Retrospective evaluation of the endovascular repair of the anastomotic pseudoaneurysm of the transplanted renal artery using the snorkel technique.

OBJECTIVE: To evaluate the endovascular repair of the transplanted renal artery anastomotic pseudoaneurysm using the snorkel technique. METHODS: From April 2012 to December 2017, we performed endovascular repair in six patients, who were diagnosed with transplanted renal artery anastomotic pseudoaneurysm, using the snorkel technique. The "snorkel" stent and the "parallel" stent were placed in the transplanted kidney and the external iliac artery, respectively. Another covered stent was implanted at the proximal end of the external iliac artery to match the diameter of the iliac artery.Result and conclusion: Of the six patients, three patients recovered. Two patients experienced pseudoaneurysm rupture due to infection, and one patient developed stent thrombosis; all three patients underwent graft nephrectomy. The endovascular treatment of transplanted renal artery anastomotic pseudoaneurysm with the snorkel technique is a feasible method but needs to comply with certain indications.

A Multi-Label Text Classifier at Publication Level Based on "PubMedBERT + TextRNN" for Cancer Literature.

There is a rapid growth in the volume of data in the cancer field and fine-grained classification is in high demand especially for interdisciplinary and collaborative research. There is thus a need to establish a multi-label classifier with higher resolution to reduce the burden of screening articles for clinical relevance. This research trains a multi-label classifier with scalability for classifying literature on cancer research directly at the publication level. Firstly, a corpus was divided into a training set and a testing set at a ratio of 7:3. Secondly, we compared the performance of classifiers developed by "PubMedBERT + TextRNN" and "BioBERT + TextRNN" with ICRP CT. Finally, the classifier was obtained based on the optimal combination "PubMedBERT + TextRNN", with P= 0.952014, R=0.936696, F1=0.931664. The quantitative comparisons demonstrate that the resulting classifier is fit for high-resolution classification of cancer literature at the publication level to support accurate retrieving and academic statistics.

Case report: Immunotherapy plus chemotherapy and stereotactic ablative radiotherapy (ICSABR): a novel treatment combination for Epstein-Barr virus-associated lymphoepithelioma-like intrahepatic cholangiocarcinoma.

Epstein-Barr virus-associated lymphoepithelioma-like intrahepatic cholangiocarcinoma (EBVa LEL-ICC) is a rare tumor, characterized by a rich tumor immune microenvironment (TIME). While this tumor is reportedly sensitive to immunotherapy, its response has been inconsistent. This decreased sensitivity was associated with reduced TIME abundance. We report the case of a 53-year-old woman with EBVa LEL-ICC having reduced TIME abundance. The patient presented with a liver lesion, which was detected using ultrasound. Initially, the tumor was sensitive to immunotherapy and chemotherapy (IC), but resistance developed after a short interval. Subsequently, stereotactic ablative radiotherapy (SABR) was added to the patient's treatment, which now consisted of ICSABR. Successful tumor shrinkage was achieved with the combination therapy regimen. Thus, surgery and ICSABR are effective adjuncts to the first-line IC therapy in improving the survival rate of patients with EBVa LEL-ICC. The results of this study support multidisciplinary treatment as a viable treatment strategy for EBVa LEL-ICC.

The analysis of clinical manifestations and genetic mutations in Chinese boys with primary adrenal insufficiency.

OBJECTIVES: To analyze the clinical manifestations of primary adrenal insufficiency in Chinese boys, to investigate the prevalence of DAX1 and SF1 gene mutations, and to explore the association between gene mutations and clinical manifestations. SUBJECTS AND METHODS: A total of 25 boys with primary adrenal insufficiency were enrolled. Mutational analysis of the DAX1 and SF1 genes was done by direct sequencing. RESULTS: DAX1 gene mutations were found in 40% (10 of 25) of 46,XY phenotypic boys referred with adrenal insufficiency, and six of these were novel. One SF1 gene mutation was identified. These patients demonstrated diverse clinical presentations. There was no definite association between clinical manifestations and genetic mutations. CONCLUSIONS: DAX1 gene mutations are a relatively frequent cause of primary adrenal insufficiency. In contrast, mutation in the SF1 gene is seldom found. There is no definite relationship between gene mutations and clinical manifestations.

Medical Big Data and Postoperative Nursing of Fracture Patients Based on Cloud Computing.

Based on the standards for wireless sensor system identification, the sensor node identity OID identification and the management object OID identification in the SNMP MIB are merged, and a management object OID identification coding mechanism for the SNMP-based wireless sensor system is proposed to make the node management system only. The identity, attributes, and multiple entities of the target sensor node in the wireless sensor network can be identified and managed by the node management object OID. The source of abnormal medical big data generally uses two models of multidimensional data and sliding window for detection and verification. First, the sliding window can be used to detect abnormalities. The result is that under this condition, the detection rate of medical big data is more than 95%; the effect is very good, but in different dimensions, the detection rate of four-dimensional data is 2.9% higher than that of a single-dimensional one. On the basis of the ZigBee wireless network, the terminal signal transmission of fracture treatment can be realized. On this basis, combined with the actual needs of fracture treatment, it can be built with its wireless module. The wireless network has a certain basic function. The reform of the nursing system was carried out on the basis of the safety and reliability of the nursing system, the efficiency of the nursing system was improved, and timely and safe nursing services were achieved.

Association between ACVR2A gene polymorphisms and risk of hypertensive disorders of pregnancy in the northern Chinese population.

INTRODUCTION: To investigate the possible roles of selected single-nucleotide gene polymorphisms (SNPs) of the activin A receptor type 2A (ACVR2A) gene in the pathogenesis of hypertensive disorders of pregnancy (HDP). METHODS: In this study, the six SNPs of the ACVR2A gene were analyzed by multiplex polymerase chain reaction (PCR) combined with next-generation sequencing methods in 186 HDP patients and 380 healthy pregnant women. Multivariate logistic regression analysis combined with 10,000 permutation tests was used to analyze the potential relationship between ACVR2A gene polymorphisms and HDP, especially its subset pre-eclampsia. RESULTS: Our findings showed that the rs1424954, rs1014064, rs1128919, and rs3768687 differed significantly between HDP patients and control group (p = 0.035, p = 0.035, p = 0.024 and p = 0.035, respectively), which remained significant after 10,000 permutation tests. In addition, rs1424954, rs1014064, rs1128919, rs3768687, rs3764955, and rs13430086 were all statistically significant among the PE patients compared with the controls (p = 0.013, p = 0.016, p = 0.018, p = 0.019, p = 0.024 and p = 0.029, respectively). The significance still existed after 10,000 permutation tests. DISCUSSION: ACVR2A gene polymorphisms may play a role in the pathogenesis of HDP and its subset PE.

Identification of Chinese Hospitalized Patients' Risk Profile for Venous Thromboembolism (DissolVE1): A Study Protocol of a Non-Interventional Registry Study.

INTRODUCTION: Venous thromboembolism (VTE) is a frequent cause of hospitalization, mortality, and long-term adverse consequence among medical and surgical inpatients. The current study is performed to identify the prophylaxis of patients with VTE risk within the 6 weeks prior to the diagnosis of VTE, and the treatment pattern during 3 months after VTE diagnosis in Chinese patients hospitalized for surgeries or medical illness. METHODS: This multicenter, non-interventional, observational registry plans to enroll 1200 patients from 40 centers in China. The study will retrospectively collect data from patients' hospitalization record within 6 weeks of VTE diagnosis and prospectively follow-up patients for 3 months (in four visits). The primary outcome is to determine the percentage of patients receiving adequate prophylaxis in patients hospitalized within 6 weeks before VTE diagnosis and treatment pattern within 3 months after VTE diagnosis. Important secondary endpoints include determining patients with risk of VTE in the hospital setting, risk factors for VTE, and cost analysis of VTE treatment. EXPECTED OUTCOMES: The findings will determine the characteristics of VTE, its treatment practices, cost of treatment, and quality of life in patients; this information may help in building diagnostic and prophylaxis strategies for VTE in China. TRIAL REGISTRATION: The study is registered in the Venous Thromboembolism Registry in China with study number DIREGL07581. FUNDING: Sanofi China.