Supramolecular system of podophyllotoxin and hydroxypropyl-ß-cyclodextrin: Characterization, inclusion mode, docking calculation, solubilization, stability and cytotoxic activity.

The inclusion complexation behavior, characterization, and inclusion mode of podophyllotoxin (POD) with hydroxypropyl-ß-cyclodextrin (HPßCD) were investigated in both solution and the solid state by means of XRD, DSC, SEM, 1H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of POD were obviously increased in the inclusion complex with HPßCD. The cytotoxicity of POD/HPßCD inclusion complex against all the human tumor cell lines investigated still remains. This satisfactory water solubility and high thermal stability of the POD/HPßCD complex will be potentially useful for their application as herbal medicines or healthcare products.

Host-guest system of hesperetin and ß-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability.

The inclusion complexation behavior, characterization and binding ability of hesperetin with ß-cyclodextrin and its derivatives were investigated in both the solution and solid state by means of XRD, DSC, SEM, (1)H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and stability of hesperetin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high stability of the hesperetin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.

Preparation and characterization of inclusion complexes of naringenin with ß-cyclodextrin or its derivative.

The inclusion complexation behavior, characterization and binding ability of naringenin with ß-cyclodextrin and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, SEM, (1)H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of naringenin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the naringenin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.