Detalhe da pesquisa
1.
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma.
Proc Natl Acad Sci U S A
; 116(46): 23264-23273, 2019 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31662475
2.
Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.
Acta Pharmacol Sin
; 42(1): 149-159, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32451413
3.
Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system.
Bioorg Med Chem
; 28(7): 115358, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32081628
4.
Discovery and anti-inflammatory evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3ß (GSK-3ß).
Bioorg Med Chem
; 26(20): 5479-5493, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30293796
5.
Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine.
Bioorg Med Chem Lett
; 27(15): 3511-3515, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28619536
6.
Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors.
Bioorg Med Chem
; 23(18): 6173-84, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26314925
7.
Tetrazole and triazole as bioisosteres of carboxylic acid: discovery of diketo tetrazoles and diketo triazoles as anti-HCV agents.
Bioorg Med Chem Lett
; 23(16): 4528-31, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856047
8.
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3ß inhibitors through virtual screening.
Bioorg Med Chem Lett
; 22(23): 7232-6, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23099099
9.
(E)-3-(8-Benz-yloxy-2,3-dihydro-1,4-benzodioxin-6-yl)-1-[2-hy-droxy-4,6-bis-(meth-oxy-meth-oxy)phen-yl]prop-2-en-1-one.
Acta Crystallogr Sect E Struct Rep Online
; 67(Pt 4): o912-3, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21754185
10.
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.
Eur J Med Chem
; 226: 113887, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34624824
11.
2-(Furan-2-yl)-5-(2-nitro-benz-yl)-2,3-dihydro-1,5-benzothia-zepin-4(5H)-one.
Acta Crystallogr Sect E Struct Rep Online
; 67(Pt 1): o168, 2010 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21522675
12.
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer.
Cell Metab
; 30(6): 1107-1119.e8, 2019 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31607564
13.
Structure-based 3D-QSAR studies on heteroarylpiperazine derivatives as 5-HT3 receptor antagonists.
Eur J Med Chem
; 42(7): 977-84, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17331624
14.
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3ß inhibitors for the treatment of ovarian cancer.
Eur J Med Chem
; 135: 370-381, 2017 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28460311
15.
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer.
Cell Metab
; 33(1): 223, 2021 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33406402
16.
Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3ß (GSK-3ß).
Eur J Med Chem
; 61: 95-103, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23047001
17.
Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.
Eur J Med Chem
; 52: 33-43, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22445328
18.
Structure-based 3D-QSAR studies on thiazoles as 5-HT3 receptor antagonists.
J Mol Model
; 13(1): 121-31, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16953442