Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Mais filtros

Base de dados
Tipo de documento
Assunto da revista
País de afiliação
Intervalo de ano de publicação
1.
Endoscopy ; 56(5): 334-342, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38412993

RESUMO

BACKGROUND: Inaccurate Forrest classification may significantly affect clinical outcomes, especially in high risk patients. Therefore, this study aimed to develop a real-time deep convolutional neural network (DCNN) system to assess the Forrest classification of peptic ulcer bleeding (PUB). METHODS: A training dataset (3868 endoscopic images) and an internal validation dataset (834 images) were retrospectively collected from the 900th Hospital, Fuzhou, China. In addition, 521 images collected from four other hospitals were used for external validation. Finally, 46 endoscopic videos were prospectively collected to assess the real-time diagnostic performance of the DCNN system, whose diagnostic performance was also prospectively compared with that of three senior and three junior endoscopists. RESULTS: The DCNN system had a satisfactory diagnostic performance in the assessment of Forrest classification, with an accuracy of 91.2% (95%CI 89.5%-92.6%) and a macro-average area under the receiver operating characteristic curve of 0.80 in the validation dataset. Moreover, the DCNN system could judge suspicious regions automatically using Forrest classification in real-time videos, with an accuracy of 92.0% (95%CI 80.8%-97.8%). The DCNN system showed more accurate and stable diagnostic performance than endoscopists in the prospective clinical comparison test. This system helped to slightly improve the diagnostic performance of senior endoscopists and considerably enhance that of junior endoscopists. CONCLUSION: The DCNN system for the assessment of the Forrest classification of PUB showed satisfactory diagnostic performance, which was slightly superior to that of senior endoscopists. It could therefore effectively assist junior endoscopists in making such diagnoses during gastroscopy.


Assuntos
Úlcera Péptica Hemorrágica , Humanos , Úlcera Péptica Hemorrágica/diagnóstico , Úlcera Péptica Hemorrágica/classificação , Estudos Retrospectivos , Masculino , Pessoa de Meia-Idade , Feminino , Inteligência Artificial , Redes Neurais de Computação , Curva ROC , Estudos Prospectivos , Idoso , Gravação em Vídeo , Gastroscopia/métodos , Reprodutibilidade dos Testes , Adulto
2.
Inorg Chem ; 61(18): 6711-6714, 2022 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-35481753

RESUMO

Herein, a new chiral compound with short Ag-Ag distances, namely, ß-Ag4P2S7 (P3121), has been discovered by a solid-state method. Density functional theory (DFT) calculations show that both α and ß phases exhibit suitable band gaps, low reduction potentials, and large visible-light absorption coefficients, as well as excellent band edges for carrier separation, suggesting their promising application in photocatalytic hydrogen production.

3.
J Dig Dis ; 25(3): 191-199, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38697920

RESUMO

OBJECTIVE: To compare the detection rate and diagnostic accuracy of cardia polyps using endoscopy with blue laser imaging (BLI) and white-light imaging (WLI). METHODS: Patients were randomly divided into the BLI group and WLI group according to the endoscopic procedures. BLI followed by WLI was conducted in the BLI group, whereas WLI followed by BLI examination was conducted in the WLI group. The number, size, microstructure, and microvascular patterns of cardia polyps detected were recorded. Biopsy of the polyps was then performed. RESULTS: The detection rate of cardia polyps in the BLI group was higher than that in the WLI group (7.87% vs 4.22%, P = 0.018). The rate of overlooked lesions in the BLI group was lower than in the WLI group (0.64% vs 3.38%, P = 0.003). The diagnostic coincidence rate between magnifying BLI and histopathology was 88.16%. The sensitivity, specificity, positive predictive value and negative predictive value for the diagnosis of neoplastic lesions by magnifying endoscopy with BLI were 90.91%, 87.69%, 55.56%, and 98.28%, respectively. The most remarkable patterns for predicting inflammatory polyps were the prolonged and fine network patterns (sensitivity 71.43%, specificity 93.75%). Small round combined with honeycomb patterns were the most common among fundic gland polyps (sensitivity 80.00%, specificity 98.48%). Neoplastic lesions presented as villous or ridge-like combined with core vascular or unclear pattern for both microvascular and microstructure patterns. CONCLUSION: BLI is more effective than WLI in the detection and diagnosis of cardia polyps, and magnifying endoscopy with BLI may help diagnose such lesions.


Assuntos
Cárdia , Estudos de Viabilidade , Neoplasias Gástricas , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Cárdia/patologia , Cárdia/diagnóstico por imagem , Adulto , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/patologia , Idoso , Pólipos/diagnóstico por imagem , Pólipos/diagnóstico , Gastroscopia/métodos , Sensibilidade e Especificidade , Valor Preditivo dos Testes , Lasers
4.
Chem Commun (Camb) ; 58(55): 7694-7697, 2022 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-35730669

RESUMO

The first NLO-active metal iodate-phosphates, namely, Cd2(IO3)(PO4) and Cd1.62Mg0.38(IO3)(PO4) (1 and 2), with three types of NLO groups, have been reported. 1 and 2 are isostructural and the structure of 1 features a 3D network formed by the Cd4(IO3)8/4(PO4)6/3 groups. 1 and 2 with strong SHG signals of 4 × and 3.5 × KH2PO4 are promising SHG materials in the visible region.

5.
Sci Rep ; 7(1): 15532, 2017 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-29138513

RESUMO

The liver-enriched transcription factor Forkhead Box A2 (FOXA2) has been reported to be involved in bile acid homeostasis and bile duct development. However, the role of FOXA2 in liver fibrogenesis remains undefined. In this study, we found that the abundance of FOXA2 was significantly lower in fibrotic livers of patients and mice treated with CCl4 than in controls. Interestingly, the expression level of FOXA2 decreased in hepatocytes, whereas FOXA2 was elevated in hepatic stellate cells (HSCs) of mouse fibrotic livers. Hepatocyte-specific ablation of FOXA2 in adult mice exacerbated liver fibrosis induced by CCl4. Either lentivirus LV-CMV-FOXA2 mediated FOXA2 overexpression in the liver or adeno-associated virus AAV8-TBG-FOXA2-mediated hepatocyte-specific upregulation of FOXA2 alleviated hepatic fibrosis. Overexpression of FOXA2 in HSCs did not obviously affect hepatic fibrogenesis. Additionally, FOXA2 knockout in hepatocytes resulted in aberrant transcription of metabolic genes. Furthermore, hepatocyte-specific knockout of FOXA2 enhanced endoplasmic reticulum stress (ER stress) and the apoptosis of hepatocytes, whereas FOXA2 overexpression in hepatocytes suppressed ER stress and hepatocyte apoptosis in mouse fibrotic livers. In conclusion, our findings suggested that FOXA2-mediated hepatocyte protection has a therapeutic role in hepatic fibrosis, and thus may be a new, promising anti-fibrotic option for treating chronic liver diseases.


Assuntos
Tetracloreto de Carbono/toxicidade , Células Estreladas do Fígado/metabolismo , Fator 3-beta Nuclear de Hepatócito/metabolismo , Hepatócitos/metabolismo , Cirrose Hepática/induzido quimicamente , Cirrose Hepática/metabolismo , Animais , Apoptose , Modelos Animais de Doenças , Estresse do Retículo Endoplasmático , Regulação da Expressão Gênica , Células Estreladas do Fígado/patologia , Fator 3-beta Nuclear de Hepatócito/genética , Hepatócitos/patologia , Humanos , Camundongos Endogâmicos C57BL , Substâncias Protetoras/metabolismo , Regulação para Cima
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA