Detalhe da pesquisa
1.
Pharmacokinetics and ADME Characterization of Intravenous and Oral [14C]-Linerixibat in Healthy Male Volunteers.
Drug Metab Dispos
; 49(12): 1109-1117, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625435
2.
Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs.
Anal Chem
; 92(17): 11851-11859, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32867487
3.
Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space.
Mol Pharm
; 17(2): 488-498, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31834804
4.
Mechanistic Basis of Cabotegravir-Glucuronide Disposition in Humans.
J Pharmacol Exp Ther
; 370(2): 269-277, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31175220
5.
Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways.
Drug Metab Dispos
; 47(8): 890-898, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167838
6.
Hepatobiliary Disposition of Atovaquone: A Case of Mechanistically Unusual Biliary Clearance.
J Pharmacol Exp Ther
; 366(1): 37-45, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653960
7.
Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.
J Pharmacol Exp Ther
; 354(2): 225-9, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26062557
8.
Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.
Drug Metab Dispos
; 43(4): 490-509, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25587128
9.
A first-in-human phase I dose-escalation, pharmacokinetic, and pharmacodynamic evaluation of intravenous LY2090314, a glycogen synthase kinase 3 inhibitor, administered in combination with pemetrexed and carboplatin.
Invest New Drugs
; 33(6): 1187-96, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403509
10.
Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.
Drug Metab Dispos
; 42(11): 1780-4, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25106415
11.
Understanding the transport properties of metabolites: case studies and considerations for drug development.
Drug Metab Dispos
; 42(4): 650-64, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24346835
12.
Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk.
Drug Metab Dispos
; 42(6): 1008-15, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24658455
13.
Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.
Drug Metab Dispos
; 42(1): 182-92, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24194513
14.
Membrane transporters in drug development and as determinants of precision medicine.
Nat Rev Drug Discov
; 23(4): 255-280, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38267543
15.
Metformin sinusoidal efflux from the liver is consistent with negligible biliary excretion and absence of enterohepatic cycling.
Drug Metab Dispos
; 41(11): 1967-71, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24009308
16.
Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
Drug Metab Dispos
; 41(6): 1174-8, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23569176
17.
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Drug Metab Dispos
; 41(4): 714-26, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23305709
18.
Clinical assessment of gepotidacin (GSK2140944) as a victim and perpetrator of drug-drug interactions via CYP3A metabolism and transporters.
Clin Transl Sci
; 16(4): 647-661, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36642822
19.
Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.
Drug Metab Dispos
; 40(6): 1170-7, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22407892
20.
Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
Drug Metab Dispos
; 40(9): 1825-33, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22711747