1.
Nano Lett
; 11(2): 541-7, 2011 Feb 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21204579
RESUMO
Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of â¼7 using interferometric cross-polarization microscopy at ultralow excitation powers (â¼1 µW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.