridin-vinyl)-benzene; H2chd = 1,4-cyclohexanedicarboxylic acid, H2oba = 4,4'-oxybisbenzoic acid, H2sdb = 4,4'-sulfonyldibenzoic acid], have been hydrothermally synthesized. We explored their applications in detecting ions, and the result shows that they all show highly selective sensing for Fe3+ and Cr2O72- ions.

Analogues of xanthones--Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates.

Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as α-glucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro. Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards α-glucosidase with noncompetitive mechanism. Moreover, most of the hydroxy bis-chalcones exhibit good α-glucosidase inhibitory activities in enzyme test. Inspiringly, bis-chalcones 2g (at 1 µM concentration) has stronger effect than 1-deoxynojirimycin on reducing the glucose level in HepG-2 cells (human liver cancer cell line).