Anode Reaction Control for a Single-Compartment Electrochemical CO2 Reduction Reactor with a Surface-Activated Diamond Cathode.

The electrochemical reaction of carbon dioxide (CO2 ) in aqueous electrolyte solutions is attracting increasing attention for sustainable chemical production. Boron-doped diamond (BDD) electrodes have been previously shown to be very effective for the stable electrochemical production of formic acid from CO2 . Typically, the electrochemical production of formic acid by CO2 reduction (CO2 R) reaction is performed with a dual-compartment flow reactor equipped with a membrane separator. The problems caused by the membrane separator, such as scaling-up, complicated operational control and materials costs can be solved using a membrane free single-compartment reactor. Here we demonstrate anode reaction control for a single-compartment CO2 R flow reactor using a surface-activated BDD cathode and achieve a Faradaic efficiency for formic acid production of over 70 %.

Investigation of the electrochemical properties of edoxaban using glassy carbon and boron-doped diamond electrodes and development of an eco-friendly and cost effective voltammetric method for its determination.

In this study, the highly risky drug Edoxaban (EDX), which can threaten life and cause bleeding, was electro analytically evaluated. The electrochemical behavior of EDX was investigated using glassy carbon electrode (GCE) and boron-doped diamond electrode (BDDE). In this study, for the first time, a simple, rapid, sensitive, and selective voltammetric technique was developed by using different electrodes for the electrochemical characterization and detection of EDX. The optimized voltammetric technique showed anodic signals of EDX at +1.09 V and +1.08 V on GCE and BDDE, respectively, in BR (pH 5.0) solution. The developed voltammetric method provided a very good analytical working range for EDX in BR (pH 5.0) solution on GCE and BDDE, covering concentration ranges from 1.84 µM to 12.88 µM and from 3.68 µM to 14.72 µM, respectively. The limits of detection for EDX on GCE and BDDE under these experimental conditions were calculated as 0.24 µM and 0.57 µM, respectively. The developed voltammetric methods on both electrodes were successfully applied to urine and tablet samples. Additionally, the obtained voltammetric results were compared with UV-Vis spectroscopy results.

Electrogenerated chemiluminescence from luminol-labelled microbeads triggered by in situ generation of hydrogen peroxide.

We developed a sensing strategy that mimics the bead-based electrogenerated chemiluminescence immunoassay. However, instead of the most common metal complexes, such as Ru or Ir, the luminophore is luminol. The electrogenerated chemiluminescence of luminol was promoted by in situ electrochemical generation of hydrogen peroxide at a boron-doped diamond electrode. The electrochemical production of hydrogen peroxide was achieved in a carbonate solution by an oxidation reaction, while at the same time, microbeads labelled with luminol were deposited on the electrode surface. For the first time, we proved that was possible to obtain light emission from luminol without its direct oxidation at the electrode. This new emission mechanism is obtained at higher potentials than the usual luminol electrogenerated chemiluminescence at 0.3-0.5 V, in conjunction with hydrogen peroxide production on boron-doped diamond at around 2-2.5 V (vs Ag/AgCl).

Highly Sensitive and Selective Detection of L-Tryptophan by ECL Using Boron-Doped Diamond Electrodes.

L-tryptophan is an amino acid that is essential to the metabolism of humans. Therefore, there is a high interest for its detection in biological fluids including blood, urine, and saliva for medical studies, but also in food products. Towards this goal, we report on a new electrochemiluminescence (ECL) method for L-tryptophan detection involving the in situ production of hydrogen peroxide at the surface of boron-doped diamond (BDD) electrodes. We demonstrate that the ECL response efficiency is directly related to H2O2 production at the electrode surface and propose a mechanism for the ECL emission of L-tryptophan. After optimizing the analytical conditions, we show that the ECL response to L-tryptophan is directly linear with concentration in the range of 0.005 to 1 µM. We achieved a limit of detection of 0.4 nM and limit of quantification of 1.4 nM in phosphate buffer saline (PBS, pH 7.4). Good selectivity against other indolic compounds (serotonin, 3-methylindole, tryptamine, indole) potentially found in biological fluids was observed, thus making this approach highly promising for quantifying L-tryptophan in a broad range of aqueous matrices of interest.

Simultaneous voltammetric determination of 7-methyl-guanine and 5-methyl-cytosine using a cathodically pre-treated boron-doped diamond electrode.

Given the importance of identifying the presence of biomarkers of human diseases in DNA samples, the main objective of this work was to investigate, for the first time, the electro-catalytic oxidation of 7-methyl-guanine (7-mGua) and 5-methyl-cytosine (5-mCyt) on a boron doped diamond electrode pre-treated cathodically (red-BDDE), using differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The anodic peak potentials of 7-mGua and 5-mCyt by DPV were at E = 1.04 V and E = 1.37 V at pH = 4.5, indicating excellent peak separation of approximately 330 mV between species. Using DPV, experimental conditions such as supporting electrolyte, pH and influence of interferents were also investigated to develop a sensitive and selective method for individual and simultaneous quantification of these biomarkers. The analytical curves for the simultaneous quantification of 7-mGua and 5-mCyt in the acid medium (pH = 4.5) were: concentration range of 0.50-5.00 µmol L-1 (r = 0.999), detection limit of 0.27 µmol L-1 for 7-mGua; from 3.00 to 25.00 µmol L-1 (r = 0.998), with a detection limit of 1.69 µmol L-1 for 5-mCyt. A new DP voltammetric method for the simultaneous detection and quantification of biomarkers 7-mGua and 5-mCyt using a red-BDDE is proposed.

Novel Synthesis Pathways for Highly Oxidative Iron Species: Generation, Stability, and Treatment Applications of Ferrate(IV/V/VI).

Difficulties arise related to the economy-of-scale and practicability in applying conventional water treatment technologies to small and remote systems. A promising oxidation technology better suited for these applications is that of electro-oxidation (EO), whereby contaminants are degraded via direct, advanced, and/or electrosynthesized oxidant-mediated reactions. One species of oxidants of particular interest includes ferrates (Fe(VI)/(V)/(IV)), where only recently has their circumneutral synthesis been demonstrated, using high oxygen overpotential (HOP) electrodes, namely boron-doped diamond (BDD). In this study, the generation of ferrates using various HOP electrodes (BDD, NAT/Ni-Sb-SnO2, and AT/Sb-SnO2) was investigated. Ferrate synthesis was pursued in a current density range of 5-15 mA cm-2 and initial Fe3+ concentrations of 10-15 mM. Faradaic efficiencies ranged from 11-23%, depending on operating conditions, with BDD and NAT significantly outperforming AT electrodes. Speciation tests revealed that NAT synthesizes both ferrate(IV/V) and ferrate(VI), while the BDD and AT electrodes synthesized only ferrate(IV/V) species. A number of organic scavenger probes were used to test the relative reactivity, including nitrobenzene, carbamazepine, and fluconazole, whereby ferrate(IV/V) was significantly more oxidative than ferrate(VI). Finally, the ferrate(VI) synthesis mechanism by NAT electrolysis was elucidated, where coproduction of ozone was found to be a key phenomenon for Fe3+ oxidation to ferrate(VI).

Selective Removal of Emerging Organic Contaminants from Water Using Electrogenerated Fe(IV) and Fe(V) under Near-Neutral Conditions.

Fe(IV) and Fe(V) are promising oxidants for the selective removal of emerging organic contaminants (EOCs) from water under near-neutral conditions. The Fe(III)-assisted electrochemical oxidation system with a BDD anode (Fe(III)-EOS-BDD system) has been employed to generate Fe(VI), while the generation and contributions of Fe(IV) and Fe(V) have been largely ignored. Thus, we examined the feasibility and involved mechanisms of the selective degradation of EOCs in the Fe(III)-EOS-BDD system under near-neutral conditions. It was found that Fe(III) application selectively accelerated the electro-oxidation of phenolic and sulfonamide organics and made the oxidation system be resistant to interference from Cl-, HCO3-, and humic acid. Several lines of evidence indicated that EOCs were decomposed via direct electron-transfer process on the BDD anode and by Fe(IV) and Fe(V) but not Fe(VI), besides HO•. Fe(VI) was not generated until the exhaustion of EOCs. Furthermore, the overall contributions of Fe(IV) and Fe(V) to the oxidation of phenolic and sulfonamide organics were over 45%. Our results also revealed that Fe(III) was oxidized primarily by HO• to Fe(IV) and Fe(V) in the Fe(III)-EOS-BDD system. This study advances the understanding of the roles of Fe(IV) and Fe(V) in the Fe(III)-EOS-BDD system and provides an alternative for utilizing Fe(IV) and Fe(V) under near-neutral conditions.

Platinum and palladium nanoparticles on boron-doped diamond for the electrochemical detection of hydrogen peroxide: a comparison study.

Hydrogen peroxide (H2O2) plays a role in many facets - a household item, an important industrial chemical, a biomarker in vivo, and several others. For this reason, its measurement and quantification in a variety of media are important. While spectroscopic detection is primarily used for H2O2, electrochemical methods offer advantages in versatility, cost, and sensitivity. In this work, we investigate a 2-step surface metal nanoparticle (NP) modification for platinum (Pt) and palladium (Pd) on boron-doped diamond (BDD) electrodes for the detection of H2O2. Several parameters such as the metal salt concentration and electrodeposition charge in the 2-step modification were varied to find an optimum. Using cyclic voltammetry (CV), the BDD-PdNP electrode types were found to yield a sharper, more well-resolved H2O2 oxidation peak compared to the BDD-PtNP electrodes. Both metal NP electrode types significantly improved the response compared to the bare BDD electrode; a 150-200× improvement in sensitivity was observed across all modified electrode types. Calibration experiments were completed at both low and high concentration ranges in stagnant and flow-based solutions. The lowest limit of detection (LOD) obtained was 50 nM (5E-08 M) on a BDD-PdNP electrode modified with 1.0 mM PdCl2 to 5.0 mC in the wet chemical seeding and electrodeposition steps. 0.25 mM PdCl2 to 3.23 mC and 0.25 mM HPtCl6- to 3.23 mC also yielded a sufficient response for low-level H2O2, with LODs around 100 nM (1E-07 M). Overall, this work exemplifies the wide applicability of BDD and achieves sub-µM H2O2 LODs with a non-enzymatic electrode material.

Boron-doped diamond nanosheet volume-enriched screen-printed carbon electrodes: a platform for electroanalytical and impedimetric biosensor applications.

This paper focuses on the development of a novel electrode based on boron-doped diamond nanosheet full-volume-enriched screen-printed carbon electrodes (BDDPE) for use as an impedimetric biosensor. Impedimetric biosensors offer high sensitivity and selectivity for virus detection, but their use as point-of-care devices is limited by the complexity of nanomaterials' architecture and the receptor immobilisation procedures. The study presents a two-step modification process involving the electroreduction of diazonium salt at the BDDPE and the immobilisation of antibodies using zero-length cross-linkers for a selective impedimetric biosensor of Haemophilus influenzae (Hi). The incorporation of diamond nanosheets into BDDPE leads to enhanced charge transfer and electrochemical behaviour, demonstrating greatly improved electrochemically active surface area compared with unmodified screen-printed electrodes (by 44% and 10% on average for [Ru(NH3)6]Cl2 and K3[Fe(CN)6], respectively). The presented sensing system shows high specificity towards protein D in Hi bacteria, as confirmed by negative controls against potential interference from other pathogens, with an estimated tolerance limit for interference under 12%. The Hi limit of detection by electrochemical impedance spectroscopy was 1 CFU/mL (measured at - 0.13 V vs BDDPE pseudo-reference), which was achieved in under 10 min, including 5 min sample incubation in the presence of the analyte.

Comparison of Chemical and Electrochemical Approaches to Abacavir Oxidative Stability Testing.

A novel electrochemical approach using two different electrode materials, platinum and boron-doped diamond (BDD), was employed to study the oxidative stability of the drug abacavir. Abacavir samples were subjected to oxidation and subsequently analysed using chromatography with mass detection. The type and amount of degradation products were evaluated, and results were compared with traditional chemical oxidation using 3% hydrogen peroxide. The effect of pH on the rate of degradation and the formation of degradation products were also investigated. In general, both approaches led to the same two degradation products, identified using mass spectrometry, and characterised by 319.20 and m/z 247.19. Similar results were obtained on a large-surface platinum electrode at a potential of +1.15 V and a BDD disc electrode at +4.0 V. Degradation of 20% of abacavir, the rate required for pharmaceutical stability studies, took only a few minutes compared to hours required for oxidation with hydrogen peroxide. Measurements further showed that electrochemical oxidation in ammonium acetate on both types of electrodes is strongly pHdependent. The fastest oxidation was achieved at pH 9. The pH also affects the composition of the products, which are formed in different proportions depending on the pH of the electrolyte.

An Electrochemical Sensor of Theophylline on a Boron-Doped Diamond Electrode Modified with Nickel Nanoparticles.

Theophylline is a drug with a narrow therapeutic range. Electrochemical sensors are a potentially effective method for detecting theophylline concentration to prevent toxicity. In this work, a simple modification of a boron-doped diamond electrode using nickel nanoparticles was successfully performed for a theophylline electrochemical sensor. The modified electrode was characterized using a scanning electron microscope and X-ray photoelectron spectroscopy. Square wave voltammetry and cyclic voltammetry methods were used to study the electrochemical behavior of theophylline. The modified nickel nanoparticles on the boron-doped diamond electrode exhibited an electrochemically active surface area of 0.0081 cm2, which is larger than the unmodified boron-doped diamond's area of 0.0011 cm2. This modified electrode demonstrated a low limit of detection of 2.79 µM within the linear concentration range from 30 to 100 µM. Moreover, the modified boron-doped diamond electrode also showed selective properties against D-glucose, ammonium sulfate, and urea. In the real sample analysis using artificial urine, the boron-doped diamond electrode with nickel nanoparticle modifications achieved a %recovery of 105.10%, with a good precision of less than 5%. The results of this work indicate that the developed method using nickel nanoparticles on a boron-doped diamond electrode is promising for the determination of theophylline.

An Interference-Free Voltammetric Method for the Detection of Sulfur Dioxide in Wine Based on a Boron-Doped Diamond Electrode and Reaction Electrochemistry.

This paper describes a new, simple, and highly selective analytical technique for the detection of sulfur dioxide in wine, as a real sample with a relatively complicated matrix. The detection of the above analyte was based on the electrogeneration of iodine from iodide on a boron-doped diamond electrode, without modifications, in the presence of 0.1 mol dm-3 HClO4 as a supporting electrolyte. The electrogenerated iodine reacted with sulfur dioxide, forming iodide ions and sulfuric acid (i.e., a Bunsen reaction). The product of this reaction, the iodide ion, diffused back to the surface of the boron-doped diamond electrode and oxidized itself again. This chemical redox cycling enhanced the voltammetric response of the boron-doped diamond electrode. The selectivity of the determination was assured using NaOH and formaldehyde during sample preparation, and a blank was also measured and taken into account. The detection limit was estimated to be 10-6-10-7 mol dm-3. However, the content of sulfur dioxide in wine is significantly higher, which can lead to more accurate and reliable results.

Effect of Carbon Layer Thickness on the Electrocatalytic Oxidation of Glucose in a Ni/BDD Composite Electrode.

High-performance non-enzymatic glucose sensor composite electrodes were prepared by loading Ni onto a boron-doped diamond (BDD) film surface through a thermal catalytic etching method. A carbon precipitate with a desired thickness could be formed on the Ni/BDD composite electrode surface by tuning the processing conditions. A systematic study regarding the influence of the precipitated carbon layer thickness on the electrocatalytic oxidation of glucose was conducted. While an oxygen plasma was used to etch the precipitated carbon, Ni/BDD-based composite electrodes with the precipitated carbon layers of different thicknesses could be obtained by controlling the oxygen plasma power. These Ni/BDD electrodes were characterized by SEM microscopies, Raman and XPS spectroscopies, and electrochemical tests. The results showed that the carbon layer thickness exerted a significant impact on the resulting electrocatalytic performance. The electrode etched under 200 W power exhibited the best performance, followed by the untreated electrode and the electrode etched under 400 W power with the worst performance. Specifically, the electrode etched under 200 W was demonstrated to possess the highest sensitivity of 1443.75 µA cm-2 mM-1 and the lowest detection limit of 0.5 µM.

Electrochemical Epoxidation Catalyzed by Manganese Salen Complex and Carbonate with Boron-Doped Diamond Electrode.

Epoxides are essential precursors for epoxy resins and other chemical products. In this study, we investigated whether electrochemically oxidizing carbonate ions could produce percarbonate to promote an epoxidation reaction in the presence of appropriate metal catalysts, although Tanaka and co-workers had already completed a separate study in which the electrochemical oxidation of chloride ions was used to produce hypochlorite ions for electrochemical epoxidation. We found that epoxides could be obtained from styrene derivatives in the presence of metal complexes, including manganese(III) and oxidovanadium(IV) porphyrin complexes and manganese salen complexes, using a boron-doped diamond as the anode. After considering various complexes as potential catalysts, we found that manganese salen complexes showed better performance in terms of epoxide yield. Furthermore, the substituent effect of the manganese salen complex was also investigated, and it was found that the highest epoxide yields were obtained when Jacobsen's catalyst was used. Although there is still room for improving the yields, this study has shown that the in situ electrochemical generation of percarbonate ions is a promising method for the electrochemical epoxidation of alkenes.

Photoelectrocatalytic degradation of diclofenac with a boron-doped diamond electrode modified with titanium dioxide as a photoanode.

The electrophoretic deposition of titanium dioxide (TiO2) nanoparticles (Degussa P25) onto a boron-doped diamond (BDD) substrate was carried out to produce a photoanode (TiO2/BDD) to apply in the degradation and mineralization of sodium diclofenac (DCF-Na) in an aqueous medium using photoelectrocatalysis (PEC). This study was divided into three stages: i) photoanode production through electrophoretic deposition using three suspensions (1.25%, 2.5%, 5.0% w/v) of TiO2 nanoparticles, applying 4.8 V for 15 and 20 s; ii) characterization of the TiO2/BDD photoanode using scanning electron microscopy and cyclic voltammetry response with the [Fe(CN)6]3-/4- redox system; iii) degradation of DCF-Na (25 mg L-1) through electrochemical oxidation (EO) on BDD and PEC on TiO2/BDD under dark and UVC-light conditions. The degradation of DCF-Na was evaluated using high-performance liquid chromatography and UV-Vis spectroscopy, and its mineralization measured using total organic carbon and chemical oxygen demand. The results showed that after 2 h, DCF-Na degradation and mineralization reached 98.5% and 80.1%, respectively, through PEC on the TiO2/BDD photoanode at 2.2 mA cm-2 under UVC illumination, while through EO on BDD applying 4.4 mA cm-2, degradation and mineralization reached 85.6% and 76.1%, respectively. This difference occurred because of the optimal electrophoretic formation of a TiO2 film with a 9.17 µm thickness on the BDD (2.5% w/v TiO2, time 15 s, 4.8 V), which improved the electrocatalysis and oxidative capacity of the TiO2/BDD photoanode. Additionally, PEC showed a lower specific energy consumption (1.55 kWh m-3). Thus, the use of nanostructured TiO2 films deposited on BDD is an innovative photoanode alternative for the photoelectrocatalytic degradation of DCF-Na, which substantially improves the degradation capacity of bare BDD.

Effect of electrolyte composition on electrochemical oxidation: Active sulfate formation, benzotriazole degradation, and chlorinated by-products distribution.

Electrochemical oxidation is an effective technique for treating persistent organic pollutants, which are hardly removed in conventional wastewater treatment plants. Sulfate and chloride salts commonly used and present in natural wastewater influence the electrochemical degradation process. In this study, the effect of electrolyte composition on the active sulfate species (SO4●⁻ and S2O82⁻) formation, benzotriazole degradation-a model organic compound, and chlorinated by-products distribution have been investigated while using a boron-doped diamond (BDD) anode. Different Na2SO4:NaNO3 and Na2SO4:NaCl ratios with constant conductivity of 10 mS/cm were used in the experiments and applied anode potential was kept constant at 4.3 V vs. Ag/AgCl. The electrogenerated SO4●⁻ and S2O82⁻ formation were faster in 10:1 and 2:1 Na2SO4:NaNO3 ratios than in the 1:0 ratio. The ●OH-mediated SO4●⁻ production has prevailed in 10:1 and 2:1 ratios. However, ●OH-mediated SO4●⁻ production has hindered the 1:0 ratio due to excess chemisorption of SO42⁻ on the BDD anode. Similarly, the faster benzotriazole degradation, mineralization, and lowest energy consumption were achieved in the 10:1 Na2SO4:NaNO3 and Na2SO4:NaCl ratio. Besides, chlorinated organic by-product concentration (AOX) was lower in the 10:1 Na2SO4:NaCl ratio but increased with the increasing chloride ratio in the electrolyte. LC-MS analysis shows that several chlorinated organic transformation products were produced in 0:1 to 2:1 ratio, which was not found in the 10:1 Na2SO4:NaCl ratio. A comparatively higher amount of ClO4⁻ was formed in the 10:1 ratio than in 2:1 to 0:1 ratio. This ClO4⁻ formation train evidence the effective ●OH generation in a sulfate-enriched condition because the ClO4⁻ formation is positively correlated to ●OH concentration. Overall results show that sulfate-enriched electrolyte compositions are beneficial for electrochemical oxidation of biorecalcitrant organic pollutants.

Impact of electrolyte solution on electrochemical oxidation treatment of Escherichia coli K-12 by boron-doped diamond electrodes.

We studied the disinfection efficacy of boron-doped electrodes on Escherichia coli-contaminated water-based solutions in three different electrolytes, physiological solution (NaCl), phosphate buffer (PB), and phosphate buffer saline (PBS). The effect of the electrochemical oxidation treatment on the bacteria viability was studied by drop and spread plate cultivation methods, and supported by optical density measurements. We have found that bacterial suspensions in NaCl and PBS underwent a total inactivation of all viable bacteria within 10 min of the electrochemical treatment. By contrast, experiments performed in the PB showed a relatively minor decrease of viability by two orders of magnitude after 2 h of the treatment, which is almost comparable with the untreated control. The enhanced bacterial inactivation was assigned to reactive chlorine species, capable of penetrating the bacterial cytoplasmic membrane and killing bacteria from within.

pH Measurement at Elevated Temperature with Vessel Gate and Oxygen-Terminated Diamond Solution Gate Field Effect Transistors.

Diamond has many appealing properties, including biocompatibility, ease of surface modification, and chemical-physical stability. In this study, the temperature dependence of the pH-sensitivity of a oxygen-terminated boron-doped diamond solution gate FET (C-O BDD SGFET) is reported. The C-O BDD SGFET operated in an electrolyte solution at 95 °C. At 80 °C, the pH sensitivity of C-O BDD SGFET dropped to 4.27 mV/pH. As a result, we succeeded in developing a highly sensitive pH sensing system at -54.6 mV/pH at 80 °C by combining it with a highly pH sensitive stainless-steel vessel.

Nitrogen and organic load removal from anaerobically digested leachate using a hybrid electro-oxidation and electro-coagulation process.

This study evaluated the performance of an integrated electrochemical process, which simultaneously utilizes electro-oxidation (EO) and electro-coagulation (EC) methods while removing organic and nitrogen loads from high-strength leachate obtained from anaerobic digesters. A bipolar arrangement of the aluminum electrode, sandwiched between a monopolar boron-doped diamond anode and stainless-steel cathode, integrates EC and EO into a single reactor. This arrangement demonstrated an enhancement of 33%, 27%, and 24% in removal capacity for ammonia nitrogen (AN), total Kjeldahl nitrogen (TKN), and total nitrogen, respectively, when compared to just EO at 0.8 A current intensity after 24 h. Increasing the current intensity from 0.4 A to 1.0 A enhanced the organic nitrogen and AN removal. Chemical oxygen demand (COD) exhibited initial faster removal kinetics with higher current intensities and eventually reached 95%-98% removal for intensities of 0.6 A or higher. Additional removal for AN, TKN were also observed with increasing current intensity. Lowering the pH further expedited the COD removal kinetics. Reducing and maintaining the pH at 4, 6, and 8 by dosing of hydrochloric acid (HCl) resulted in the 100% removal of AN and TKN from the integrated system in 6, 8, and 20 h, respectively. Accelerated removal of COD and the enhanced removal of AN and TKN through pH control could be linked to the formation of active chlorine species in bulk solution. The integrated system offered lower energy consumption than EO due to oxidation on the additional anodic surface of the bipolar electrode, as well as the adsorption-precipitation of contaminants in aluminum flocs.

Electrochemical Characterization and Voltammetric Determination of Methylisothiazolinone on a Boron-Doped Diamond Electrode.

The electrochemical properties of methylisothiazolinone (MIT), the most widely used preservative, were investigated by cyclic (CV) and differential pulse voltammetry (DPV) to develop a new method for its determination. To our knowledge, this is the first demonstration of a voltammetric procedure for the determination of MIT on a boron-doped diamond electrode (BDDE) in a citrate-phosphate buffer (C-PB) environment. The anodic oxidation process of methylisothiazolinone, which is the basis of this method, proved to be diffusion-controlled and proceeded with an irreversible two-electron exchange. The radical cations, as unstable primary products, were converted in subsequent chemical reactions to sulfoxides and sulfones, and finally to more stable final products. Performed determinations were based on the DPV technique. A linear calibration curve was obtained in the concentration range from 0.7 to 18.7 mg L-1, with a correlation coefficient of 0.9999. The proposed procedure was accurate and precise, allowing the detection of MIT at a concentration level of 0.24 mg L-1. It successfully demonstrated its suitability for the determination of methylisothiazolinone in household products without the need for any separation steps. The proposed method can serve as an alternative to the prevailing chromatographic determinations of MIT in real samples.