Detalhe da pesquisa
1.
Identification of type 2 diabetes loci in 433,540 East Asian individuals.
Nature
; 582(7811): 240-245, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32499647
2.
A Multi-tissue Transcriptome Analysis of Human Metabolites Guides Interpretability of Associations Based on Multi-SNP Models for Gene Expression.
Am J Hum Genet
; 106(2): 188-201, 2020 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978332
3.
The genetic architecture of type 2 diabetes.
Nature
; 536(7614): 41-47, 2016 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27398621
4.
Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling.
Development
; 145(16)2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30042179
5.
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
Am J Hum Genet
; 100(2): 238-256, 2017 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28132686
6.
Colocalization of GWAS and eQTL Signals Detects Target Genes.
Am J Hum Genet
; 99(6): 1245-1260, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27866706
7.
Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.
Diabetologia
; 61(7): 1614-1622, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29675560
8.
Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci.
PLoS Genet
; 11(9): e1005535, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26406328
9.
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
PLoS Genet
; 11(12): e1005694, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26624892
10.
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
PLoS Genet
; 11(7): e1005230, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26132169
11.
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
PLoS Genet
; 10(2): e1004123, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24586183
12.
Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.
Hum Mol Genet
; 23(24): 6432-40, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25015100
13.
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.
Am J Hum Genet
; 92(2): 197-209, 2013 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375658
14.
Human islet function following 20 years of cryogenic biobanking.
Diabetologia
; 58(7): 1503-12, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25930156
15.
PTEN mutations as a cause of constitutive insulin sensitivity and obesity.
N Engl J Med
; 367(11): 1002-11, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22970944
16.
Extent, causes, and consequences of small RNA expression variation in human adipose tissue.
PLoS Genet
; 8(5): e1002704, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22589741
17.
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells.
Wellcome Open Res
; 8: 165, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37736013
18.
Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humans.
J Biol Chem
; 286(21): 19118-26, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454522
19.
SSTR2 is the functionally dominant somatostatin receptor in human pancreatic ß- and α-cells.
Am J Physiol Endocrinol Metab
; 303(9): E1107-16, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22932785
20.
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Cell Stem Cell
; 29(5): 795-809.e11, 2022 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35452598