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The complex-enhanced hierarchical relationship among multiple stakeholders in the water-environment-agriculture interactive system has been overlooked. This study develops a leader-follower-enhanced framework (named as FCMLP) that integrates variable-weight combination prediction model, multi-level programming, and fuzzy credibility constrained programming, which can effectively address the above problems under uncertainties. Five water ecological carrying capacity (WECC) statuses are treated as a critical constraint into the modeling framework to improve the accuracy of decision-making. An interactive fuzzy satisfaction algorithm is advanced for solving this multi-level problem, in which COD discharge minimization, economic benefits maximization, and grain yield maximization are taken as the upper-, middle-, and lower-level goals, respectively. The framework is applied to plan the cross-regional water-environment-agriculture interactive system in the Beijing-Tianjin-Hebei and Yangtze River Economic Belt. Solutions reveal that increased WECC status and credibility level would decrease 1.40%-1.74%, 0.71%-9.61%, and 1.63%-2.26% of water resources allocation, COD emissions, and economic benefits, respectively. Crop area and grain yield would dramatically decline by 4.13%-4.46% and 4.03%-4.67% when a credibility level increases from 0.8 to 1, respectively. The overall satisfactory degree would range from 0.58 to 0.70, which illustrates interactive decision-making process of multiple stakeholders. Significant differences can be observed in the optimized schemes of water resources allocation and environmental-economic-agricultural performances among various models. The amounts of allocated water resources, pollutant discharge, and economic output from the FCMLP model would be respectively 11.30%-13.45%, 14.90%-15.21%, and 73.12%-73.48% higher than those from the environment- and agriculture-oriented schemes, yet 13.81%, 32.05%, and 15.29% lower than those from the economy-oriented scheme. Some water adaptability countermeasures are given for ensuring the scientific operation of the South-to-North Water Transfer Project and alleviating conflicts between water source and receiving areas. Further exploration of the optimization scheme of water-environment-energy-agriculture system driven by climate change is still required for guaranteeing the dynamic balance of regional resources.
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Agricultura , Agricultura/métodos , Conservação dos Recursos Naturais , Lógica Fuzzy , Recursos Hídricos , Água , Tomada de Decisões , EcologiaRESUMO
Ammonia (NH3 ) is a promising hydrogen (H2 ) carrier for future carbon-free energy systems, due to its high hydrogen content and easiness to be liquefied. Inexpensive and efficient catalysts for ammonia electro-oxidation reaction (AOR) are desired in whole ammonia-based energy systems. In this work, ultrasmall delafossite (CuFeO2 ) polyhedrons with exposed high-index facets are prepared by a one-step NH3 -assisted hydrothermal method, serving as AOR pre-catalysts. The high-index CuFeO2 facet is revealed to facilitate surface reconstruction into active Cu-doped FeOOH nanolayers during AOR processes in ammonia alkaline solutions, which is driven by the favorable Cu leaching and terminates as the 2p levels of internal lattice oxygen change. The reconstructed heterostructures of CuFeO2 and Cu-doped FeOOH effectively activate the dehydrogenation steps of NH3 and exhibit a potential improvement of 260 mV for electrocatalytic AOR at 10 mA cm-2 compared to the pre-restructured phase. Further, density functional theory (DFT) calculations confirm that a lower energy barrier of the rate-determining step (*NH3 to *NH2 ) is presented on high-index CuFeO2 facets covered with Cu-doped FeOOH nanolayers. Innovatively, lattice oxygen atoms in Fe-based oxides and oxyhydroxide are involved in the dehydrogenation steps of AOR as a proton acceptor, broadening the horizons for rational designs of AOR catalysts.
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The electrocatalytic nitrogen reduction reaction (NRR) to synthesize NH3 under ambient conditions is a promising alternative route to the conventional Haber-Bosch process, but it is still a great challenge to develop electrocatalysts' high Faraday efficiency and ammonia yield. Herein, a facile and efficient exfoliation strategy to synthesize ultrathin 2D boron and nitrogen co-doped porous carbon nanosheets (B/NC NS) via a metal-organic framework (MOF)-derived van der Waals superstructure, is reported. The results of experiments and theoretical calculations show that the doping of boron and nitrogen can modulate the electronic structure of the adjacent carbon atoms; which thus, promotes the competitive adsorption of nitrogen and reduces the energy required for ammonia synthesis. The B/NC NS exhibits excellent catalytic performance and stability in electrocatalytic NRR, with a yield rate of 153.4 µg·h-1 ·mg-1 cat and a Faraday efficiency of 33.1%, which is better than most of the reported NRR electrocatalysts. The ammonia yield of B/NC NS can maintain 92.7% of the initial NRR activity after 48 h stability test. The authors' controllable exfoliation strategy using MOF-derived van der Waals superstructure can provide a new insight for the synthesis of other 2D materials.
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Separating ethylene (C2 H4 ) from the C2 hydrocarbons is of prime industrial importance for the process of high-purity C2 H4 as an essential raw material in the petrochemical industry. Due to their similar physicochemical properties, the separation of C2 H4 from the C2 hydrocarbons typically entails high-energy separation technologies such as cryogenic distillation and extraction. Alternatively, adsorption separation using metal-organic frameworks (MOFs) are low-energy separation technologies that manufacture high-purity gas under mild conditions. In this review, we summarized the recent advances in MOFs for the separation and purification of C2 H4 from the C2 hydrocarbons. The mechanisms underlying separating C2 H4 from the C2 hydrocarbons using MOFs are also highlighted. This review also discussed the major challenges and developments of MOFs to separate C2 H4 from the C2 hydrocarbons.
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Developing an intelligent theranostic nanoplatform with satisfied diagnostic accuracy and therapeutic efficiency holds great promise for personalized nanomedicine. Herein, we constructed a smart nanodevice for the accurate diagnosis of endogenous cancer microRNA (miRNA) biomarkers and efficient photothermal therapy (PTT). The nanodevice was composed of polydopamine (PDA)-functionalized CuS nanosheets (CuS@PDA NSs) and three elaborate DNA hairpin probes (TDHPs). The CuS@PDA NSs acted as efficient delivery vehicles and photothermal agents. They provided a large surface area available for an efficient and facile loading of TDHPs and a high-fluorescence (FL) quenching performance to achieve an ultralow background signal. The intracellular miRNA triggered TDHPs to assemble into three-arm branched junction structures for a strong fluorescence recovery as output signals to discriminate cancer cells from normal cells with an excellent sensitivity. The CuS@PAD NSs showed a good photothermal conversion efficiency in the near-infrared II (NIR II) region to mediate a good photothermal performance to kill cancer cells. A remarkable antitumor therapeutic effect was achieved in vivo. This work integrated highly sensitive detection to endogenous cancer biomarkers and valid therapeutic potency to tumor-bearing mice, indicating its promising biomedical applications.
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MicroRNAs , Nanopartículas , Neoplasias , Animais , Sondas de DNA , Camundongos , MicroRNAs/genética , Nanopartículas/química , Neoplasias/tratamento farmacológico , Neoplasias/terapia , Fototerapia , Terapia FototérmicaRESUMO
Mitochondrial microRNAs (mitomiRs) critically orchestrate mitochondrial functions. Spatial imaging of mitomiRs is essential to understand its clinical value in diagnosis and prognosis. However, the direct monitoring of mitomiRs in living cells remains a key challenge. Herein, we report an AIE nanoreporter strategy for mitomiRs imaging in living cells through pH-controlled exonuclease (Exo)-assisted target cycle signal amplification. The AIE-labeled DNA detection probes are conjugated on Exo III encapsulated polymeric nanoparticles (NPs) via consecutive adenines (polyA). The amplified sensing functions are off during the cytoplasm delivery process, and it can be spatially switched from off to on when in the alkaline mitochondria (about pH 8) after triphenylphosphonium (TPP)-mediated mitochondrial targeting. Where the NPs degraded to release Exo III and cancer-specific mitomiRs hybridize with AIE-labeled DNA detection probes to expose the cleavage site of released Exo III, enabling spatially restricted mitomiRs imaging. The mitomiRs expression fluctuation was also realized. This study contributes to a facile strategy that could easily extend to a broad application for the understanding of mitomiRs-related pathological processes.
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Técnicas Biossensoriais , MicroRNAs , Técnicas Biossensoriais/métodos , DNA/metabolismo , Sondas de DNA/metabolismo , Exodesoxirribonucleases/metabolismo , Concentração de Íons de Hidrogênio , Limite de Detecção , MicroRNAs/genética , MicroRNAs/metabolismo , Mitocôndrias/metabolismoRESUMO
AIMS: The association between low-to-moderate alcohol consumption and atrial fibrillation (AF) has yet to be fully elucidated. The main purpose of this meta-analysis was to estimate the risk of incident AF related to low-to-moderate alcohol consumption. METHODS AND RESULTS: A meta-analysis was performed on 13 publications discussing the estimated risk for AF with habitual low-to-moderate alcohol intake in 10 266 315 participants. Graphical augmentations to the funnel plots were used to illustrate the potential impact of additional evidence on the current meta-analysis. Thirteen eligible studies were included in this meta-analysis. We found that moderate alcohol consumption was associated with an increased risk of incident AF in males [hazard ratio (HR) 1.09, 95% confidence interval (CI): 1.07-1.11, P < 0.00001], Europeans (HR 1.32, 95% CI: 1.23-1.42, P < 0.00001), and Asians (HR 1.09, 95% CI: 1.07-1.11, P < 0.00001). Moderate beer consumption was associated with an increased risk of developing AF (HR 1.11, 95% CI: 1.02-1.21, P = 0.01). Low alcohol consumption conferred an increased risk of AF in males (HR 1.14, 95% CI: 1.01-1.28, P = 0.04) and Europeans (HR 1.12, 95% CI: 1.07-1.17, P < 0.00001). CONCLUSIONS: This analysis represents the increased risk of incident AF in males, Europeans, and Asians at moderate alcohol consumption levels and in males and Europeans at low alcohol consumption levels. Those who drink any preferred alcohol beverage at moderate levels should be cautious for incident AF. More studies are warranted to find those factors that influence alcohol's effect on predisposing AF.
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Fibrilação Atrial , Consumo de Bebidas Alcoólicas/efeitos adversos , Consumo de Bebidas Alcoólicas/epidemiologia , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/epidemiologia , Fibrilação Atrial/etiologia , Etanol , Humanos , Masculino , Modelos de Riscos Proporcionais , Fatores de RiscoRESUMO
Metal-organic frameworks have been widely studied in the separation of C2 hydrocarbons, which usually preferentially bind unsaturated hydrocarbons with the order of acetylene (C2 H2 )>ethylene (C2 H4 )>ethane (C2 H6 ). Herein, we report an ultramicroporous fluorinated metal-organic framework Zn-FBA (H2 FBA=4,4'-(hexafluoroisopropylidene)bis(benzoic acid)), shows a reversed adsorption order characteristic for C2 hydrocarbons, that the uptake for C2 hydrocarbons of the framework and the binding affinity between the guest molecule and the framework follows the order C2 H6 >C2 H4 >C2 H2 . Density-functional theory calculations confirm that the completely reversed adsorption order behavior is attributed to the close van der Waals interactions and multiple cooperative C-Hâ â â F hydrogen bonds between the framework and C2 H6 . Moreover, Zn-FBA exhibits a high selectivity of about 2.9 for C2 H6 over C2 H4 at 298â K and 1â bar. The experimental breakthrough studies show that the high-purity C2 H4 can be obtained from C2 H6 and C2 H4 mixtures in one step.
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The separation of acetylene and carbon dioxide is an essential but challenging process owing to the similar molecular sizes and physical properties of the two gas molecules. Notably, these molecules usually exhibit different orientations in the pore channel. We report an adsorption site selective occupation strategy by taking advantage of differences in orientation to sieve the C2 H2 from CO2 in a judiciously designed amine-functionalized metal-organic framework, termed CPL-1-NH2 . In this material, the incorporation of amino groups not only occupies the adsorption sites of CO2 molecules and shields the interaction of uncoordinated oxygen atom and CO2 molecules resulting in a negligible adsorption amount and a decrease in enthalpy of adsorption but also strengthened the binding affinity toward C2 H2 molecules. This material thus shows an extremely high amount of C2 H2 at low pressure and a remarkably high C2 H2 /CO2 IAST selectivity (119) at 1â bar and 298â K.
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Natural gas, primarily composed of methane (CH4), represent an excellent choice for a potentially sustainable renewable energy transition. However, the process of compressing and liquefying CH4 for transport and storage typically results in significant energy losses. In addition, in order to optimize its efficacy as a fuel, the CH4 content of natural gas needs to be increased to a level of at least 97% to ensure its quality and efficiency in various applications. Metal-organic frameworks (MOFs) represent a novel category of porous materials that possess exceptional capability in modifying pore size and chemical environment, making them ideally suited for the storage of CH4 and the adsorption of propane (C3H8), ethane (C2H6), carbon dioxide (CO2), nitrogen (N2), and hydrogen sulfide (H2S) to facilitate the purification process of CH4 from natural gas. In this paper, we systematically summarize the mechanism by which MOF materials facilitate the storage of CH4 and the purification of CH4 from natural gas, leveraging the structural characteristics inherent to MOF materials. The focus of further research should also be directed towards the investigation of CH4 storage by flexible MOFs, the resolution of the trade-off dilemma, and the commercial application of MOFs.
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Fluorescently labeled DNA oligonucleotides and gold nanospheres have been frequently utilized in biosensors, providing efficient nucleic acid detection. Nevertheless, the restricted loading capacity of gold nanospheres undermines overall sensitivity. In this study, we employed four-atom-thick ultrathin gold nanosheets (AuNSs), utilizing a "pre-mix model" for rapid target nucleic acid detection. In this approach, fluorescently labeled DNA probes were pre-incubated with the target nucleic acid, followed by the addition of AuNSs for probe adsorption and fluorescence quenching. With the developed method, we efficiently and rapidly detected the SARS-CoV-2 N gene sequence within 30 min, involving a brief 15-min target pre-incubation and a subsequent 15-min adsorption of free probes and fluorescence quenching by AuNSs. This method exhibited heightened sensitivity compared to gold nanospheres, boasting a limit of detection (LOD) of 0.808 nM. Furthermore, exceptional recovery was achieved in simulated biological samples. The study introduces an effective strategy for nucleic acid sensing characterized by rapidity, heightened sensitivity, ease of operation, and robustness. These findings encourage further development of rapid biomarker sensing methods employing 2D nanomaterials.
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Técnicas Biossensoriais , Corantes Fluorescentes , Ouro , Limite de Detecção , Nanopartículas Metálicas , SARS-CoV-2 , Ouro/química , SARS-CoV-2/isolamento & purificação , Corantes Fluorescentes/química , Técnicas Biossensoriais/métodos , Nanopartículas Metálicas/química , Humanos , Espectrometria de Fluorescência , Nanoestruturas/química , Sondas de DNA/química , COVID-19/diagnóstico , COVID-19/virologiaRESUMO
A lipid second messenger, phosphatidylinositol (3,4,5)-trisphosphate (PIP3), is a signaling molecule that mediates central cellular events, such as growth, motility, and development by activating downstream proteins. Although functions of various PIP3 binding partners have been unveiled, the various roles of PIP3 have not been resolved thoroughly because of limitations of PIP3 analysis. Herein, we describe a novel method for the analysis of relative PIP3 amount based on spontaneous complementation of split luciferase fragments. An N-terminal fragment of a luciferase was located on the plasma membrane (LucN-pm). A C-terminal fragment of a luciferase fused with PIP3 binding units, pleckstrin homology domains (PHDs) of the general receptor for phosphoinositides 1 (GRP1), was expressed in cytosol (PP-LucC). In response to PIP3 production, PP-LucC was brought to the plasma membrane and colocalized with LucN-pm. The LucN-pm and PP-LucC reconstituted spontaneously to form an active luciferase, producing bioluminescence recovery. We obtained bioluminescence signals corresponding to relative PIP3 amounts successfully upon stimulation with an agonist. We also demonstrated that the probes were applied for a high-throughput screening format and for monitoring of PIP3 production on the plasma membrane by bioluminescence. This method enables further study of PIP3 and supports versatile applications related to the PIP3 amount.
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Corantes Fluorescentes/química , Luciferases/química , Medições Luminescentes/métodos , Fosfatos de Fosfatidilinositol/análise , Animais , Células CHO , Cricetulus , LigantesRESUMO
Chronic kidney disease (CKD) emerges as a substantial contributor to various cardiovascular disorders, including ischemic cardiomyopathy (ICM). However, the underlying molecular mechanisms linking CKD and ICM remain elusive. Our study aims to unravel these connections by integrating publicly available bulk and single-cell RNA sequencing (scRNA-seq) data. Expression profiles from two ICM datasets obtained from heart tissue and one CKD with Peripheral Blood Mononuclear Cell (CKD-PBMC) dataset were collected. We initiated by identifying shared differentially expressed genes (DEGs) between ICM and CKD. Subsequent functional enrichment analysis shed light on the mechanisms connecting CKD to ICM. Machine learning algorithms enabled the identification of 13 candidate genes, including AGRN, COL16A1, COL1A2, FAP, FRZB, GPX3, ITIH5, NFASC, PTN, SLC38A1, STARD7, THBS2, and VPS35. Their expression patterns in ICM were investigated via scRNA-seq data analysis. Notably, most of them were enriched in fibroblasts. COL16A1, COL1A2, PTN, and FAP were enriched in scar-formation fibroblasts, while GPX3 and THBS2 showed enrichment in angiogenesis fibroblasts. A Gaussian naïve Bayes model was developed for diagnosing CKD-related ICM, bolstered by SHapley Additive exPlanations interpretability and validated internally and externally. In conclusion, our investigation unveils the extracellular matrix's role in CKD and ICM interplay, identifies 13 candidate genes, and showcases their expression patterns in ICM. We also constructed a diagnostic model using 13 gene features and presented an innovative approach for managing CKD-related ICM through serum-based diagnostic strategies.
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This study develops a comprehensive framework for understanding the interaction of shale gas-water-carbon nexus in Sichuan-Chongqing region. Within this framework, a county-level water security index (WSI) evaluation system is structured. Spatial autocorrelation model and spatial matching degree model are integrated to illustrate the spatial agglomeration characteristics of water security and the water-carbon relationship, respectively. The impacts of shale gas development on water security and carbon emissions are evaluated based on identification of shale well productivity. Results show that about 25.17% of counties with WSI < 0.4 (unsafe), especially in the eastern region. The central cities (such as Chengdu and Neijiang) should take active steps to reach a safety threshold (WSI ≥ 0.6). Population growth can accelerate water security deterioration through uncertainty analysis. Moreover, the spatial matching degree between WSI and carbon emissions in most cities is extremely poor (< 0.5), implying that these cities should optimize their energy structure and promote green transformation. Water used for shale gas extraction can hardly be ignored from a county-scale perspective, especially in Tongliang, Tongnan, and Jianyang. The future shale gas development would pose a threat to the regional climate.
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Gás Natural , Água , Gás Natural/análise , Água/análise , Carbono/análise , Clima , Abastecimento de Água , ChinaRESUMO
Vanadium tailings from vanadium extraction by a sodium roasting process are solid waste and cannot be used in sintering and ironmaking due to their high sodium content. In this paper, a calcification and reduction roasting process was proposed to remove sodium from vanadium tailings. The effects of Ca(OH)2 addition, reduction temperature, and roasting time on the sodium removal behavior and compression strength of pellets were studied. The addition of Ca(OH)2 and the reduction of iron oxides promoted the sodium-containing phases to transform to be simpler, which could enhance sodium removal. The sodium removal rate was up to 93.47% and the compression strength of the reduced products was 4497 N/P, and the metallized ratio of the product was higher than 70% under the optimal conditions: roasting at 1200 °C for 2 h with the Ca(OH)2 addition of 35%. The treated product after removing sodium can be recycled in the ironmaking process in a steel company.
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Zinc-containing dust can be found in ironmaking and steelmaking, and it is an important secondary resource of zinc. Zinc-containing dust from an electric furnace was used as a raw material to study the phase transformation behavior of the dust using a calcification roasting process and the zinc-iron separation behavior by using ammonia leaching. The zinc-bearing dust was mixed with CaO and roasted to transform the zinc ferrite into zinc oxide. The results showed that increasing the calcium oxide to dust ratio could promote the conversion of zinc ferrite to zinc oxide. When the calcium oxide ratio reached 60%, the peak of zinc ferrite in the calcined-roasted product in the zinc-containing dust basically disappeared. As the temperature increased, the zinc oxide grains increased but were still smaller than 10 µm. The calcined-roasted product was crushed and ground, and the zinc was leached by ammonia. A zinc-iron recovery rate of 86.12% was achieved by the ammonia leaching. The leachate could be used for zinc extraction by electrolysis. The leaching residue was mainly calcium ferrate, which could be used in sintering production. The proposed process may achieve on-site recovery of zinc-containing dust in steel-making plants.
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COVID-19 is still a global public health concern, and the SARS-CoV-2 mutations require more effective antiviral agents. In this study, the antiviral entry activity of thirty-one flavonoids was systematically evaluated by a SARS-CoV-2 pseudovirus model. Twenty-four flavonoids exhibited antiviral entry activity with IC50 values ranging from 10.27 to 172.63 µM and SI values ranging from 2.33 to 48.69. The structure-activity relationship of these flavonoids as SARS-CoV-2 entry inhibitors was comprehensively summarized. A subsequent biolayer interferometry assay indicated that flavonoids bind to viral spike RBD to block viral interaction with ACE2 receptor, and a molecular docking study also revealed that flavonols could bind to Pocket 3, the non-mutant regions of SARS-CoV-2 variants, suggesting that flavonols might be also active against virus variants. These natural flavonoids showed very low cytotoxic effects on human normal cell lines. Our findings suggested that natural flavonoids might be potential antiviral entry agents against SARS-CoV-2 via inactivating the viral spike. It is hoped that our study will provide some encouraging evidence for the use of natural flavonoids as disinfectants to prevent viral infections.
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COVID-19 , SARS-CoV-2 , Humanos , SARS-CoV-2/metabolismo , Simulação de Acoplamento Molecular , Flavonoides/farmacologia , Antivirais/farmacologia , Flavonóis , Glicoproteína da Espícula de Coronavírus/metabolismo , Ligação ProteicaRESUMO
Idiopathic pulmonary arterial hypertension (IPAH) and chronic thromboembolic pulmonary hypertension (CTEPH) can result in right heart failure. We aimed to evaluate the plasma protein levels of a disintegrin and metalloproteinase with thrombospondin motifs like 4 (ADAMTSL4) and its relationship with IPAH and CTEPH. Plasma ADAMTSL4 protein levels were measured using proteomics analysis in eight patients with IPAH and nine healthy controls. ADAMTSL4 levels in pulmonary tissues were assessed using bioinformatics tools. Protein expression of ADAMTSL4 in platelet-derived growth factor (PDGF)-BB-treated primary rat pulmonary arterial smooth muscle cells (PASMCs) was detected by Western blot. Plasma ADAMTSL4 concentrations were measured in 45 patients (15 with IPAH and 30 with CTEPH) using enzyme-linked immunosorbent assay (ELISA). Correlation between ADAMTSL4 levels and clinical parameters was evaluated. In patients with IPAH, the plasma levels of ADAMTSL4 protein were significantly higher than those in healthy controls (flod change [FC] 1.85, p < 0.05), and mRNA expression levels were significantly elevated (log FC 0.66, p < 0.05). The protein expression of ADAMTSL4 was significantly increased in PDGF-BB-treated PASMCs compared to that in the control grAoup (p < 0.05). Plasma ADAMTSL4 protein levels in patients with IPAH (4.71 ± 0.73 ng/mL, p < 0.01) and CTEPH (4.22 ± 0.66 ng/mL, p < 0.01) were higher than in healthy controls (3.01 ± 0.46 ng/mL). Plasma ADAMATL4 protein levels had a cutoff value of 3.55 ng/mL based on the receiver operator characteristic curve and were positively correlated with mean pulmonary artery pressure (mPAP) (r = 0.305, p < 0.05). In patients with IPAH and CTEPH, elevated plasma ADAMTSL4 levels were positively associated with mPAP.
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Objectives: This study aimed to determine whether SII on different days of admission is associated with severity and 180-day functional outcomes after basal ganglia ICH. Methods: In this retrospective study, data on baseline CT imaging characteristics, mRS, hematoma volume, and laboratory variables were included. The SII and NLR, LMR, and PLR were calculated from laboratory data collected on admission day, day 1, and days 5-7. Both univariate and multivariable logistic regression analyses were used to assess the association between the SII and the outcome. The receiver operating characteristic (ROC) analysis and area under the curve (AUC) were also used to evaluate the ability of the SII to predict outcomes. Result: A total of 245 patients were enrolled in the study. On different days, the NLR, PLR, and SII were significantly lower in patients with favorable outcomes than in those with poor outcomes, and the volume of hemorrhage was positively correlated with the SII. These parameters were associated with outcomes in the univariate logistic regression. In the adjusted analyses, the SII and PLR were independent predictors of basal ganglia ICH outcomes. ROC analysis revealed that the SII showed a stronger ability to predict the 6-month outcomes of patients after basal ganglia ICH than the PLR on different days (AUC = 0.642, 0.804, 0.827 vs. 0.592, 0.725, 0.757; all P < 0.001). Conclusion: The SII independently and strongly predicts the outcome of basal ganglia ICH. A high SII was associated with poor 6-month outcomes in patients with basal ganglia ICH.
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The collection and analysis of biological samples are an effective means of disease diagnosis and treatment. Blood sampling is a traditional approach in biological analysis. However, the blood sampling approach inevitably relies on invasive techniques and is usually performed by a professional. The microneedle (MN)-based devices have gained increasing attention due to their noninvasive manner compared to the traditional blood-based analysis method. In the present review, we introduce the materials for fabrication of MNs. We categorize MN-based devices based on four classes: MNs for transdermal sampling, biomarker capture, detecting or monitoring analytes, and bio-signal recording. Their design strategies and corresponding application are highlighted and discussed in detail. Finally, future perspectives of MN-based devices are discussed.