Detalhe da pesquisa
1.
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties.
Invest New Drugs
; 38(1): 29-38, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30887253
2.
Antioxidant Activity and Main Chemical Components of a Novel Fermented Tea.
Molecules
; 24(16)2019 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31408939
3.
Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity.
Molecules
; 24(2)2019 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30642134
4.
Preparation of S14161 and its analogues and the discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a more potent antitumor agent in vitro.
Bioorg Med Chem Lett
; 23(11): 3314-9, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23601711
5.
A branched small molecule-drug conjugate nanomedicine strategy for the targeted HCC chemotherapy.
Eur J Med Chem
; 228: 114037, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34883290
6.
Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.
Bioorg Med Chem Lett
; 21(12): 3730-3, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21555220
7.
In vitro and in vivo antihypertensive and antioxidant activities of fermented roots of Allium hookeri.
Chin Herb Med
; 13(4): 541-548, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36119359
8.
The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo.
Eur J Med Chem
; 187: 111968, 2020 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31865012
9.
SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors.
J Med Chem
; 63(23): 14840-14866, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33201714
10.
Evaluation of WO2017018805: 1,3,4-oxadiazole sulfamide derivatives as selective HDAC6 inhibitors.
Expert Opin Ther Pat
; 28(8): 647-651, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30073889
11.
Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors.
Eur J Med Chem
; 151: 9-17, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29601991
12.
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
J Med Chem
; 59(11): 5341-55, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27172319
13.
Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D3 analogues with aromatic side chains attached at C-17.
Eur J Med Chem
; 85: 569-75, 2014 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25127149
14.
Recent developments of p38α MAP kinase inhibitors as antiinflammatory agents based on the imidazole scaffolds.
Curr Med Chem
; 20(15): 1997-2016, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23317165
15.
Recent developments of small molecule EGFR inhibitors based on the quinazoline core scaffolds.
Anticancer Agents Med Chem
; 12(4): 391-406, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22043991
16.
Syntheses of 2,3-diarylated 2H-benzo[e][1,2]thiazine 1,1-dioxides and their 3,4-dihydro derivatives, and assessment of their inhibitory activity against MCF-7 breast cancer cells.
Med Chem
; 7(6): 561-71, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22313296
17.
A novel substitution at the translation initiator codon (ATG-->ATC) of the lipoprotein lipase gene is mainly responsible for lipoprotein lipase deficiency in a patient with severe hypertriglyceridemia and recurrent pancreatitis.
Biochem Biophys Res Commun
; 341(1): 82-7, 2006 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-16431216