Detalhe da pesquisa
1.
Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction.
Bioorg Med Chem Lett
; 64: 128664, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35272008
2.
Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond.
Bioorg Med Chem Lett
; 33: 127742, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33316407
3.
Discovery of novel integrase-LEDGF/p75 allosteric inhibitors based on a benzene scaffold.
Bioorg Med Chem
; 28(17): 115643, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32773094
4.
Barrier to Resistance of Dolutegravir in Two-Drug Combinations.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30602514
5.
Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis.
PLoS Pathog
; 13(7): e1006441, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28683086
6.
Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease.
Bioorg Med Chem Lett
; 26(19): 4739-4742, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27568084
7.
Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.
Antimicrob Agents Chemother
; 59(1): 397-406, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25367908
8.
Effects of raltegravir or elvitegravir resistance signature mutations on the barrier to dolutegravir resistance in vitro.
Antimicrob Agents Chemother
; 59(5): 2596-606, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25691633
9.
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
Antimicrob Agents Chemother
; 55(2): 813-21, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21115794
10.
Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease.
J Med Chem
; 62(17): 8101-8114, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31386363
11.
Novel secondary mutations C56S and G149A confer resistance to HIV-1 integrase strand transfer inhibitors.
Antiviral Res
; 152: 1-9, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29410019
12.
In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
Antiviral Res
; 160: 109-117, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30316915
13.
Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae.
Antiviral Res
; 117: 52-9, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25752738
14.
Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics.
PLoS One
; 8(10): e77448, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24146996
15.
Carbamoyl pyridone HIV-1 integrase inhibitors. 2. Bi- and tricyclic derivatives result in superior antiviral and pharmacokinetic profiles.
J Med Chem
; 56(3): 1124-35, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23316884
16.
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
J Med Chem
; 56(14): 5901-16, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845180
17.
Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore.
J Med Chem
; 55(20): 8735-44, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22963135
18.
A strategy for neuraminidase inhibitors using mechanism-based labeling information.
Chem Asian J
; 6(4): 1048-56, 2011 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21305698
19.
Secondary mutations in viruses resistant to HIV-1 integrase inhibitors that restore viral infectivity and replication kinetics.
Antiviral Res
; 81(2): 141-6, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19027039
20.
Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
J Med Chem
; 52(9): 2754-61, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19374386