[Correlation between ultrasonographic and celioscopic findings during stimulated cycles in women undergoing fertilization in vitro]. / Korelacija izmedju ultrasonografskog i celioskopskog nalaza u stimulisanim ciklusima zena za fertilizaciju in vitro.

The authors emphasize the importance of ultrasonographic follow-up of the growth and development of the follicle in patients prepared for fertilization in vitro. The study concerned 30 patients in whom an appropriate stimulation was carried out. Correlation between ultrasonographic and coelioscopic findings is analysed. On the basis of the obtained results it was concluded that ultrasonographic diagnosis may be useful in the evaluation of the number, size and volume of a follicle. This method was also appropriate for the evaluation of the follicle maturity and determination of the best time for their puncture. In this was follicles that are in the most favourable time for fertilization in vitro, can be obtained.

[Use of the CO2 laser in the treatment of pathologic changes in the vulva, vagina and uterine cervix]. / Primena CO2-lasera u lecenju patoloskih promena vulve, vagine i grlica materice.

In the period from April 1987 to April 1990, 230 patients with pathological changes of the vulva, vagina and cervix uteri were treated with the CO2-laser. The diagnosis and pretreatment stages of the diseases were confirmed by the cytodiagnostic, colposcopic and histopathological results of the biophysics. In most cases, DNA-hybridization of human papilloma viruses confirmed their virus etiology. Twenty patients had peak condyloma of the vulva and vagina, 34 had benign cervical diseases, 65 were at the premalignant and 111 in the first stages of malignant cervical disease. Vaporizations, conical or cylindrical excisions were performed depending on the nature of disease and its localisation. The average age of operated patients was 30.6 years and the average parity 0.69. Operations were performed using analgesia and in rare cases total anesthesia. After the excision treatment, the tissue was checked histo-pathologically according to the principle of series. The complications were very rare. After operation, postoperative control was performed after 3.9 and 15 months, and later once a year. The results have shown that one treatment was sufficient in 80% of patients for curing vulvar and vaginal disease and 20% patients needed repeat because of the condyloma that relapsed. After the first treatment, benign and premalignant cervical diseases were cured in 100% of cases. In 95.4% operated patients at the first stages of cervical malignant diseases, the excisional treatment was final and in 4.6% needed an additional radical therapy because of a higher stage of lesion found by the conular histo-pathological analysis. There were no relapses relating to the cervix.

Infrequent structural chromosome aberrations in women with primary amenorrhea.

Since the problem of primary amenorrhoea (PA) is very real the authors reviewed a series of 58 women from their own laboratory, citing all known causes of PA and emphasizing that the most interesting cases are those with normal karyotype. Reinvestigation of patients with normal karyotype using the banding methods (G and R) revealed new types of structural aberrations of X chromosome. The importance of structural disturbances and rearrangements of particular segments of X chromosome in the etiology of PA has been discussed.