Characteristics of Long-term Nonprogressors and Viremia Controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier.

To characterize long-term nonprogressors (LTNPs) and viremia controllers (VCs), infected with HIV-1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan, China. LTNPs and VCs were defined by CD4+T lymphocyte (CD4) count and viral load (VL). Of 29,294 patients infected with HIV-1 via contaminated blood donation or transfusion that had conducted for more than 20 years, 92 were LTNPs/VCs. There were 70 LTNPs (0.24%), 43 VCs (0.15%), and 48 LTNPs+VCs- (0.16%). VCs had a significantly lower CD4 nadir, compared to LTNPs and LTNPs+VCs-, and no significant differences for the highest VL and HIV-1 DNA. Cases P4 and P5 were LTNPs, while their VL reached approximately 4.3 log copies/mL. P6 was a VC, but with CD4 < 500 cells/µL constantly. Data from the LTNPs/VCs cohort provided valuable information, future research is needed.

[High resolution refractive index sensor based on the non-complete surface state of 1-D photonic crystal].

A novel refractive index sensor based on one-dimensional photonic crystal non-complete surface defect is introduced and the principle and the method of the sensor are discussed. The experiment system used to detect the refractive index was constructed to get high resolution and high Q-value. The sensor is verified by detecting the dimethyl sulphone solution. The experimental result indicates that this refractive index sensor's sensitivity is 3 025 nm x RIU(-1), and when the resolution of spectrometer is 0.01 nm the resolution of this sensor is 3.3 x 10(-6) RIU. The Q value of this sensor is 260, and the sensor has good linearity in 1.4-1.42 range (the linearity is 0.991 27). It was analyzed how the photonic crystal periodicity and liquid thickness affect the Q value of the sensor. The result proved that this kind of total reflection photonic crystal surface wave sensor is label free, which is similar with SPR sensor, and the sensor has high resolution, high Q-value and has real-time survey characteristic.