Detalhe da pesquisa
1.
An entropy weight method to integrate big omics and mechanistically evaluate DILI.
Hepatology
; 2023 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37820269
2.
Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation.
Ecotoxicol Environ Saf
; 277: 116330, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38636406
3.
miR-145a-5p/SIK1/cAMP-dependent alteration of synaptic structural plasticity drives cognitive impairment induced by coke oven emissions.
Ecotoxicol Environ Saf
; 277: 116401, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38677069
4.
Genomic Characterization Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B.
Environ Sci Technol
; 57(17): 6854-6864, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37071573
5.
Carbon dots induce pathological damage to the intestine via causing intestinal flora dysbiosis and intestinal inflammation.
J Nanobiotechnology
; 21(1): 167, 2023 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37231475
6.
Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes.
Ecotoxicol Environ Saf
; 249: 114361, 2023 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36508832
7.
MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1.
Ecotoxicol Environ Saf
; 261: 115103, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37285672
8.
Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis.
Hepatology
; 73(4): 1551-1569, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32654205
9.
The path via pathway-based approaches towards safety assessment: A concise review.
Toxicol Appl Pharmacol
; 452: 116195, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35977605
10.
Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure.
Part Fibre Toxicol
; 19(1): 42, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35739565
11.
GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation.
Ecotoxicol Environ Saf
; 232: 113248, 2022 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35093813
12.
A toxicity pathway-based approach for modeling the mode of action framework of lead-induced neurotoxicity.
Environ Res
; 199: 111328, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34004169
13.
Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532-3p/Acyl-CoA oxidase 1(ACOX1) pathway.
Ecotoxicol Environ Saf
; 228: 113011, 2021 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34837870
14.
MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway.
Mol Pharmacol
; 98(2): 120-129, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32499331
15.
Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells.
Drug Metab Dispos
; 48(4): 297-306, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32086297
16.
Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure.
Part Fibre Toxicol
; 17(1): 22, 2020 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503629
17.
Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells.
Arch Toxicol
; 94(5): 1637-1653, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32222775
18.
Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity.
Ecotoxicol Environ Saf
; 205: 111166, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32827966
19.
Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk.
Am J Hum Genet
; 99(2): 275-86, 2016 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27453575
20.
Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 37(3): 180-214, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31305208