Detalhe da pesquisa
1.
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation.
Br J Clin Pharmacol
; 90(4): 1027-1035, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37990600
2.
Dose escalations in phase I studies: Feasibility of interpreting blinded pharmacodynamic data.
Br J Clin Pharmacol
; 88(12): 5412-5419, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35895751
3.
Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial.
Br J Clin Pharmacol
; 88(3): 1054-1062, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34327732
4.
Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations.
Br J Clin Pharmacol
; 88(5): 2236-2245, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34811788
5.
Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis.
Br J Clin Pharmacol
; 87(3): 1443-1454, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32901947
6.
Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement.
Br J Clin Pharmacol
; 87(12): 4658-4669, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33931884
7.
Comprehensive evaluation of microneedle-based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial.
Br J Clin Pharmacol
; 87(8): 3162-3176, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33403697
8.
Theoretical Performance of Nonlinear Mixed-Effect Models Incorporating Saliva as an Alternative Sampling Matrix for Therapeutic Drug Monitoring in Pediatrics: A Simulation Study.
Ther Drug Monit
; 43(4): 546-554, 2021 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34250966
9.
Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.
Eur J Clin Pharmacol
; 77(8): 1181-1192, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33575848
10.
The power of modelling pulsatile profiles.
J Pharmacokinet Pharmacodyn
; 48(3): 439-444, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33660229
11.
Model informed quantification of the feed-forward stimulation of growth hormone by growth hormone-releasing hormone.
Br J Clin Pharmacol
; 86(8): 1575-1584, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32087619
12.
Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis.
Br J Clin Pharmacol
; 86(1): 175-181, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31658494
13.
Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling.
J Pharmacokinet Pharmacodyn
; 47(3): 229-239, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248329
14.
How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review.
Pituitary
; 21(3): 310-322, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29605877
15.
A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds.
J Pharmacokinet Pharmacodyn
; 44(4): 389-400, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28497294
16.
Item response theory in early phase clinical trials: Utilization of a reference model to analyze the Montgomery-Åsberg Depression Rating Scale.
CPT Pharmacometrics Syst Pharmacol
; 12(10): 1425-1436, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37551774
17.
Correction: Wind et al. Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial. Cancers 2022, 14, 1510.
Cancers (Basel)
; 15(5)2023 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36900424
18.
Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
Clin Pharmacol Ther
; 112(5): 1008-1019, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35762293
19.
Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial.
Cancers (Basel)
; 14(6)2022 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35326659
20.
Accelerating vaccine trial conduct in a pandemic with a hot spot-based inclusion strategy using trial and epidemic simulation.
Clin Transl Sci
; 14(6): 2391-2398, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34260149