Detalhe da pesquisa
1.
Structural basis for the recognition of α-1,6-branched α-glucan by GH13_47 α-amylase from Rhodothermus marinus.
Proteins
; 2024 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641972
2.
Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Cell Rep
; 42(2): 111940, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719796
3.
Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.
J Antimicrob Chemother
; 63(3): 469-72, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176591
4.
Protein geranylgeranyltransferase-I of Trypanosoma cruzi.
Mol Biochem Parasitol
; 157(1): 32-43, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17996962
5.
2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials.
Bioorg Med Chem Lett
; 18(2): 494-7, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077162
6.
C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins.
Mol Biochem Parasitol
; 153(2): 115-24, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17397944
7.
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Mol Biochem Parasitol
; 152(1): 66-71, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17208314
8.
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
J Med Chem
; 50(19): 4585-605, 2007 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17722901
9.
PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.
Nat Commun
; 8: 14609, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28248300
10.
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
J Med Chem
; 49(19): 5710-27, 2006 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16970397
11.
Genome sequence and analysis of the Japanese morning glory Ipomoea nil.
Nat Commun
; 7: 13295, 2016 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27824041
12.
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
J Med Chem
; 48(11): 3704-13, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15916422
13.
Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation.
Biochem Pharmacol
; 70(12): 1735-43, 2005 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16257390
14.
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
Curr Opin Investig Drugs
; 6(8): 791-7, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16121685
15.
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.
Mol Biochem Parasitol
; 126(2): 155-63, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12615314
16.
Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major.
Mol Biochem Parasitol
; 122(2): 181-8, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12106872
17.
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
J Med Chem
; 47(2): 432-45, 2004 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14711313
18.
Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.
Br J Pharmacol
; 138(5): 811-8, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12642382
19.
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angew Chem Int Ed Engl
; 44(31): 4903-6, 2005 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16007716
20.
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Antimicrob Agents Chemother
; 51(10): 3659-71, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17606674