Detalhe da pesquisa
1.
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.
Int J Cancer
; 136(1): 225-33, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24825069
2.
Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.
Mol Pharm
; 12(12): 4259-69, 2015 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26474710
3.
Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).
Pharm Res
; 32(1): 37-46, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24962512
4.
Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
Mol Pharmacol
; 85(3): 520-30, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24334255
5.
Murine Oatp1a/1b uptake transporters control rosuvastatin systemic exposure without affecting its apparent liver exposure.
Mol Pharmacol
; 83(5): 919-29, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23429889
6.
Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.
Mol Pharm
; 9(9): 2497-504, 2012 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22812517
7.
Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate.
Drug Metab Dispos
; 39(8): 1338-44, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21566011
8.
Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo.
Clin Cancer Res
; 15(9): 3084-93, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19383815
9.
Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.
Clin Cancer Res
; 14(24): 8152-60, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19088030
10.
OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
Mol Cancer Ther
; 13(2): 492-503, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24194565
11.
Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice.
Clin Cancer Res
; 19(4): 821-32, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23243220
12.
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.
J Clin Invest
; 122(2): 519-28, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22232210
13.
High impact of Oatp1a/1b transporters on in vivo disposition of the hydrophobic anticancer drug paclitaxel.
Clin Cancer Res
; 17(2): 294-301, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21097690
14.
Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.
Mol Cancer Ther
; 8(12): 3350-9, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19996279
15.
Aggravation of anti-myeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha.
Am J Pathol
; 167(1): 47-58, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15972951
16.
Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity.
Int J Cancer
; 105(1): 20-5, 2003 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12672025