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1.
J Clin Pharm Ther ; 45(4): 628-631, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32369219

RESUMO

WHAT IS KNOWN AND OBJECTIVE: Pazopanib is a tyrosine kinase inhibitor with hyperglycaemia as a known adverse event, but case reports of severe hyperglycaemia are exceptional. We report a case of severe hyperglycaemia following pazopanib administration in a patient with metastatic renal cell carcinoma. CASE SUMMARY: Severe hyperglycaemia developed in a patient one month following initiation of pazopanib therapy. As drug-drug-gene interactions may lead to hyperglycaemia, pharmacogenetic assessment was requested. The obtained findings indicated intermediate function of both OATP1B1 and P-glycoprotein transporters, which may cause prolonged pazopanib bioavailability and increased toxicity. Pazopanib was discontinued and, following patient recovery, was reintroduced at a lower dose. WHAT IS NEW AND CONCLUSION: The pharmacogenetic profiling of the patient on polypharmacy enabled better management of pazopanib therapy.


Assuntos
Carcinoma de Células Renais/tratamento farmacológico , Hiperglicemia/induzido quimicamente , Neoplasias Renais/tratamento farmacológico , Inibidores de Proteínas Quinases/efeitos adversos , Inibidores de Proteínas Quinases/uso terapêutico , Pirimidinas/efeitos adversos , Pirimidinas/uso terapêutico , Sulfonamidas/efeitos adversos , Sulfonamidas/uso terapêutico , Idoso , Carcinoma de Células Renais/genética , Interações Medicamentosas/genética , Humanos , Hiperglicemia/genética , Indazóis , Neoplasias Renais/genética , Masculino
2.
Acta Clin Croat ; 57(3): 449-457, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31168177

RESUMO

- This prospective study in prevalent dialysis patients investigated prognostic properties of low triiodothyronine syndrome, protein-energy wasting and chronic inflammation. Ninety-four prevalent dialysis patients were followed-up for a median of 39 months. Demographic, anthropometric and biochemical parameters were collected at baseline. Univariate and multivariate analysis was done using Cox regression analysis. ROC curve analysis using survival status as a classification variable was performed with the goal of determining optimal cut-off values for numerical variables. In our population, low total triiodothyronine (hazard ratio (HR) 2.19, p=0.038), catheter as vascular access (HR 2.76, p=0.023), higher vintage (HR 1.01, p=0.014) and higher Charlson comorbidity index (HR 1.28, p=0.017) were statistically significantly associated with inferior survival. In our group of steady-state dialysis patients, total triiodothyronine seemed to be the strongest predictor of inferior survival among thyroid hormones. Taking this parameter into account, it was possible to identify patients at an increased risk of death even after adjustment for other prognostically relevant variables. However, after further adjustment for significant risk factors, the impact of C-reactive protein and albumin on survival disappeared due to the overlapping prognostic properties. We concluded that triiodothyronine was an independent prognostic factor in our study group.


Assuntos
Metabolismo Energético , Inflamação , Diálise Renal , Tri-Iodotironina/sangue , Idoso , Proteína C-Reativa/metabolismo , Croácia/epidemiologia , Feminino , Humanos , Inflamação/sangue , Inflamação/diagnóstico , Masculino , Pessoa de Meia-Idade , Prevalência , Prognóstico , Estudos Prospectivos , Curva ROC , Diálise Renal/efeitos adversos , Diálise Renal/métodos , Diálise Renal/mortalidade , Medição de Risco/métodos , Fatores de Risco , Albumina Sérica/análise , Análise de Sobrevida , Hormônios Tireóideos/metabolismo
3.
Int Urol Nephrol ; 55(2): 477-482, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36030358

RESUMO

PURPOSE: The main purpose of this study is to explore characteristics of patients with chronic kidney disease in tuberous sclerosis (TSC) and to underline differences in clinical characteristics between end-stage renal disease (ESRD) patients and patients in earlier stages of chronic kidney disease. METHODS: This multicentric, retrospective study included data for 48 patients from seven South-Eastern European countries (Albania, Bosnia and Herzegovina, Croatia, Greece, Montenegro, Serbia, Slovenia) in the period from February to August 2020. Researchers collected data from local and national nephrological and neurological registries and offered clinical and laboratory results from medical histories in follow-up periods. RESULTS: This study enrolled 48 patients with a median age of 32.3 years (range, 18-46 years), and predominant female gender (60.45%). The percentage of patients with chronic kidney disease (CKD) diagnosis of the total number of patients was 66.90%, with end-stage renal disease development in 39.6%. The most prevalent renal lesions leading to chronic kidney disease were angiomyolipomas (AMLs) in 76.6%, while multiple renal cysts were present in 42.6% of patients. Nephrectomy was performed in 43% of patients, while the mTOR inhibitors were used in 18 patients (37.5%). The majority of patients had cutaneous manifestations of tuberous sclerosis-83.30% had hypomelanotic cutaneous lesions, and 68.80% had angiofibromas. Multiple retinal nodular hamartomas and "confetti" skin lesions were more frequent in end-stage renal disease (ESRD) than in patients with earlier stages of chronic kidney disease (p-0.033 and 0.03, respectively). CONCLUSION: Our study has also shown that retinal hamartomas and "confetti" skin lesions are more frequent in end-stage renal diseases (ESRD) patients than in other chronic kidney disease (CKD) patients. Usage of mTOR inhibitors can also reduce the number of complications and associated with tuberous sclerosis, such as dermatological manifestations and retinal hamartoma, which are more common in the terminal stage of chronic kidney disease.


Assuntos
Angiomiolipoma , Hamartoma , Falência Renal Crônica , Insuficiência Renal Crônica , Dermatopatias , Esclerose Tuberosa , Humanos , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Esclerose Tuberosa/complicações , Esclerose Tuberosa/epidemiologia , Inibidores de MTOR , Estudos Retrospectivos , Hamartoma/complicações , Falência Renal Crônica/etiologia , Falência Renal Crônica/complicações , Angiomiolipoma/complicações , Angiomiolipoma/patologia , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/epidemiologia
4.
BMJ Open ; 6(5): e009757, 2016 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-27188801

RESUMO

OBJECTIVES: Studies have reported that the tunnelled dialysis catheter (TDC) is associated with inferior haemodialysis (HD) patient survival, in comparison with arteriovenous fistula (AVF). Since many cofactors may also affect survival of HD patients, it is unclear whether the greater risk for survival arises from TDC per se, or from associated conditions. Therefore, the aim of this study was to determine, in a multivariate analysis, the long-term outcome of HD patients, with respect to vascular access (VA). DESIGN: Retrospective cohort study. PARTICIPANTS: This retrospective cohort study included all 156 patients with a TDC admitted at University Hospital Merkur, from 2010 to 2012. The control group consisted of 97 patients dialysed via AVF. The groups were matched according to dialysis unit and time of VA placement. The site of choice for the placement of the TDC was the right jugular vein. Kaplan-Meier analysis with log-rank test was used to assess patient survival. Multivariate Cox regression analysis was used to determine independent variables associated with patient survival. PRIMARY OUTCOME MEASURES: Patient survival with respect to VA. RESULTS: The cumulative 1-year survival of patients who were dialysed exclusively via TDC was 86.4% and of those who were dialysed exclusively via AVF, survival was 97.1% (p=0.002). In multivariate Cox regression analysis, male sex and older age were independently negatively associated with the survival of HD patients, while shorter HD vintage before the creation of the observed VA, hypertensive renal disease and glomerulonephritis were positively associated with survival. TDC was an independent risk factor for survival of HD patients (HR 23.0, 95% CI 6.2 to 85.3). CONCLUSION: TDC may be an independent negative risk factor for HD patient survival.


Assuntos
Derivação Arteriovenosa Cirúrgica , Cateterismo Venoso Central , Cateteres de Demora , Falência Renal Crônica/terapia , Diálise Renal , Derivação Arteriovenosa Cirúrgica/mortalidade , Cateterismo Venoso Central/efeitos adversos , Cateteres de Demora/efeitos adversos , Croácia/epidemiologia , Feminino , Humanos , Veias Jugulares , Estimativa de Kaplan-Meier , Falência Renal Crônica/mortalidade , Falência Renal Crônica/fisiopatologia , Masculino , Pessoa de Meia-Idade , Diálise Renal/métodos , Diálise Renal/mortalidade , Estudos Retrospectivos , Análise de Sobrevida
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