Detalhe da pesquisa
1.
Single-cell genomic variation induced by mutational processes in cancer.
Nature
; 612(7938): 106-115, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36289342
2.
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.
Nature
; 518(7539): 422-6, 2015 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25470049
3.
Clonal genotype and population structure inference from single-cell tumor sequencing.
Nat Methods
; 13(7): 573-6, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27183439
4.
The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type.
J Pathol
; 242(3): 371-383, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28444909
5.
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Nature
; 486(7403): 395-9, 2012 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22495314
6.
TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.
Genome Res
; 24(11): 1881-93, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25060187
7.
PyClone: statistical inference of clonal population structure in cancer.
Nat Methods
; 11(4): 396-8, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24633410
8.
Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro.
Hum Mutat
; 37(3): 301-7, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26694085
9.
Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.
PLoS Med
; 13(12): e1002197, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27959929
10.
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.
Blood
; 123(25): 3914-24, 2014 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24802772
11.
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.
Breast Cancer Res
; 17: 4, 2015 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25572802
12.
Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.
Haematologica
; 99(9): 1456-64, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24895338
13.
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Blood
; 117(8): 2451-9, 2011 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190999
14.
Accurate determination of CRISPR-mediated gene fitness in transplantable tumours.
Nat Commun
; 13(1): 4534, 2022 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35927228
15.
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.
Nat Commun
; 13(1): 3607, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35750695
16.
The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.
BMC Genomics
; 12: 209, 2011 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21527035
17.
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.
Blood
; 113(7): 1432-43, 2009 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18854576
18.
Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.
Commun Biol
; 2: 165, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31069274
19.
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.
Mol Cell Biol
; 22(1): 78-93, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11739724
20.
Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer.
Sci Rep
; 7(1): 13467, 2017 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29044127