Demonstration of a Rayleigh-Brillouin scattering spectrometer with a high spectral resolution for rapid gas temperature detection.

A novel, to the best of our knowledge, Rayleigh-Brillouin scattering (RBS) spectrometer based on a virtually imaged phased array (VIPA) with a high spectral resolution is proposed for rapid gas temperature detection. CO2 RBS spectra at gas pressure of 0.5-4 bar were acquired with a spectrum acquisition time of 10 s, and temperature inversion analysis was performed using TENTI S6 model. The root-mean-square error (RMSE) of the RBS profile fitting is less than 2.95%, and the maximum absolute error of temperature inversion is less than 2.45 K. Compared with traditional methods, this method has low RBS signal loss and short acquisition time without the frequency scanning process, which is more conducive to real-time detection applications.

Cannabidiol administration reduces sublesional cancellous bone loss in rats with severe spinal cord injury.

Patients with spinal cord injury (SCI) undergo severe loss of bone mineral below the level of lesion, and data on available treatment options after SCI is scarce. The aim of this work was to investigate the therapeutic effect of cannabidiol (CBD), a non-psychoactive cannabis, on sublesional bone loss in a rat model of SCI. The adult male rats were exposed to surgical transection of the cord and treated with CBD for consecutive 14 days. It was found that CBD treatment elevated the serum levels of osteocalcin, reduced the serum levels of collagen type I cross-linked C-telopeptide, and enhanced bone mineral density of tibiae and femurs. Treatment of SCI rats with CBD enhanced bone volume, trabecular thickness, and trabecular number, and reduced trabecular separation in proximal tibiae, and increased ultimate compressive load, stiffness, and energy to max force of femoral diaphysis. Treatment of SCI rats with CBD upregulated mRNA expression of alkaline phosphatase and osteoprotegerin and downregulated mRNA expression of receptor activator of NF-κB ligand and tartrate-resistant acid phosphatase in femurs. Furthermore, treatment of SCI rats with CBD enhanced mRNA expression of wnt3a, Lrp5 and ctnnb1 in femurs. In conclusion, CBD administration attenuated SCI-induced sublesional cancellous bone loss.