1.
Org Biomol Chem
; 16(5): 771-779, 2018 01 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29319096
RESUMO
An efficient diastereoselective approach to access the 3-hydroxy-2,6-disubstituted piperidine scaffold 1 has been developed through the Mannich process involving N,O-acetal (2S,3R)-6 and ketones in excellent yield with high diastereoselectivity (dr > 99 : 1). In addition, the utility of this convenient one-pot process is demonstrated by the asymmetric synthesis of (-)-sedacryptine 3.