RESUMO
Naringenin is a naturally occurring flavonoid and due to its broad spectrum of biological activities, including anticancer properties, has attracted scientific attention in recent years. To contribute to these studies, we synthesized some new (±)-naringenin cyclic aminoethyl derivatives, analyzed the cytotoxic and anti-proliferative properties of them via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and mitochondrial apoptosis signaling response and gene expressions belong to caspase-3 depended apoptosis as biomarkers in both healthy and cancer cell lines. Our results suggest that some of our naringenin derivatives are potential anticancer agents with a selective death potential and targeting properties for mitochondrial apoptosis signaling against at least human cervix and breast cancer.
Assuntos
Antineoplásicos Fitogênicos/farmacologia , Apoptose/efeitos dos fármacos , Flavanonas/farmacologia , Antineoplásicos Fitogênicos/síntese química , Antineoplásicos Fitogênicos/química , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Células Cultivadas , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Flavanonas/síntese química , Flavanonas/química , Humanos , Estrutura Molecular , Relação Estrutura-AtividadeRESUMO
The title compound, C7H4F3NO2, 3-tri-fluoro-methyl-1H-pyrrolo-[1,2-c]oxazol-1-one, is the first crystal structure of the pyrrolo-[1,2-c]oxazole ring system: the fused ring system is almost planar (r.m.s. deviation = 0.006â Å). In the crystal, weak C-Hâ¯O and C-Hâ¯F hydrogen bonds link the mol-ecules into [001] chains and π-π stacking inter-actions consolidate the structure.