Detalhe da pesquisa
1.
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis.
EMBO J
; 40(23): e103718, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34698396
2.
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase.
Biochem J
; 480(9): 665-684, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37115711
3.
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.
Proc Natl Acad Sci U S A
; 117(15): 8468-8475, 2020 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234780
4.
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Immunity
; 39(3): 443-53, 2013 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012422
5.
SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.
Biochem J
; 478(13): 2555-2569, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34109974
6.
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs.
Biochem J
; 478(17): 3351-3371, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34431498
7.
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity.
Immunity
; 36(2): 239-50, 2012 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342841
8.
The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.
Biochem J
; 473(12): 1733-44, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27059856
9.
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Proc Natl Acad Sci U S A
; 111(42): 15072-7, 2014 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288762
10.
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.
Biochem J
; 471(2): 255-65, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26283547
11.
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
Biochem J
; 457(3): 369-77, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24219132
12.
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
Biochem J
; 458(2): 395-405, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24354892
13.
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Biochem J
; 457(2): 323-34, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24107129
14.
Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.
Growth Factors
; 32(1): 18-26, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24438083
15.
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion.
Commun Biol
; 7(1): 461, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38627519
16.
An immunohistochemical atlas of necroptotic pathway expression.
EMBO Mol Med
; 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38750308
17.
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Nat Commun
; 14(1): 6804, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884510
18.
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
Nat Commun
; 14(1): 6046, 2023 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37770424
19.
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling.
Cell Death Dis
; 13(6): 565, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35739084
20.
A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes.
Cell Death Dis
; 12(4): 345, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33795639