Cooperative Spectrum Sensing Based on Multi-Features Combination Network in Cognitive Radio Network.

Cognitive radio, as a key technology to improve the utilization of radio spectrum, acquired much attention. Moreover, spectrum sensing has an irreplaceable position in the field of cognitive radio and was widely studied. The convolutional neural networks (CNNs) and the gate recurrent unit (GRU) are complementary in their modelling capabilities. In this paper, we introduce a CNN-GRU network to obtain the local information for single-node spectrum sensing, in which CNN is used to extract spatial feature and GRU is used to extract the temporal feature. Then, the combination network receives the features extracted by the CNN-GRU network to achieve multifeatures combination and obtains the final cooperation result. The cooperative spectrum sensing scheme based on Multifeatures Combination Network enhances the sensing reliability by fusing the local information from different sensing nodes. To accommodate the detection of multiple types of signals, we generated 8 kinds of modulation types to train the model. Theoretical analysis and simulation results show that the cooperative spectrum sensing algorithm proposed in this paper improved detection performance with no prior knowledge about the information of primary user or channel state. Our proposed method achieved competitive performance under the condition of large dynamic signal-to-noise ratio.

Risk factors and protective factors for nonsuicidal self-injury in adolescents: A hospital- and school-based case-control study.

OBJECTIVE: Nonsuicidal Self-Injury (NSSI) in China has increasingly interested clinicians, although few studies have investigated its risk and protective factors. This study examined the risk factors of NSSI among Chinese adolescents. METHODS: The researchers recruited adolescent participants with NSSI from a hospital outpatient clinic to form a case group and recruited adolescents without NSSI who provided informed consent from the school to form a control group. Participants completed a questionnaire, and data were analyzed using logistic regression. RESULTS: A total of 138 cases and 276 controls participated in this study. Binary multivariate logistic regression analysis with adjusting for age and sex showed that domestic violence (OR = 8.615, 95%CI: 3.081-24.091), parental overconcern (OR = 6.995, 95%CI: 3.447-14.192), guilt (OR = 4.949, 95%CI: 2.227-10.996), and school bullying (OR = 21.676, 95%CI: 6.799-69.109) increased the risk of NSSI, while peer support (OR = 0.068, 95%CI: 0.030-0.150) and living in an urban environment (OR = 0.157, 95%CI: 0.056-0.437) decreased the risk of NSSI. CONCLUSION: Some psychosocial factors were confirmed to be independent risk and protective factors for NSSI in this study. However, the clinical significance of the results needs to be interpreted with caution due to sample size limitations.

Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo.

G protein-coupled receptor (GPCR) heterodimers are new targets for the treatment of depression. Increasing evidence supports the importance of serotonergic and orexin-producing neurons in numerous physiological processes, possibly via a crucial interaction between 5-hydroxytryptamine 1A receptor (5-HT1AR) and orexin receptor 1 (OX1R). However, little is known about the function of 5-HT1AR/OX1R heterodimers. It is unclear how the transmembrane domains (TMs) of the dimer affect its function and whether its modulation mediates antidepressant-like effects. Here, we examined the mechanism of 5-HT1AR/OX1R dimerization and downstream G protein-dependent signaling. We found that 5-HT1AR and OX1R form constitutive heterodimers that induce novel G protein-dependent signaling, and that this heterodimerization does not affect recruitment of ß-arrestins to the complex. In addition, we found that the structural interface of the active 5-HT1AR/OX1R dimer transforms from TM4/TM5 in the basal state to TM6 in the active conformation. We also used mutation analyses to identify key residues at the interface (5-HT1AR R1514.40, 5-HT1AR Y1985.41, and OX1R L2305.54). Injection of chronic unpredictable mild stress (CUMS) rats with TM4/TM5 peptides improved their depression-like emotional status and decreased the number of endogenous 5-HT1AR/OX1R heterodimers in the rat brain. These antidepressant effects may be mediated by upregulation of BDNF levels and enhanced phosphorylation and activation of CREB in the hippocampus and medial prefrontal cortex. This study provides evidence that 5-HT1AR/OX1R heterodimers are involved in the pathological process of depression. Peptides including TMs of the 5-HT1AR/OX1R heterodimer interface are candidates for the development of compounds with fast-acting antidepressant-like effects.

A biologically motivated signal transmission approach based on stochastic delay differential equation.

Based on the stochastic delay differential equation (SDDE) modeling of neural networks, we propose an effective signal transmission approach along the neurons in such a network. Utilizing the linear relationship between the delay time and the variance of the SDDE system output, the transmitting side encodes a message as a modulation of the delay time and the receiving end decodes the message by tracking the delay time, which is equivalent to estimating the variance of the received signal. This signal transmission approach turns out to follow the principle of the spread spectrum technique used in wireless and wireline wideband communications but in the analog domain rather than digital. We hope the proposed method might help to explain some activities in biological systems. The idea can further be extended to engineering applications. The error performance of the communication scheme is also evaluated here.

Flower-like Fe7S8/Bi2S3 superstructures with improved near-infrared absorption for efficient chemo-photothermal therapy.

Although various photothermal therapy (PTT) nanoagents have been developed in recent years, the rational design and easy synthesis of a PTT nanoplatform with improved near-infrared (NIR) absorption have remained challenging. Herein, via a facile one-pot solvothermal strategy, hydrophilic nanosheet-assembled flower-like Fe7S8/Bi2S3 superstructures were fabricated successfully. Such nanoflowers exhibit improved NIR absorption, which is 1.54 times higher than that of pure Bi2S3 nanosheets at a wavelength of 808 nm. Attractively, these nanoflowers could serve as a drug delivery carrier with controlled release under pH/NIR stimuli and display a fascinating chemo-photothermal synergetic therapeutic effect both in vitro and vivo. The resulting nanoflowers may open up a way for the design of other nanoagents with an improved NIR absorption and chemo-photothermal cancer therapy effect.

UV and visible light synergetic photodegradation using rutile TiO2 nanorod arrays based on a p-n Junction.

Herein, we report a photocatalytic heterojunction device of rutile TiO2 nanorod arrays based on a p-n silicon junction (TiO2@PN) and its full absorption of ultraviolet and visible light for synergistic photodegradation. The fabricated TiO2@PN had excellent photocatalytic degradation of methyl orange (MO) under irradiation of a 300 W Xe lamp, and its pseudo-first-order rate constant k was 0.221 h-1, which was greatly higher than that for TiO2 nanorod arrays based on an n-p silicon junction (TiO2@NP, 0.078 h-1) and glass (TiO2@G, 0.032 h-1). The higher photocatalytic performance of TiO2@PN could be attributed to the fact that the photovoltage (PV) of the p-n junction promotes separation of the electron-hole pairs of the TiO2, and the holes are thus left within the TiO2 nanorods to produce a strong oxidant of hydroxyl radicals (˙OH). Moreover, this heterojunction device could be easily fabricated in a large size for easy recovery and recycling, which shows its promise in the solar-driven degradation of environmental pollution.