Detalhe da pesquisa
1.
Evaluation of the pharmacokinetics of pemigatinib in patients with impaired hepatic or renal function.
Br J Clin Pharmacol
; 88(1): 237-247, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34169560
2.
Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11ß-HSD1.
Bioorg Med Chem Lett
; 73: 128884, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35835377
3.
Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11ß-HSD1 using a scaffold-hopping approach.
Bioorg Med Chem Lett
; 69: 128782, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35537608
4.
Evaluation of drug-drug interactions of pemigatinib in healthy participants.
Eur J Clin Pharmacol
; 77(12): 1887-1897, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34282472
5.
Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment.
Clin Immunol
; 218: 108517, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32585295
6.
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
J Pharmacol Exp Ther
; 374(1): 211-222, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32345620
7.
Effects of Epacadostat on Brain Extracellular Fluid Concentrations of Serotonin-an Intracerebral Microdialysis Study in Sprague-Dawley Rats.
Drug Metab Dispos
; 47(7): 710-714, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31010933
8.
INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies.
J Pharmacol Exp Ther
; 364(1): 120-130, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29127109
9.
Sustained-release ruxolitinib: Findings from a phase 1 study in healthy subjects and a phase 2 study in patients with myelofibrosis.
Hematol Oncol
; 36(4): 701-708, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30105794
10.
In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions.
Drug Metab Dispos
; 45(6): 612-623, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283500
11.
Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans.
Drug Metab Dispos
; 44(10): 1668-74, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27457784
12.
Correction to: Evaluation of drugdrug interactions of pemigatinib in healthy participants.
Eur J Clin Pharmacol
; 77(12): 1899, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34436632
13.
Impact on creatinine renal clearance by the interplay of multiple renal transporters: a case study with INCB039110.
Drug Metab Dispos
; 43(4): 485-9, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25605813
14.
The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Drug Metab Dispos
; 42(10): 1656-62, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25063672
15.
Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J Med Chem
; 67(4): 3112-3126, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325398
16.
Itacitinib Population Pharmacokinetics and Exposure-Response in Patients With Acute Graft-Versus-Host Disease.
J Clin Pharmacol
; 63(5): 622-632, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36601737
17.
Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors.
ACS Med Chem Lett
; 14(1): 5-10, 2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36655125
18.
Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
ACS Med Chem Lett
; 14(1): 116-122, 2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36655134
19.
Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis.
J Am Acad Dermatol
; 67(4): 658-64, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22281165
20.
Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050.
J Immunol
; 184(9): 5298-307, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20363976