RESUMO
The content of lipid peroxidation products and the metabolism of gangliosides and galactosylceramides in brain tissue were studied in the presence of ischemia and when an agent containing nicotinic acid and cysteine is administered. The above agent was found to have an antioxidative effect that was evident in the lower levels of lipid peroxides and in the normalized qualitative and quantitative content of galactosylceramides and gangliosides.
Assuntos
Antioxidantes/farmacologia , Isquemia Encefálica/tratamento farmacológico , Isquemia Encefálica/metabolismo , Cisteína/farmacologia , Glicolipídeos/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Niacina/farmacologia , Animais , Química Encefálica/efeitos dos fármacos , Masculino , Ratos , Complexo Vitamínico B/farmacologiaRESUMO
Quantitative shifts in the content of interleukine-1, -2 and -6 of the myocardium of mice under the conditions of acoustic stress and delta-sleep inducing peptide action are studied. It has been shown that injection of delta-sleep inducing peptide has no effect on the level of interleukine-1 and -2 in the myocardial tissue, whereas the quantity of interleukine-6 increased. The level of interleukine-1- and -6 in the myocardium were increased and no significant changes were observed in the level of interleukine-2 under the noise action. Interleukine-1- and -2 were not detected in the hypophysis of experimental animals of all groups (intact, under acoustic stress, under delta-sleep inducing peptide application). The level of interleukine-6 in the hypothalamus decreased under conditions of acoustic stress, whereas administration of delta-sleep inducing peptide has no effect on its level. The obtained data are considered in the context of immune modulating properties of delta-sleep inducing peptide.
Assuntos
Peptídeo Indutor do Sono Delta/farmacocinética , Insuficiência Cardíaca/imunologia , Interleucina-1/imunologia , Interleucina-2/imunologia , Interleucina-6/imunologia , Miocárdio/imunologia , Miocárdio/metabolismo , Ruído/efeitos adversos , Fases do Sono/fisiologia , Animais , Peptídeo Indutor do Sono Delta/administração & dosagem , Camundongos , Hipófise/imunologia , Hipófise/metabolismoRESUMO
The study of the content of cerebrosides, gangliosides and their hydrolytic degradation product--sphingosine in the rat brain with experimental edema was carried out. In parallel, the cytokine profile of pro- and anti-inflammatory cytokines in the blood of rats with experimental cerebral edema was studied. The experiments indicated that a decrease of the total fraction of glycolipids and an increase of sphingosine content in the brain of rats with brain swelling were observed. The development of brain edema was accompanied by the increase in proinflammatory and decrease in anti-inflammatory cytokine content.