Detalhe da pesquisa
1.
Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
Nucleic Acids Res
; 51(1): 475-487, 2023 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36546776
2.
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.
Nucleic Acids Res
; 50(3): 1484-1500, 2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35037045
3.
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Nucleic Acids Res
; 49(16): 9294-9309, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387694
4.
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Nucleic Acids Res
; 49(16): 9310-9326, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387696
5.
Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.
J Biol Chem
; 291(38): 19873-87, 2016 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27474741
6.
Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.
Angew Chem Int Ed Engl
; 55(28): 7930-3, 2016 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145301
7.
Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.
J Struct Biol
; 192(3): 539-544, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522274
8.
The 1.65â Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 3): 525-33, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25760602
9.
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.
Chem Sci
; 15(21): 8227-8241, 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38817593
10.
Structure of AKR1C3 with 3-phenoxybenzoic acid bound.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 4): 409-13, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505408
11.
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Nat Commun
; 12(1): 4848, 2021 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34381037
12.
The SNM1A DNA repair nuclease.
DNA Repair (Amst)
; 95: 102941, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866775
13.
TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptorâ 1 (FGFR1) Irreversible Structure.
ChemMedChem
; 14(4): 494-500, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30600916
14.
Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.
ACS Med Chem Lett
; 10(8): 1180-1186, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413803
15.
2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.
Eur J Med Chem
; 135: 531-543, 2017 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28521156
16.
Structures of Human Peroxiredoxin 3 Suggest Self-Chaperoning Assembly that Maintains Catalytic State.
Structure
; 24(7): 1120-9, 2016 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27238969
17.
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
PLoS One
; 7(8): e43965, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22937138
18.
The interaction of human neuroglobin with hydrogen sulphide.
IUBMB Life
; 60(2): 135-8, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18380003