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1.
Opt Express ; 27(25): 36405-36413, 2019 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-31873420

RESUMO

A suspended WO3-gate AlGaN/GaN heterostructure photodetector integrated with a micro-heater is micro-fabricated and characterized for ultraviolet photo detection. The transient optical characteristics of the photodetector at different temperatures are studied. The 2DEG-based photodetector shows a recovery (170 s) time under 240 nm illumination at 150 ℃. The measured spectral response of WO3-gate AlGaN/GaN heterostructure shows a high response in deep ultraviolet range. Responsivity at 240 nm wavelength is 4600 A/W at 0.5 V bias. These characteristics support the feasibility of a high accuracy deep UV detector based on the suspended AlGaN/GaN heterostructure integrated with a micro-heater.

2.
Biosens Bioelectron ; 257: 116171, 2024 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-38636317

RESUMO

The COVID-19 pandemic has highlighted the need for rapid and sensitive detection of SARS-CoV-2. Here, we report an ultrasensitive SARS-CoV-2 immunosensor by integration of an AlGaN/GaN high-electron-mobility transistor (HEMT) and anti-SARS-CoV-2 spike protein antibody. The AlGaN/GaN HEMT immunosensor has demonstrated the capability to detect SARS-CoV-2 spike proteins at an impressively low concentration of 10-22 M. The sensor was also applied to pseudoviruses and SARS-CoV-2 ΔN virions that display the Spike proteins with a single virion particle sensitivity. These features validate the potential of AlGaN/GaN HEMT biosensors for point of care tests targeting SARS-CoV-2. This research not only provides the first HEMT biosensing platform for ultrasensitive and label-free detection of SARS-CoV-2.


Assuntos
Técnicas Biossensoriais , COVID-19 , Gálio , SARS-CoV-2 , Glicoproteína da Espícula de Coronavírus , Transistores Eletrônicos , Vírion , SARS-CoV-2/isolamento & purificação , SARS-CoV-2/imunologia , Técnicas Biossensoriais/instrumentação , Técnicas Biossensoriais/métodos , Glicoproteína da Espícula de Coronavírus/imunologia , Glicoproteína da Espícula de Coronavírus/análise , Humanos , COVID-19/diagnóstico , COVID-19/virologia , Gálio/química , Vírion/isolamento & purificação , Vírion/química , Limite de Detecção , Compostos de Alumínio/química , Desenho de Equipamento , Imunoensaio/instrumentação , Imunoensaio/métodos , Anticorpos Imobilizados/química , Anticorpos Antivirais
3.
Nanomaterials (Basel) ; 9(6)2019 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-31174358

RESUMO

A 365-nm UV LED was fabricated based on embedded nanoporous AlGaN distributed Bragg reflectors (DBR) by electrochemical etching. The porous DBR had a reflectance of 93.5% at the central wavelength of 365 nm; this is the highest value of porous AlGaN DBRs below 370 nm which has been reported so far. An innovative two-step etching method with a SiO2 sidewall protection layer (SPL) was proposed to protect the n-AlGaN layer and active region of UV LED from being etched by the electrolyte. The DBR-LED with SPL showed 54.3% improvement of maximal external quantum efficiency (EQE) and 65.7% enhancement of optical power at 100 mA without any degeneration in electrical properties, compared with the un-etched standard LED sample. This work has paved the way for the application of electrically-pumped UV LEDs and VCSELs based on nanoporous AlGaN DBRs.

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