Detalhe da pesquisa
1.
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.
Cell
; 183(2): 490-502.e18, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33002410
2.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Cell
; 160(1-2): 88-104, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25594176
3.
PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Blood
; 141(3): 244-259, 2023 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36206490
4.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
EMBO J
; 39(2): e103637, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31803974
5.
Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase.
Tetrahedron
; 1562024 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38618612
6.
The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors.
J Biol Chem
; 298(7): 102089, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35640720
7.
Nano-DESI Mass Spectrometry Imaging of Proteoforms in Biological Tissues with High Spatial Resolution.
Anal Chem
; 95(12): 5214-5222, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36917636
8.
PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
EMBO Rep
; 22(5): e52141, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33764618
9.
Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
Proc Natl Acad Sci U S A
; 117(34): 20538-20548, 2020 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32788364
10.
Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity.
Molecules
; 28(19)2023 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37836790
11.
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.
Angew Chem Int Ed Engl
; 62(22): e202303818, 2023 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36973833
12.
An Integrated Proteomic Strategy to Identify SHP2 Substrates.
J Proteome Res
; 21(10): 2515-2525, 2022 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36103635
13.
Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2.
J Biol Chem
; 295(18): 6187-6201, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32188694
14.
Functional interrogation and therapeutic targeting of protein tyrosine phosphatases.
Biochem Soc Trans
; 49(4): 1723-1734, 2021 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34431504
15.
Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.
Chem Rev
; 118(3): 1069-1091, 2018 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541680
16.
Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.
Immunol Rev
; 269(1): 212-27, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26683155
17.
Correction to: Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.
Diabetologia
; 67(1): 215, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37861718
18.
First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors.
Bioorg Med Chem Lett
; 29(14): 1836-1841, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31104993
19.
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Genes Dev
; 25(19): 2069-78, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21979919
20.
Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids.
J Am Chem Soc
; 140(50): 17465-17473, 2018 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30461272