1.
Org Biomol Chem
; 19(30): 6588-6592, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34023869
RESUMO
Using visible light as a driving force and molecular oxygen as a green oxidant, we developed bis(oxazoline)-Ni(acac)2 catalyzed asymmetric α-hydroxylation of ß-keto esters under low photosensitizer loading, and the protocol enabled an efficient transformation to provide the desired chiral α-hydroxy-ß-keto esters in high yields (up to 99%) and enantioselectivities (up to 99% ee) at room temperature.