Detalhe da pesquisa
1.
Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates.
Antimicrob Agents Chemother
; 68(3): e0129123, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38259087
2.
New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives.
Chembiochem
; 23(21): e202200427, 2022 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36106425
3.
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866868
4.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
5.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
6.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
7.
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites.
ACS Infect Dis
; 9(2): 342-364, 2023 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706233
8.
Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum.
Front Cell Infect Microbiol
; 12: 926460, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35846744
9.
Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination.
Front Cell Infect Microbiol
; 12: 901971, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35755845
10.
In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites.
J Ethnopharmacol
; 297: 115551, 2022 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35850311
11.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Sci Transl Med
; 14(667): eabo7219, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260689
12.
Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites.
ACS Infect Dis
; 7(10): 2904-2916, 2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34569223
13.
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside.
Pharmaceutics
; 13(12)2021 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34959347
14.
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies.
J Med Chem
; 64(8): 5198-5215, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33844521
15.
Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites.
ACS Infect Dis
; 7(7): 1945-1955, 2021 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33673735
16.
Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro.
ACS Med Chem Lett
; 12(8): 1333-1341, 2021 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34413963
17.
New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase.
ACS Infect Dis
; 7(1): 34-46, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33319990
18.
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.
Nat Commun
; 12(1): 269, 2021 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33431834
19.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
20.
Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites.
Sci Rep
; 10(1): 2355, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32047203