Detalhe da pesquisa
1.
Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel.
Int J Mol Sci
; 23(23)2022 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499627
2.
Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).
Int J Mol Sci
; 23(21)2022 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36362047
3.
A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.
Mol Pharm
; 12(10): 3507-17, 2015 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26291333
4.
Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04.
J Med Chem
; 66(9): 6160-6183, 2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098275
5.
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
J Med Chem
; 55(5): 1999-2014, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22320402
6.
Design and syntheses of permethyl ningalin B analogues: potent multidrug resistance (MDR) reversal agents of cancer cells.
J Med Chem
; 53(14): 5108-20, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20560605
7.
Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships.
ChemMedChem
; 4(4): 594-614, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19288491