Detalhe da pesquisa
1.
Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
Bioorg Med Chem
; 27(4): 579-588, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626555
2.
Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study.
Analyst
; 139(8): 1902-12, 2014 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24563904
3.
Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists.
Bioorg Med Chem Lett
; 22(9): 3366-9, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22460029
4.
Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD.
Bioorg Med Chem Lett
; 19(16): 4560-2, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19616944
5.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
J Med Chem
; 62(9): 4683-4702, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30973731
6.
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J Med Chem
; 59(8): 3991-4006, 2016 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27031670
7.
2H-Azirine 3-phosphonates: a new class of chiral iminodienophiles. Asymmetric synthesis of quaternary piperidine phosphonates.
Org Lett
; 4(4): 655-8, 2002 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-11843615
8.
Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.
J Med Chem
; 52(16): 5241-52, 2009 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19630384
9.
Asymmetric synthesis of aziridine 2-phosphonates from enantiopure sulfinimines (N-sulfinyl imines). Synthesis of alpha-amino phosphonates.
J Org Chem
; 68(6): 2410-9, 2003 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12636410