Detalhe da pesquisa
1.
Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell
; 168(5): 878-889.e29, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235199
2.
Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity.
J Virol
; 95(14): e0237420, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910954
3.
Reflections on the intriguing occurrence of some recently isolated natural products as racemates and scalemic mixtures.
Chirality
; 33(12): 915-930, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34633708
4.
The enduring legacy of Koji Nakanishi's research on bioorganic chemistry and natural products. Part 1: Isolation, structure determination and mode of action.
Chirality
; 32(5): 632-651, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32157754
5.
Biomimetic syntheses of racemic natural products.
Chirality
; 30(2): 157-164, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29139568
6.
Recent Advances in Stereoselective Drug Targeting.
Chirality
; 27(9): 589-97, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26096879
7.
Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers.
Cell Chem Biol
; 31(4): 805-819.e9, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38061356
8.
Synthesis of antioxidants for prevention of age-related macular degeneration.
J Nat Prod
; 76(3): 450-4, 2013 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23346866
9.
Biological stereoselectivity of atropisomeric natural products and drugs.
Chirality
; 25(5): 265-74, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620262
10.
Kinases Controlling Stability of the Oncogenic MYCN Protein.
ACS Med Chem Lett
; 14(12): 1664-1672, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116412
11.
Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia.
Cancer Discov
; 12(11): 2646-2665, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35984649
12.
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.
Nat Commun
; 13(1): 1891, 2022 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35393402
13.
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors.
Nat Commun
; 12(1): 2016, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33795671
14.
Triazines incorporating (R)-3-methylmorpholine are potent inhibitors of the mammalian target of rapamycin (mTOR) with selectivity over PI3Kalpha.
Bioorg Med Chem Lett
; 20(8): 2654-7, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20223664
15.
Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.
Bioorg Med Chem Lett
; 20(1): 375-9, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19897362
16.
Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies.
Bioorg Med Chem Lett
; 20(5): 1535-8, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137930
17.
2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: optimization of human microsomal stability.
Bioorg Med Chem Lett
; 20(8): 2648-53, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20223663
18.
Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Bioorg Med Chem Lett
; 20(2): 640-3, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19963384
19.
Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors.
Bioorg Med Chem Lett
; 20(8): 2644-7, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20227881
20.
Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent.
Bioorg Med Chem Lett
; 20(4): 1440-4, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20089401