A systemic assessment of the association between tumor necrosis factor alpha 308 G/A polymorphism and risk of cervical cancer.

Tumor necrosis factor alpha (TNF-α) is a multifunctional cytokine which plays an important role in the human immune response against various pathogens, and there may be a relationship between TNF-α 308 G/A polymorphism and cervical cancer risk. We performed a meta-analysis to get a systemic assessment of the association between TNF-α 308 G/A polymorphism and cervical cancer risk. Electronic searches of PubMed, Embase, and Web of Science were performed for all publications on the association between TNF-α 308 G/A polymorphism and cervical cancer risk through October 26, 2012. The pooled odds ratios (ORs) with their 95 % confidence interval (95 % CIs) were calculated to assess the association. Fifteen studies with a total of 3,743 cervical cancer cases and 4,096 controls were finally included into the meta-analysis. Overall, TNF-α 308 G/A polymorphism was significantly associated with increased risk of cervical cancer under three main genetic comparison models (A vs. G, OR 1.20, 95 % CI 1.02-1.42, P=0.03; AA vs. GG, OR 1.31, 95 % CI 1.00-1.72, P=0.048; AA vs. GG/GA, OR 1.30, 95 % CI 1.00-1.71, P=0.05). Subgroup analysis by ethnicity further showed that there was a significant association between TNF-α 308 G/A polymorphism and increased risk of cervical cancer in Asians (AA vs. GG, OR 1.83, 95 % CI 1.05-3.20, P=0.034; AA vs. GG/GA, OR 1.84, 95 % CI 1.05-3.22, P=0.032). The meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with increased risk of cervical cancer, and TNF-α 308 G/A mutant allele A is a risk factor of cervical cancer.

Morphology-controlled synthesis of CoMoO4 nanoarchitectures anchored on carbon cloth for high-efficiency oxygen oxidation reaction.

Novel CoMoO4 nanoarrays with different morphologies are anchored on a carbon cloth via a simple hydrothermal method by adjusting the Co/Mo atom ratio. The in situ growth and tight immobilization of the CoMoO4 nanocomposite on the carbon cloth can facilitate the electrolyte infiltration and electrons transfer rate at the contact interface. Therefore, the free-standing electrode of CoMoO4/carbon cloth with interconnected nanosheets shows superior electrocatalytic activity, and the overpotential of 286 mV is obtained at 15 mA cm-2 in alkaline solution. Moreover, the catalyst also exhibits a small Tafel slope of 67 mV dec-1 as well as good stability. The relationship between the active material morphology, contact interface and the electrocatalytic performance is also discussed. As the carbon cloth is commercially available, this simple but effective structural controlling method demonstrates a new large-scale practical electrode fabrication technique for high performance OER electrodes and large-scale water splitting.