Detalhe da pesquisa
1.
New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies.
Bioorg Chem
; 135: 106487, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36996510
2.
Design, Synthesis, and Biological Evaluation of New 1H-Imidazole-2-Carboxylic Acid Derivatives as Metallo-ß-Lactamase Inhibitors.
Bioorg Med Chem
; 72: 116993, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36084491
3.
[Composition changes reveal relationship between color and enzymatic reaction of Magnoliae Officinalis Cortex during "sweating" process].
Zhongguo Zhong Yao Za Zhi
; 47(5): 1262-1272, 2022 Mar.
Artigo
em Zh
| MEDLINE | ID: mdl-35343153
4.
MeLAD: an integrated resource for metalloenzyme-ligand associations.
Bioinformatics
; 36(3): 904-909, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31504189
5.
Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-ß-lactamases.
Bioorg Med Chem Lett
; 41: 127956, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744439
6.
Principles and current strategies targeting metallo-ß-lactamase mediated antibacterial resistance.
Med Res Rev
; 40(5): 1558-1592, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32100311
7.
[Comparative transcriptome and proteome profiling of chlorophyll metabolism pathway in four types of Magnolia officinalis].
Zhongguo Zhong Yao Za Zhi
; 45(16): 3826-3836, 2020 Aug.
Artigo
em Zh
| MEDLINE | ID: mdl-32893577
8.
Metallo-ß-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery.
Trends Microbiol
; 31(7): 735-748, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36858862
9.
Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-ß-lactamase inhibitors.
Eur J Med Chem
; 257: 115473, 2023 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37209449
10.
Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-ß-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.
J Med Chem
; 66(19): 13746-13767, 2023 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37791640
11.
Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-ß-lactamase inhibitors.
Eur J Med Chem
; 228: 113965, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34763944
12.
ProfKin: A comprehensive web server for structure-based kinase profiling.
Eur J Med Chem
; 225: 113772, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34411891
13.
Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance.
Chem Commun (Camb)
; 57(62): 7709-7712, 2021 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34259249
14.
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Eur J Med Chem
; 225: 113803, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34461505
15.
Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-ß-lactamase inhibitors.
RSC Adv
; 10(52): 31377-31384, 2020 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35520685
16.
Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.
Eur J Med Chem
; 192: 112201, 2020 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32163813
17.
Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase.
Medchemcomm
; 10(1): 164-168, 2019 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30774863
18.
Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-ß-lactamases.
J Med Chem
; 62(15): 7160-7184, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31269398
19.
[Pollution Characteristics and Health Risk Assessment of Heavy Metals in Wheat Grains Cultivated in Kaifeng Irrigation Area of the Yellow River].
Huan Jing Ke Xue
; 39(8): 3917-3926, 2018 Aug 08.
Artigo
em Zh
| MEDLINE | ID: mdl-29998702
20.
[Dynamic response and variance of vegetation in China from 1982 to 2015 under the asymmetric rate of temperature fluctuation.] / 19822015å¹´æ¼å¤ä¸å¯¹ç§°å¢æ¸©ä¸ä¸å½èªç¶æ¤è¢«å¨æååºåå·®å¼.
Ying Yong Sheng Tai Xue Bao
; 29(7): 2362-2372, 2018 Jul.
Artigo
em Zh
| MEDLINE | ID: mdl-30039676