Detalhe da pesquisa
1.
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa®.
Bioorg Med Chem Lett
; 29(16): 2415-2427, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31230974
2.
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg Med Chem Lett
; 29(16): 2428-2436, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31133531
3.
[Analysis of tobacco style features using near-infrared spectroscopy and projection model].
Guang Pu Xue Yu Guang Pu Fen Xi
; 34(10): 2764-8, 2014 Oct.
Artigo
em Zh
| MEDLINE | ID: mdl-25739222
4.
Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873.
ACS Med Chem Lett
; 15(4): 546-554, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628802
5.
N-linoleyltyrosine resisted the growth of non-small cell lung cancer cells via the regulation of CB1 and CB2 involvement of PI3K and ERK pathways.
Front Pharmacol
; 14: 1164367, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37361232
6.
N-linoleyltyrosine ameliorates high-fat diet-induced obesity in C57BL/6 mice via cannabinoid receptor regulation.
Front Endocrinol (Lausanne)
; 13: 938527, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36111301
7.
N-linoleyltyrosine protects neurons against Aß1-40-induced cell toxicity via autophagy involving the CB2/AMPK/mTOR/ULK1 pathway.
Brain Res Bull
; 188: 203-213, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35934162
8.
In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile.
Antimicrob Agents Chemother
; 55(4): 1366-76, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21245449
9.
Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.
Bioorg Med Chem Lett
; 21(19): 5831-4, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21871800
10.
Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents.
Bioorg Med Chem
; 18(12): 4363-73, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20537902
11.
Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.
Bioorg Med Chem
; 18(20): 7203-11, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20846868
12.
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.
J Mol Biol
; 363(3): 635-47, 2006 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16979654
13.
Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 2033-46, 2014 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24320933
14.
[Influence of La2O3 and Li2O on glass powder for infiltrating ZTA all-ceramic dental material formed by gel-casting].
Shanghai Kou Qiang Yi Xue
; 21(5): 488-94, 2012 Oct.
Artigo
em Zh
| MEDLINE | ID: mdl-23135175
15.
Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents.
Eur J Med Chem
; 49: 74-85, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22265685
16.
Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues.
Eur J Med Chem
; 46(10): 4924-36, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21864952
17.
Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection.
J Med Chem
; 59(16): 7696, 2016 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27529494
18.
Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK.
Bioorg Med Chem Lett
; 17(15): 4316-9, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17533128
19.
Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.
Bioorg Med Chem
; 11(6): 1031-4, 2003 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12614889
20.
Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs.
Bioorg Med Chem Lett
; 14(23): 5855-7, 2004 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15501055