Multifunctional iron-apigenin nanocomplex conducting photothermal therapy and triggering augmented immune response for triple negative breast cancer.

Triple negative breast cancer (TNBC) presents a formidable challenge due to its low sensitivity to many chemotherapeutic drugs and a relatively low overall survival rate in clinical practice. Photothermal therapy has recently garnered substantial interest in cancer treatment, owing to its swift therapeutic effectiveness and minimal impact on normal cells. Metal-polyphenol nanostructures have recently garnered significant attention as photothermal transduction agents due to their facile preparation and favorable photothermal properties. In this study, we employed a coordinated approach involving Fe3+ and apigenin, a polyphenol compound, to construct the nanostructure (nFeAPG), with the assistance of ß-CD and DSPE-PEG facilitating the formation of the complex nanostructure. In vitro research demonstrated that the formed nFeAPG could induce cell death by elevating intracellular oxidative stress, inhibiting antioxidative system, and promoting apoptosis and ferroptosis, and near infrared spectrum irradiation further strengthen the therapeutic outcome. In 4T1 tumor bearing mice, nFeAPG could effectively accumulate into tumor site and exhibit commendable control over tumor growth. Futher analysis demonstrated that nFeAPG ameliorated the suppressed immune microenvironment by augmenting the response of DC cells and T cells. This study underscores that nFeAPG encompasses a multifaceted capacity to combat TNBC, holding promise as a compelling therapeutic strategy for TNBC treatment.

Photothermal nanocomposite reactivate "immune-hot" for triple-negative breast cancer treatment via glutamine metabolism reprograming.

Herein, a photothermal nanocomposite PAI@CB839 nanoparticles (NPs) was constructed to perform a heat-immune therapy for triple-negative breast cancer (TNBC). Firstly, a photothermal agent animated IR780 was modified on a mPEG-NH2 using 4,4'-dicarboxylazobenzene as a linker. The synthesized PAI exhibited superior photothermal efficiency of the IR780 even after assembling in water. As a functional carrier, PAI was used to load and deliver the glutaminase inhibitor CB839 to tumor tissue. In the hypoxic environment of tumor cells, the azo bond would break, triggering the release of cargo. Upon irradiation, the outstanding photothermal properties of IR780 resulted in tumor cell damage. This process could promote immunogenic cell death and program tumor to "immune-hot" condition. Concurrently, CB839 strengthened the antitumor immune response by remodulating the immunosuppressive TME through disturbing Glu abnormal metabolism, which further inhibited TNBC growth and metastasis. In conclusion, PAI@CB839 NPs exhibited great antitumor efficiency, which pave a new way for TNBC therapeutic regimen development.

Enhancement in Electrical and Thermal Properties of LDPE with Al2O3 and h-BN as Nanofiller.

Low-density polyethylene (LDPE) has excellent dielectric properties and is extensively used in electrical equipment. Hexagonal boron nitride (h-BN) is similar to a graphite-layered structure, and alumina fiber (Al2O3) has high-temperature resistance and a strong performance. Herein, we prepared Al2O3-h-BN/LDPE nanocomposites by using LDPE as the matrix material and h-BN and Al2O3 as the fillers. The influence of different doping contents and the mass ratio of Al2O3 and h-BN (1:1) to LDPE on the electrical properties and thermal conductivity of the nanocomposites was examined. The results showed that the suppression effect on space charge was the most obvious and average. The charge density was the lowest and had the minimum decay rate when the doping content was 2%. The breakdown strength of the film reached the maximum value of 340.1 kV/mm, which was 12.3% higher than that of the pure LDPE (302.8 kV/mm). The thermal diffusivity of the composite sample was also higher than that of the single h-BN-doped sample when the content of h-BN and Al2O3 was 7%. The thermal conductivity was 59.3% higher than that of the pure LDPE sample and 20% higher than that of h-BN/LDPE.