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1.
J Org Chem ; 81(19): 8759-8769, 2016 10 07.
Artigo em Inglês | MEDLINE | ID: mdl-27560114

RESUMO

Direct unequal C-H bond difunctionalization of phosphorylated diamantane was achieved in high yield from the corresponding phosphonates. Reduction of the functionalized phosphonates provides access to novel primary and secondary alkyl/aryl diamantane phosphines. The prepared primary diamantyl phosphines are quite air stable compared to their adamantyl and especially alkyl or aryl analogues. This finding is corroborated by comparing the singly occupied molecular orbital energy levels of the corresponding phosphine radical cations obtained by density functional theory computations.

2.
J Org Chem ; 79(11): 5369-73, 2014 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-24816428

RESUMO

We present an effective sequence for the preparation of phosphonic acid derivatives of the diamondoids diamantane, triamantane, [121]tetramantane, and [1(2,3)4]pentamantane. The reactions of the corresponding diamondoid hydroxy derivatives with PCl3 in sulfuric or trifluoroacetic acid give mono- as well as didichlorophosphorylated diamondoids in high preparative yields.

3.
Langmuir ; 29(31): 9790-7, 2013 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-23855923

RESUMO

Diamondoids (nanometer-sized diamond-like hydrocarbons) are a novel class of carbon nanomaterials that exhibit negative electron affinity (NEA) and strong electron-phonon scattering. Surface-bound diamondoid monolayers exhibit monochromatic photoemission, a unique property that makes them ideal electron sources for electron-beam lithography and high-resolution electron microscopy. However, these applications are limited by the stability of the chemical bonding of diamondoids on surfaces. Here we demonstrate the stable covalent attachment of diamantane phosphonic dichloride on tungsten/tungsten oxide surfaces. X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared (FTIR) spectroscopy revealed that diamondoid-functionalized tungsten oxide films were stable up to 300-350 °C, a substantial improvement over conventional diamondoid thiolate monolayers on gold, which dissociate at 100-200 °C. Extreme ultraviolet (EUV) light stimulated photoemission from these diamondoid phosphonate monolayers exhibited a characteristic monochromatic NEA peak with 0.2 eV full width at half-maximum (fwhm) at room temperature, showing that the unique monochromatization property of diamondoids remained intact after attachment. Our results demonstrate that phosphonic dichloride functionality is a promising approach for forming stable diamondoid monolayers for elevated temperature and high-current applications such as electron emission and coatings in micro/nano electromechanical systems (MEMS/NEMS).


Assuntos
Cloretos/química , Óxidos/química , Ácidos Fosforosos/química , Tungstênio/química , Tamanho da Partícula , Propriedades de Superfície
4.
Org Lett ; 9(21): 4379-82, 2007 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-17887769

RESUMO

The antimalarial drug FR900098 was prepared from diethyl allylphosphonate involving the nitroso-ene reaction with nitrosocarbonyl methane as the key step followed by hydrogenation and dealkylation. The utilization of dibenzyl allylphosphonate as the starting compound allows one-step hydrogenation with dealkylation, which simplifies the preparative scheme further.


Assuntos
Antimaláricos/síntese química , Fosfomicina/análogos & derivados , Compostos Nitrosos/química , Organofosfonatos/química , Antimaláricos/química , Antimaláricos/farmacologia , Fosfomicina/síntese química , Fosfomicina/química , Fosfomicina/farmacologia , Hidrogenação , Estrutura Molecular , Relação Estrutura-Atividade
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