Detalhe da pesquisa
1.
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Cell
; 145(7): 1075-87, 2011 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21683433
2.
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature
; 535(7611): 252-7, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27338790
3.
A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma.
Cancer
; 121(19): 3481-90, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26177599
4.
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation.
J Med Chem
; 66(23): 16388-16409, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991844
5.
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.
Mol Cell Biol
; 27(2): 510-7, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17101801
6.
Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S Checkpoint.
Mol Cancer Ther
; 17(8): 1727-1738, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866747
7.
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro.
Oncotarget
; 8(43): 74688-74702, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29088817
8.
In vitro SCFbeta-Trcp1-mediated IkappaBalpha ubiquitination assay for high-throughput screen.
Methods Enzymol
; 399: 729-40, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16338392
9.
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
Mol Cancer Ther
; 14(6): 1295-305, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855786
10.
The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.
Clin Cancer Res
; 19(20): 5722-32, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24030701
11.
Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase.
J Biol Chem
; 282(21): 15462-70, 2007 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17409098
12.
ERK1/2 MAP kinases in cell survival and apoptosis.
IUBMB Life
; 58(11): 621-31, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17085381
13.
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
Mol Cell
; 9(5): 945-56, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12049732
14.
Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation.
J Biol Chem
; 277(48): 45785-92, 2002 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12228228