Thermodynamic temperature assignment to the point of inflection of the melting curve of high-temperature fixed points.

The thermodynamic temperature of the point of inflection of the melting transition of Re-C, Pt-C and Co-C eutectics has been determined to be 2747.84 ± 0.35 K, 2011.43 ± 0.18 K and 1597.39 ± 0.13 K, respectively, and the thermodynamic temperature of the freezing transition of Cu has been determined to be 1357.80 ± 0.08 K, where the ± symbol represents 95% coverage. These results are the best consensus estimates obtained from measurements made using various spectroradiometric primary thermometry techniques by nine different national metrology institutes. The good agreement between the institutes suggests that spectroradiometric thermometry techniques are sufficiently mature (at least in those institutes) to allow the direct realization of thermodynamic temperature above 1234 K (rather than the use of a temperature scale) and that metal-carbon eutectics can be used as high-temperature fixed points for thermodynamic temperature dissemination. The results directly support the developing mise en pratique for the definition of the kelvin to include direct measurement of thermodynamic temperature.

Cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in Thailand.

OBJECTIVE: To assess the health and economic outcomes of various screening and vaccination strategies for cervical cancer prevention. DESIGN: Cost-effectiveness analysis from a societal perspective. SETTING: Thailand. POPULATION: Females aged 9 years and older. METHODS: Using a mathematical model of human papillomavirus (HPV) infection and cervical cancer, calibrated to epidemiological data from Thailand, we estimated the cost-effectiveness of pre-adolescent HPV vaccination, screening [visual inspection with acetic acid (VIA), HPV DNA testing, and cytology] between one and five times per lifetime in adulthood, and combined pre-adolescent vaccination and screening. Vaccine efficacy, coverage, cost, and screening frequency were varied in sensitivity analyses. MAIN OUTCOME MEASURES: Incremental cost-effectiveness ratios, expressed as cost per year of life saved (YLS). RESULTS: Assuming lifelong efficacy and 80% coverage, pre-adolescent HPV vaccination alone was projected to reduce the lifetime risk of cervical cancer by 55%, which was greater than any strategy of screening alone. When cost per vaccinated girl was I$10 (approximately $2 per dose) or less, HPV vaccination alone was cost saving. Pre-adolescent vaccination and HPV DNA testing five times per lifetime, starting at age 35 years, reduced the lifetime cervical cancer risk by 70%, and had a cost-effectiveness ratio less than Thailand's GDP per capita (I$8100), provided the cost per vaccinated girl was I$200 or less. CONCLUSIONS: Low cost pre-adolescent HPV vaccination followed by HPV screening five times per lifetime is an efficient strategy for Thailand. Costs may need to be lower, however, for this strategy to be affordable. If vaccination is not feasible, HPV DNA testing five times per lifetime is efficient.

Sampling period criterion in a scanning-beam technique.

The scanning-beam technique for measuring the response of a detector to an irradiance is analyzed. With this method the irradiance responsivity is determined by integration of the spatial responsivity. Since in practice the integration is approximated by a summation over steps with a finite step size, errors are introduced. It is shown both theoretically and experimentally that the error vanishes when the reciprocal step size lies beyond the diffraction limit. Furthermore, comparison shows that experiment and theory are in good agreement.

Self-dispersive sum-frequency generation at interfaces.

We employ the self-dispersive nature of infrared-visible sum-frequency generation at interfaces to record sumfrequency spectra of molecular monolayers with a spectral resolution of a few inverse centimeters, using IR light with a spectral content of approximately 50 cm(-1).

Transmission reflection anomaly in second-harmonic generation from a monolayer.

We show experimentally that in second-harmonic generation from a monolayer the radiation propagating in transmission and that in reflection can have very different magnitudes. The origin of this difference lies in destructive and constructive interference of the components of the nonlinear polarization that drive the field at the second-harmonic frequency.