Adiposity and insulin resistance mediate the inverse association between legume intake and blood pressure: a cross-sectional analysis in secondary cardiovascular prevention.

This study aimed to evaluate the association between legume intake and blood pressure, as well as the mediating role of cardiometabolic risk factors in patients in secondary cardiovascular prevention. Socio-demographic, anthropometric, clinical and food intake data were collected from the baseline of the multicentre study Brazilian Cardioprotective Nutritional Program Trial - BALANCE (RCT: NCT01620398). The relationships between variables were explored through path analysis. In total, 2247 individuals with a median age of 63·0 (45-91) years, 58·8 % (n 1321) male and 96·5 % (n 2168) with diagnosis of hypertension were included. Negative associations were observed between histidine intake and systolic blood pressure (SBP) (standardised coefficient (SC) = -0·057; P = 0·012) and between legume intake and BMI (SC = -0·061; P = 0·006). BMI was positively associated with triglycerides-glucose (TyG) index (SC = 0·173; P < 0·001), SBP (SC = 0·144; P < 0·001) and diastolic blood pressure (DBP) (SC = 0·177; P < 0·001), and TyG index was positively associated with DBP (SC = 0·079; P = 0·001). A negative indirect effect was observed between the intake of legumes, SBP and DBP, mediated by BMI (SC = -0·009; P = 0·011; SC = -0·011; P = 0·010, respectively). In addition, an indirect negative effect was found between the intake of legumes and the DBP, mediated simultaneously by BMI and TyG index (SC = -0·001; P = 0·037). In conclusion, legume intake presented a negative indirect association with blood pressure, mediated by insulin resistance (TyG) and adiposity (BMI) in individuals of secondary care in cardiology.

Personalized Nutrition Using PROCARDIO to Reduce Cardiometabolic Risk in the Academic Community: A Study Protocol with Preliminary Results.

Background: Strategies of promotion, prevention and health care of individuals with cardiometabolic risk are necessary to control cardiovascular diseases.Objective: To describe a study design and present partial results of nutritional counseling in the Cardiovascular Health Care Program (PROCARDIO).Methods: PROCARDIO is a nutritional intervention program for students and workers or dependents of the Brazilian university academic community who are at risk of or have a cardiovascular disease (Brazilian Registry of Clinical Trials n° RBR-5n4y2g). Patients are submitted to nutritional clinical assessments involving anthropometry, biochemical analysis, sociodemographic and clinical, lifestyle and dietary data. Patients are provided with nutritional counseling, dietetic workshops and educational materials. In addition, nutritional following-ups are performed monthly.Results: The sample consisted of 296 patients (171 F/125 M, 27-56 years). The prevalence of individuals with excess body weight, dyslipidemia, diabetes and hypertension in the sample were 74.7% (n = 222), 79.1% (n = 235), 18.2% (n = 54) and 25.3% (n = 75), respectively. After three months of nutritional counseling, PROCARDIO users had decreased body fat, waist circumference, fasting blood glucose, total cholesterol and LDL-C (p < 0.05). Specifically, patients with diabetes exhibited reduced glycated hemoglobin concentrations (p < 0.05); those with dyslipidemia showed a reduction in total cholesterol, LDL-C and LDL/HDL (p < 0.05) concentrations; and those with excess body weight reduced waist circumference, waist-to-hip ratio, body fat, uric acid and total cholesterol/HDL-C ratios (p < 0.05).Conclusion: PROCARDIO patients concluded with a clinical-metabolic improvement regardless of chronic diseases after receiving nutritional counseling, thus highlighting the importance of individual actions and strategies to be based on personalized nutrition for achieving proposed therapeutic targets.