Detalhe da pesquisa
1.
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis
; 39(8): 1068-1078, 2018 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29846515
2.
CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement.
Proc Natl Acad Sci U S A
; 111(32): E3260-8, 2014 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25071166
3.
Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators.
FASEB J
; 28(10): 4265-79, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24948597
4.
Analysis of 320 gastroenteropancreatic neuroendocrine tumors identifies TS expression as independent biomarker for survival.
Int J Cancer
; 135(1): 128-37, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24347111
5.
PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer.
Cells
; 13(6)2024 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38534371
6.
PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer.
bioRxiv
; 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38464204
7.
TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background.
Oncogene
; 42(23): 1926-1939, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37106126
8.
Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice.
Cell Death Discov
; 9(1): 1, 2023 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36588105
9.
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival.
JCI Insight
; 8(10)2023 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37097751
10.
Corrigendum: Targeting thymidylate synthase enhances the chemosensitivity of triple-negative breast cancer towards 5-FU-based combinatorial therapy.
Front Oncol
; 13: 1302413, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38162481
11.
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.
Cancer Cell
; 5(4): 341-51, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15093541
12.
BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers.
J Hematol Oncol
; 15(1): 23, 2022 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35260176
13.
Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival.
JCI Insight
; 7(19)2022 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36048542
14.
Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy.
Front Oncol
; 11: 656804, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34336653
15.
MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma.
Oral Oncol
; 98: 147-155, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31606723
16.
Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival.
J Clin Invest
; 129(6): 2279-2292, 2019 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31033480
17.
CDK4/6 inhibition stabilizes disease in patients with p16-null non-small cell lung cancer and is synergistic with mTOR inhibition.
Oncotarget
; 9(100): 37352-37366, 2018 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30647837
18.
NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.
Oncotarget
; 8(34): 57246-57264, 2017 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28915668
19.
Efficient Gene Delivery and Expression in Pancreas and Pancreatic Tumors by Capsid-Optimized AAV8 Vectors.
Hum Gene Ther Methods
; 28(1): 49-59, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28125909
20.
Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine Tumors.
J Natl Cancer Inst
; 107(8)2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25971297