Developing a Chatbot to Support Individuals With Neurodevelopmental Disorders: Tutorial.

Families of individuals with neurodevelopmental disabilities or differences (NDDs) often struggle to find reliable health information on the web. NDDs encompass various conditions affecting up to 14% of children in high-income countries, and most individuals present with complex phenotypes and related conditions. It is challenging for their families to develop literacy solely by searching information on the internet. While in-person coaching can enhance care, it is only available to a minority of those with NDDs. Chatbots, or computer programs that simulate conversation, have emerged in the commercial sector as useful tools for answering questions, but their use in health care remains limited. To address this challenge, the researchers developed a chatbot named CAMI (Coaching Assistant for Medical/Health Information) that can provide information about trusted resources covering core knowledge and services relevant to families of individuals with NDDs. The chatbot was developed, in collaboration with individuals with lived experience, to provide information about trusted resources covering core knowledge and services that may be of interest. The developers used the Django framework (Django Software Foundation) for the development and used a knowledge graph to depict the key entities in NDDs and their relationships to allow the chatbot to suggest web resources that may be related to the user queries. To identify NDD domain-specific entities from user input, a combination of standard sources (the Unified Medical Language System) and other entities were used which were identified by health professionals as well as collaborators. Although most entities were identified in the text, some were not captured in the system and therefore went undetected. Nonetheless, the chatbot was able to provide resources addressing most user queries related to NDDs. The researchers found that enriching the vocabulary with synonyms and lay language terms for specific subdomains enhanced entity detection. By using a data set of numerous individuals with NDDs, the researchers developed a knowledge graph that established meaningful connections between entities, allowing the chatbot to present related symptoms, diagnoses, and resources. To the researchers' knowledge, CAMI is the first chatbot to provide resources related to NDDs. Our work highlighted the importance of engaging end users to supplement standard generic ontologies to named entities for language recognition. It also demonstrates that complex medical and health-related information can be integrated using knowledge graphs and leveraging existing large datasets. This has multiple implications: generalizability to other health domains as well as reducing the need for experts and optimizing their input while keeping health care professionals in the loop. The researchers' work also shows how health and computer science domains need to collaborate to achieve the granularity needed to make chatbots truly useful and impactful.

Developing a triage predictive model for access to a spinal surgeon using clinical variables and natural language processing of radiology reports.

PURPOSE: To utilize natural language processing (NLP) of MRI reports and various clinical variables to develop a preliminary model predictive of the need for surgery in patients with low back and neck pain. Such a model would be beneficial for informing clinical practice decisions and help reduce the number of unnecessary surgical referrals, streamlining the surgical process. METHODS: A historical cohort study was conducted using de-identified data from patients referred to a spine assessment clinic. Various demographic, clinical, and radiological variables were included as potential predictors. Full-text radiology reports of patients' MRI findings were vectorized using NLP before applying machine learning algorithms to develop models predicting who underwent surgery. Outputs from these models were then entered into a logistic regression model with clinical variables to develop a preliminary model predictive of surgical recommendations. RESULTS: Of the 398 patients assessed, 71 underwent spine surgery. NLP variables were significant predictors in univariate analysis but did not remain in the final logistic regression model. An outcome of receiving surgery was predicted by a primary symptom of low back and leg pain (adjusted odds ratio 2.81), distal pain indicated by a pain diagram (adjusted odds ratio 2.49) and self-reported difficulties walking (adjusted odds ratio 2.73). CONCLUSION: A logistic regression model was created to predict which patients may require spine surgery. Simple clinical variables appeared more predictive than variables created using NLP. However, additional research with more data samples is needed to validate this model and fully evaluate the usefulness of NLP for this task.

Machine Learning for Work Disability Prevention: Introduction to the Special Series.

Rapid development in computer technology has led to sophisticated methods of analyzing large datasets with the aim of improving human decision making. Artificial Intelligence and Machine Learning (ML) approaches hold tremendous potential for solving complex real-world problems such as those faced by stakeholders attempting to prevent work disability. These techniques are especially appealing in work disability contexts that collect large amounts of data such as workers' compensation settings, insurance companies, large corporations, and health care organizations, among others. However, the approaches require thorough evaluation to determine if they add value to traditional statistical approaches. In this special series of articles, we examine the role and value of ML in the field of work disability prevention and occupational rehabilitation.

Validity of the Work Assessment Triage Tool for Selecting Rehabilitation Interventions for Workers' Compensation Claimants with Musculoskeletal Conditions.

Purpose The Work Assessment Triage Tool (WATT) is a clinical decision support tool developed using machine learning to help select interventions for patients with musculoskeletal disorders. The WATT categorizes patients based on individual characteristics according to likelihood of successful return to work following rehabilitation. A previous validation showed acceptable classification accuracy, but we re-examined accuracy using a new dataset drawn from the same system 2 years later. Methods A population-based cohort design was used, with data extracted from a Canadian compensation database on workers considered for rehabilitation between January 2013 and December 2016. Data were obtained on demographic, clinical, and occupational characteristics, type of rehabilitation undertaken, and return to work outcomes. Analysis included classification accuracy statistics of WATT recommendations. Results The sample included 28,919 workers (mean age 43.9 years, median duration 56 days), of whom 23,124 experienced a positive outcome within 30 days following return to work assessment. Sensitivity of the WATT for selecting successful programs was 0.13 while specificity was 0.87. Overall accuracy was 0.60 while human recommendations were higher at 0.72. Conclusions Overall accuracy of the WATT for selecting successful rehabilitation programs declined in a more recent cohort and proved less accurate than human clinical recommendations. Algorithm revision and further validation is needed.

The index lift in data mining has a close relationship with the association measure relative risk in epidemiological studies.

BACKGROUND: Data mining tools have been increasingly used in health research, with the promise of accelerating discoveries. Lift is a standard association metric in the data mining community. However, health researchers struggle with the interpretation of lift. As a result, dissemination of data mining results can be met with hesitation. The relative risk and odds ratio are standard association measures in the health domain, due to their straightforward interpretation and comparability across populations. We aimed to investigate the lift-relative risk and the lift-odds ratio relationships, and provide tools to convert lift to the relative risk and odds ratio. METHODS: We derived equations linking lift-relative risk and lift-odds ratio. We discussed how lift, relative risk, and odds ratio behave numerically with varying association strengths and exposure prevalence levels. The lift-relative risk relationship was further illustrated using a high-dimensional dataset which examines the association of exposure to airborne pollutants and adverse birth outcomes. We conducted spatial association rule mining using the Kingfisher algorithm, which identified association rules using its built-in lift metric. We directly estimated relative risks and odds ratios from 2 by 2 tables for each identified rule. These values were compared to the corresponding lift values, and relative risks and odds ratios were computed using the derived equations. RESULTS: As the exposure-outcome association strengthens, the odds ratio and relative risk move away from 1 faster numerically than lift, i.e. |log (odds ratio)| ≥ |log (relative risk)| ≥ |log (lift)|. In addition, lift is bounded by the smaller of the inverse probability of outcome or exposure, i.e. lift≤ min (1/P(O), 1/P(E)). Unlike the relative risk and odds ratio, lift depends on the exposure prevalence for fixed outcomes. For example, when an exposure A and a less prevalent exposure B have the same relative risk for an outcome, exposure A has a lower lift than B. CONCLUSIONS: Lift, relative risk, and odds ratio are positively correlated and share the same null value. However, lift depends on the exposure prevalence, and thus is not straightforward to interpret or to use to compare association strength. Tools are provided to obtain the relative risk and odds ratio from lift.

A systematic review of data mining and machine learning for air pollution epidemiology.

BACKGROUND: Data measuring airborne pollutants, public health and environmental factors are increasingly being stored and merged. These big datasets offer great potential, but also challenge traditional epidemiological methods. This has motivated the exploration of alternative methods to make predictions, find patterns and extract information. To this end, data mining and machine learning algorithms are increasingly being applied to air pollution epidemiology. METHODS: We conducted a systematic literature review on the application of data mining and machine learning methods in air pollution epidemiology. We carried out our search process in PubMed, the MEDLINE database and Google Scholar. Research articles applying data mining and machine learning methods to air pollution epidemiology were queried and reviewed. RESULTS: Our search queries resulted in 400 research articles. Our fine-grained analysis employed our inclusion/exclusion criteria to reduce the results to 47 articles, which we separate into three primary areas of interest: 1) source apportionment; 2) forecasting/prediction of air pollution/quality or exposure; and 3) generating hypotheses. Early applications had a preference for artificial neural networks. In more recent work, decision trees, support vector machines, k-means clustering and the APRIORI algorithm have been widely applied. Our survey shows that the majority of the research has been conducted in Europe, China and the USA, and that data mining is becoming an increasingly common tool in environmental health. For potential new directions, we have identified that deep learning and geo-spacial pattern mining are two burgeoning areas of data mining that have good potential for future applications in air pollution epidemiology. CONCLUSIONS: We carried out a systematic review identifying the current trends, challenges and new directions to explore in the application of data mining methods to air pollution epidemiology. This work shows that data mining is increasingly being applied in air pollution epidemiology. The potential to support air pollution epidemiology continues to grow with advancements in data mining related to temporal and geo-spacial mining, and deep learning. This is further supported by new sensors and storage mediums that enable larger, better quality data. This suggests that many more fruitful applications can be expected in the future.

Uncovering Flat and Hierarchical Topics by Community Discovery on Word Co-occurrence Network.

Topic modeling aims to discover latent themes in collections of text documents. It has various applications across fields such as sociology, opinion analysis, and media studies. In such areas, it is essential to have easily interpretable, diverse, and coherent topics. An efficient topic modeling technique should accurately identify flat and hierarchical topics, especially useful in disciplines where topics can be logically arranged into a tree format. In this paper, we propose Community Topic, a novel algorithm that exploits word co-occurrence networks to mine communities and produces topics. We also evaluate the proposed approach using several metrics and compare it with usual baselines, confirming its good performances. Community Topic enables quick identification of flat topics and topic hierarchy, facilitating the on-demand exploration of sub- and super-topics. It also obtains good results on datasets in different languages.

General value functions for fault detection in multivariate time series data.

One of the greatest challenges to the automated production of goods is equipment malfunction. Ideally, machines should be able to automatically predict and detect operational faults in order to minimize downtime and plan for timely maintenance. While traditional condition-based maintenance (CBM) involves costly sensor additions and engineering, machine learning approaches offer the potential to learn from already existing sensors. Implementations of data-driven CBM typically use supervised and semi-supervised learning to classify faults. In addition to a large collection of operation data, records of faulty operation are also necessary, which are often costly to obtain. Instead of classifying faults, we use an approach to detect abnormal behaviour within the machine's operation. This approach is analogous to semi-supervised anomaly detection in machine learning (ML), with important distinctions in experimental design and evaluation specific to the problem of industrial fault detection. We present a novel method of machine fault detection using temporal-difference learning and General Value Functions (GVFs). Using GVFs, we form a predictive model of sensor data to detect faulty behaviour. As sensor data from machines is not i.i.d. but closer to Markovian sampling, temporal-difference learning methods should be well suited for this data. We compare our GVF outlier detection (GVFOD) algorithm to a broad selection of multivariate and temporal outlier detection methods, using datasets collected from a tabletop robot emulating the movement of an industrial actuator. We find that not only does GVFOD achieve the same recall score as other multivariate OD algorithms, it attains significantly higher precision. Furthermore, GVFOD has intuitive hyperparameters which can be selected based upon expert knowledge of the application. Together, these findings allow for a more reliable detection of abnormal machine behaviour to allow ideal timing of maintenance; saving resources, time and cost.

Label correlation guided discriminative label feature learning for multi-label chest image classification.

BACKGROUND AND OBJECTIVE: Multi-label Chest X-ray (CXR) images often contain rich label relationship information, which is beneficial to improve classification performance. However, because of the intricate relationships among labels, most existing works fail to effectively learn and make full use of the label correlations, resulting in limited classification performance. In this study, we propose a multi-label learning framework that learns and leverages the label correlations to improve multi-label CXR image classification. METHODS: In this paper, we capture the global label correlations through the self-attention mechanism. Meanwhile, to better utilize label correlations for guiding feature learning, we decompose the image-level features into label-level features. Furthermore, we enhance label-level feature learning in an end-to-end manner by a consistency constraint between global and local label correlations, and a label correlation guided multi-label supervised contrastive loss. RESULTS: To demonstrate the superior performance of our proposed approach, we conduct three times 5-fold cross-validation experiments on the CheXpert dataset. Our approach obtains an average F1 score of 44.6% and an AUC of 76.5%, achieving a 7.7% and 1.3% improvement compared to the state-of-the-art results. CONCLUSION: More accurate label correlations and full utilization of the learned label correlations help learn more discriminative label-level features. Experimental results demonstrate that our approach achieves exceptionally competitive performance compared to the state-of-the-art algorithms.

BrainDAS: Structure-aware domain adaptation network for multi-site brain network analysis.

In the medical field, datasets are mostly integrated across sites due to difficult data acquisition and insufficient data at a single site. The domain shift problem caused by the heterogeneous distribution among multi-site data makes autism spectrum disorder (ASD) hard to identify. Recently, domain adaptation has received considerable attention as a promising solution. However, domain adaptation on graph data like brain networks has not been fully studied. It faces two major challenges: (1) complex graph structure; and (2) multiple source domains. To overcome the issues, we propose an end-to-end structure-aware domain adaptation framework for brain network analysis (BrainDAS) using resting-state functional magnetic resonance imaging (rs-fMRI). The proposed approach contains two stages: supervision-guided multi-site graph domain adaptation with dynamic kernel generation and graph classification with attention-based graph pooling. We evaluate our BrainDAS on a public dataset provided by Autism Brain Imaging Data Exchange (ABIDE) which includes 871 subjects from 17 different sites, surpassing state-of-the-art algorithms in several different evaluation settings. Furthermore, our promising results demonstrate the interpretability and generalization of the proposed method. Our code is available at https://github.com/songruoxian/BrainDAS.

A Collaborative Self-supervised Domain Adaptation for Low-Quality Medical Image Enhancement.

Medical image analysis techniques have been employed in diagnosing and screening clinical diseases. However, both poor medical image quality and illumination style inconsistency increase uncertainty in clinical decision-making, potentially resulting in clinician misdiagnosis. The majority of current image enhancement methods primarily concentrate on enhancing medical image quality by leveraging high-quality reference images, which are challenging to collect in clinical applications. In this study, we address image quality enhancement within a fully self-supervised learning setting, wherein neither high-quality images nor paired images are required. To achieve this goal, we investigate the potential of self-supervised learning combined with domain adaptation to enhance the quality of medical images without the guidance of high-quality medical images. We design a Domain Adaptation Self-supervised Quality Enhancement framework, called DASQE. More specifically, we establish multiple domains at the patch level through a designed rule-based quality assessment scheme and style clustering. To achieve image quality enhancement and maintain style consistency, we formulate the image quality enhancement as a collaborative self-supervised domain adaptation task for disentangling the low-quality factors, medical image content, and illumination style characteristics by exploring intrinsic supervision in the low-quality medical images. Finally, we perform extensive experiments on six benchmark datasets of medical images, and the experimental results demonstrate that DASQE attains state-of-the-art performance. Furthermore, we explore the impact of the proposed method on various clinical tasks, such as retinal fundus vessel/lesion segmentation, nerve fiber segmentation, polyp segmentation, skin lesion segmentation, and disease classification. The results demonstrate that DASQE is advantageous for diverse downstream image analysis tasks.

Development of a computer-based clinical decision support tool for selecting appropriate rehabilitation interventions for injured workers.

PURPOSE: To develop a classification algorithm and accompanying computer-based clinical decision support tool to help categorize injured workers toward optimal rehabilitation interventions based on unique worker characteristics. METHODS: Population-based historical cohort design. Data were extracted from a Canadian provincial workers' compensation database on all claimants undergoing work assessment between December 2009 and January 2011. Data were available on: (1) numerous personal, clinical, occupational, and social variables; (2) type of rehabilitation undertaken; and (3) outcomes following rehabilitation (receiving time loss benefits or undergoing repeat programs). Machine learning, concerned with the design of algorithms to discriminate between classes based on empirical data, was the foundation of our approach to build a classification system with multiple independent and dependent variables. RESULTS: The population included 8,611 unique claimants. Subjects were predominantly employed (85 %) males (64 %) with diagnoses of sprain/strain (44 %). Baseline clinician classification accuracy was high (ROC = 0.86) for selecting programs that lead to successful return-to-work. Classification performance for machine learning techniques outperformed the clinician baseline classification (ROC = 0.94). The final classifiers were multifactorial and included the variables: injury duration, occupation, job attachment status, work status, modified work availability, pain intensity rating, self-rated occupational disability, and 9 items from the SF-36 Health Survey. CONCLUSIONS: The use of machine learning classification techniques appears to have resulted in classification performance better than clinician decision-making. The final algorithm has been integrated into a computer-based clinical decision support tool that requires additional validation in a clinical sample.

WS-LungNet: A two-stage weakly-supervised lung cancer detection and diagnosis network.

Computer-aided lung cancer diagnosis (CAD) system on computed tomography (CT) helps radiologists guide preoperative planning and prognosis assessment. The flexibility and scalability of deep learning methods are limited in lung CAD. In essence, two significant challenges to be solved are (1) Label scarcity due to cost annotations of CT images by experienced domain experts, and (2) Label inconsistency between the observed nodule malignancy and the patients' pathology evaluation. These two issues can be considered weak label problems. We address these issues in this paper by introducing a weakly-supervised lung cancer detection and diagnosis network (WS-LungNet), consisting of a semi-supervised computer-aided detection (Semi-CADe) that can segment 3D pulmonary nodules based on unlabeled data through adversarial learning to reduce label scarcity, as well as a cross-nodule attention computer-aided diagnosis (CNA-CADx) for evaluating malignancy at the patient level by modeling correlations between nodules via cross-attention mechanisms and thereby eliminating label inconsistency. Through extensive evaluations on the LIDC-IDRI public database, we show that our proposed method achieves 82.99% competition performance metric (CPM) on pulmonary nodule detection and 88.63% area under the curve (AUC) on lung cancer diagnosis. Extensive experiments demonstrate the advantage of WS-LungNet on nodule detection and malignancy evaluation tasks. Our promising results demonstrate the benefits and flexibility of the semi-supervised segmentation with adversarial learning and the nodule instance correlation learning with the attention mechanism. The results also suggest that making use of the unlabeled data and taking the relationship among nodules in a case into account are essential for lung cancer detection and diagnosis.

MCA-UNet: multi-scale cross co-attentional U-Net for automatic medical image segmentation.

Medical image segmentation is a challenging task due to the high variation in shape, size and position of infections or lesions in medical images. It is necessary to construct multi-scale representations to capture image contents from different scales. However, it is still challenging for U-Net with a simple skip connection to model the global multi-scale context. To overcome it, we proposed a dense skip-connection with cross co-attention in U-Net to solve the semantic gaps for an accurate automatic medical image segmentation. We name our method MCA-UNet, which enjoys two benefits: (1) it has a strong ability to model the multi-scale features, and (2) it jointly explores the spatial and channel attentions. The experimental results on the COVID-19 and IDRiD datasets suggest that our MCA-UNet produces more precise segmentation performance for the consolidation, ground-glass opacity (GGO), microaneurysms (MA) and hard exudates (EX). The source code of this work will be released via https://github.com/McGregorWwww/MCA-UNet/.

BrainTGL: A dynamic graph representation learning model for brain network analysis.

Modeling the dynamics characteristics in functional brain networks (FBNs) is important for understanding the functional mechanism of the human brain. However, the current works do not fully consider the potential complex spatial and temporal correlations in human brain. To solve this problem, we propose a temporal graph representation learning framework for brain networks (BrainTGL). The framework involves a temporal graph pooling for eliminating the noisy edges as well as data inconsistency, and a dual temporal graph learning for capturing the spatio-temporal features of the temporal graphs. The proposed method has been evaluated in both tasks of brain disease (ASD, MDD and BD) diagnosis/gender classification (classification task) and subtype identification (clustering task) on the four datasets: Human Connectome Project (HCP), Autism Brain Imaging Data Exchange (ABIDE), NMU-MDD and NMU-BD. A large improvement is achieved for the ASD diagnosis. Specifically, our model outperforms the GroupINN and ST-GCN by an average increase of 4.2% and 8.6% on accuracy, respectively, demonstrating its advantages in comparison to the state-of-the-art methods based on functional connectivity features or learned spatio-temporal features. The results demonstrate that learning the spatial-temporal brain network representation for modeling dynamics characteristics in FBNs can improve the model's performance on both disease diagnosis and subtype identification tasks for multiple disorders. Apart from performance, the improvements of computational efficiency and convergence speed reduce training costs.

Exploiting task relationships for Alzheimer's disease cognitive score prediction via multi-task learning.

Alzheimer's disease (AD) is highly prevalent and a significant cause of dementia and death in elderly individuals. Motivated by breakthroughs of multi-task learning (MTL), efforts have been made to extend MTL to improve the Alzheimer's disease cognitive score prediction by exploiting structure correlation. Though important and well-studied, three key aspects are yet to be fully handled in an unified framework: (i) appropriately modeling the inherent task relationship; (ii) fully exploiting the task relatedness by considering the underlying feature structure. (iii) automatically determining the weight of each task. To this end, we present the Bi-Graph guided self-Paced Multi-Task Feature Learning (BGP-MTFL) framework for exploring the relationship among multiple tasks to improve overall learning performance of cognitive score prediction. The framework consists of the two correlation regularization for features and tasks, ℓ2,1 regularization and self-paced learning scheme. Moreover, we design an efficient optimization method to solve the non-smooth objective function of our approach based on the Alternating Direction Method of Multipliers (ADMM) combined with accelerated proximal gradient (APG). The proposed model is comprehensively evaluated on the Alzheimer's disease neuroimaging initiative (ADNI) datasets. Overall, the proposed algorithm achieves an nMSE (normalized Mean Squared Error) of 3.923 and an wR (weighted R-value) of 0.416 for predicting eighteen cognitive scores, respectively. The empirical study demonstrates that the proposed BGP-MTFL model outperforms the state-of-the-art AD prediction approaches and enables identifying more stable biomarkers.

Exploring interpretable graph convolutional networks for autism spectrum disorder diagnosis.

PURPOSE: Finding the biomarkers associated with autism spectrum disorder (ASD) is helpful for understanding the underlying roots of the disorder and can lead to earlier diagnosis and more targeted treatments. In essence, we are faced with two challenges (i) how to learn a node representation and a clean graph structure from original graph data with high dimensionality and (ii) how to jointly model the procedure of node representation learning, structure learning and graph classification. METHODS: We propose FSL-BrainNet, an interpretable graph convolution network (GCN) model for jointly Learning of node Features and clean Structures in brain networks for automatic brain network classification and interpretation. We formulate an end-to-end trainable and interpretable framework for graph classification and biomarkers (salient brain regions and potential subnetworks) identification. RESULTS: The experimental results on the ABIDE dataset show that our proposed methods not only achieve improved prediction performance compared with the state-of-the-art methods, but also find a compact set of highly suggestive biomarkers including relevant brain regions and subnetworks to ASD. CONCLUSION: Through node feature learning and structure learning, our model can simultaneously select important brain regions and identify subnetworks.

Graph Self-Supervised Learning With Application to Brain Networks Analysis.

The less training data and insufficient supervision limit the performance of the deep supervised models for brain disease diagnosis. It is significant to construct a learning framework that can capture more information in limited data and insufficient supervision. To address these issues, we focus on self-supervised learning and aim to generalize the self-supervised learning to the brain networks, which are non-Euclidean graph data. More specifically, we propose an ensemble masked graph self-supervised framework named BrainGSLs, which incorporates 1) a local topological-aware encoder that takes the partially visible nodes as input and learns these latent representations, 2) a node-edge bi-decoder that reconstructs the masked edges by the representations of both the masked and visible nodes, 3) a signal representation learning module for capturing temporal representations from BOLD signals and 4) a classifier used for the classification. We evaluate our model on three real medical clinical applications: diagnosis of Autism Spectrum Disorder (ASD), diagnosis of Bipolar Disorder (BD) and diagnosis of Major Depressive Disorder (MDD). The results suggest that the proposed self-supervised training has led to remarkable improvement and outperforms state-of-the-art methods. Moreover, our method is able to identify the biomarkers associated with the diseases, which is consistent with the previous studies. We also explore the correlation of these three diseases and find the strong association between ASD and BD. To the best of our knowledge, our work is the first attempt of applying the idea of self-supervised learning with masked autoencoder on the brain network analysis.

Modeling global and local label correlation with graph convolutional networks for multi-label chest X-ray image classification.

The diagnosis of chest diseases is a challenging task for assessing thousands of radiology subjects. Their diagnosis decisions heavily rely on the expert radiologists' manual annotations. It is important to develop automated analysis methods for the computer-aided diagnosis of chest diseases on chest radiography. To explore the label relationship and improve the diagnosis performance, we present an end-to-end multi-label learning framework for jointly modeling the global and local label correlation, called GL-MLL that (1) explores the label correlation from a globally static view and a locally adaptive view, (2) considers the imbalanced class distribution, and (3) focuses on capturing label-specific features in image-level representation. We validate the performance of the proposed framework on the CheXpert dataset. The results demonstrate that the proposed GL-MLL outperforms state-of-the-art approaches. The code is available at https://github.com/llt1836/GL-MLL.

Modeling the dynamic brain network representation for autism spectrum disorder diagnosis.

The dynamic functional connectivity analysis provides valuable information for understanding functional brain activity underlying different cognitive processes. Modeling spatio-temporal dynamics in functional brain networks is critical for underlying the functional mechanism of autism spectrum disorder (ASD). In our study, we propose a machine learning approach for the classification of neurological disorders while providing an interpretable framework, which thoroughly captures spatio-temporal features in resting-state functional magnetic resonance imaging (rs-fMRI) data. Specifically, we first transform rs-fMRI time-series into temporal multi-graph using the sliding window technique. A temporal multi-graph clustering is then designed to eliminate the inconsistency of the temporal multi-graph series. Then, a graph structure-aware LSTM (GSA-LSTM) is further proposed to capture the spatio-temporal embedding for temporal graphs. Furthermore, The proposed GSA-LSTM can not only capture discriminative features for prediction but also impute the incomplete graphs for the temporal multi-graph series. Extensive experiments on the autism brain imaging data exchange (ABIDE) dataset demonstrate that the proposed dynamic brain network embedding learning outperforms the state-of-the-art brain network classification models. Furthermore, the obtained clustering results are consistent with the previous neuroimaging-derived evidence of biomarkers for autism spectrum disorder (ASD).